2,5-Bis-benzyloxy-benzoic acid
- CAS No.
- 67127-91-7
- Chemical Name:
- 2,5-Bis-benzyloxy-benzoic acid
- Synonyms
- 2,5-Bis-benzyloxy-benzoic acid;Benzoic acid, 2,5-bis(phenylmethoxy)-
- CBNumber:
- CB1703915
- Molecular Formula:
- C21H18O4
- Molecular Weight:
- 334.37
- MDL Number:
- MFCD00156981
- MOL File:
- 67127-91-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
2,5-Bis-benzyloxy-benzoic acid price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 37445 | 2,5-BIS-BENZYLOXY-BENZOIC ACID 96% | 67127-91-7 | 1G | $58 | 2026-04-30 | Buy |
| aablocks | AA005QRD | 2,5-Bis(Benzyloxy)Benzoic Acid 98% | 67127-91-7 | 250mg | $19 | 2026-05-28 | Buy |
| aablocks | AA005QRD | 2,5-Bis(Benzyloxy)Benzoic Acid 98% | 67127-91-7 | 1g | $50 | 2026-05-28 | Buy |
| aablocks | AA005QRD | 2,5-Bis(Benzyloxy)Benzoic Acid 98% | 67127-91-7 | 5g | $174 | 2026-05-28 | Buy |
| aablocks | AA005QRD | 2,5-Bis(Benzyloxy)Benzoic Acid 98% | 67127-91-7 | 10g | $305 | 2026-05-28 | Buy |
2,5-Bis-benzyloxy-benzoic acid Chemical Properties, Uses, Production
Synthesis
78283-37-1
67127-91-7
General procedure for the synthesis of 2,5-bis-benzyloxybenzoic acid from the compound (CAS: 78283-37-1): 1.0 g (2.4 mmol) of the ester 25 and 0.19 g (4.7 mmol) of sodium hydroxide were dissolved in 15 mL of a solvent mixture of methanol, dioxane, and water (1:1:1, v/v), and stirred at reflux for 14 hours. After completion of the reaction, it was cooled to 25 °C and most of the organic solvent was removed by rotary evaporator. The residue was diluted with water, acidified with 1N HCl to pH < 7 and subsequently extracted twice with ethyl acetate (50 mL). The organic phases were combined, washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate, and concentrated. The crude product was purified by column chromatography using hexane and ethyl acetate (1:1, v/v) as eluents to afford 0.72 g (91% yield) of the target compound 13.1H NMR (δ, ppm): 11.06 (s, 1H), 7.81 (d, J = 3.1 Hz, 1H), 7.43-7.32 (m, 10H), 7.17 (dd, J = 9.0, 3.1 Hz, 1H), 7.07 (d, J = 9.0 Hz, 1H), 5.26 (s, 2H), 5.08 (s, 2H); 13C NMR (δ, ppm): 165.3, 153.9, 151.9, 136.6, 134.6, 129.4, 129.4, 128.8, 128.4, 128.2, 127.8, 123.0, 119.0, 117.8, 115.1, 73.2, 70.9.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 353 - 356
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981, p. 2570 - 2576
[3] Journal of Organic Chemistry, 2004, vol. 69, # 10, p. 3530 - 3537
2,5-Bis-benzyloxy-benzoic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
2,5-Bis-benzyloxy-benzoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
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| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| ShangHai KenEn Chemical Technology Co., Ltd. | 13120367189;18621755571 | mychess007@163.com | China | 1994 | 55 |
| Wuhan Chemwish Technology Co.， Ltd | 027-67849912 | sales@chemwish.com | China | 9144 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58851090 13913916777 | sales01@aikonchem.com | China | 15947 | 58 |
| Weichang Yuanhe Biotech R&D Co.,Ltd. | 0314-7886310 18830416512 | weichangyuanhe@163.com | China | 203 | 58 |
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