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4-Nitro-3-phenyl-L-alanine

4-Nitro-3-phenyl-L-alanine structure

CAS No.: 949-99-5

Chemical Name:: 4-Nitro-3-phenyl-L-alanine

Synonyms: (S)-2-AMINO-3-(4-NITROPHENYL)PROPANOIC ACID;L-4-NITROPHENYLALANINE;4-NITRO-L-PHENYLALANINE;4-NO2-Phe;L-4-NITROPHE;L-Phe(4-NO2);(P-NO2)PHE-OH;L-4-NO2-Phe-OH;L-Phe(4-NO2)-OH;H-PHE(4-NO2)-OH

CBNumber:: CB7382549

Molecular Formula:: C9H10N2O4

Molecular Weight:: 210.19

MDL Number:: MFCD00051221

MOL File:: 949-99-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-29 08:43:58

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4-Nitro-3-phenyl-L-alanine Properties

Melting point	236-239°C (dec.)
Boiling point	414.1±35.0 °C(Predicted)
Density	1.408±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Powder
pka	2.12±0.10(Predicted)
Appearance	Off-white to light brown Solid
InChI	InChI=1S/C9H10N2O4/c10-8(9(12)13)5-6-1-3-7(4-2-6)11(14)15/h1-4,8H,5,10H2,(H,12,13)/t8-/m0/s1
InChIKey	GTVVZTAFGPQSPC-QMMMGPOBSA-N
SMILES	C(O)(=O)[C@H](CC1=CC=C([N+]([O-])=O)C=C1)N
CAS DataBase Reference	949-99-5(CAS DataBase Reference)
FDA UNII	45BD1566VA

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Danger

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c

Hazard Codes

Xn,C,F

Risk Statements

36/37/38-22-34-11

Safety Statements

26-36/37/39-22-45-16

RIDADR

2811

RTECS

AY7400000

Hazard Note

Harmful

HS Code

29224999

NFPA 704

	1
2		0

4-Nitro-3-phenyl-L-alanine price More Price(75)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	R267678	2-AMINO-3-(4-NITRO-PHENYL)-PROPIONIC ACID Aldrich^CPR	949-99-5	1 unit	$32.7	2026-04-30	Buy
Sigma-Aldrich	R267678	2-AMINO-3-(4-NITRO-PHENYL)-PROPIONIC ACID AldrichCPR	949-99-5	50MG	$29.8	2024-03-01	Buy
TCI Chemical	N0682	4-Nitro-L-phenylalanine Hydrate >98.0%(HPLC)(T)	949-99-5	1g	$22	2026-04-30	Buy
TCI Chemical	N0682	4-Nitro-L-phenylalanine Hydrate >98.0%(HPLC)(T)	949-99-5	5g	$37	2026-04-30	Buy
Usbiological	285587	4-Nitro-L-phenylalanine Asreported	949-99-5	10g	$347	2026-06-03	Buy

Product number	Packaging	Price	Buy
R267678	1 unit	$32.7	Buy
R267678	50MG	$29.8	Buy
N0682	1g	$22	Buy
N0682	5g	$37	Buy
285587	10g	$347	Buy

4-Nitro-3-phenyl-L-alanine Chemical Properties, Uses, Production

Chemical Properties

white to light yellow crystal powde

Uses

4-Nitro-L-phenylalanine is used in the studies on the rational manipulation of protein structures for the expansion of the genetic code with non natural amino acids into protein via in vitro translation.

Synthesis

63-91-2

949-99-5

General steps: 1. dissolve L-phenylalanine (16.5 g, 100 mmol) in 85% sulfuric acid (50 ml). 2. under stirring conditions, add slowly and dropwise a pre-prepared and cooled to room temperature acid mixture of concentrated nitric acid and concentrated sulfuric acid (1.4:1.1 by volume). 3. Stir the reaction mixture continuously for 5 hours at room temperature. 4. The pH of the reaction solution was adjusted to 2-3 using 40% sodium hydroxide solution, at which time a large amount of precipitate was formed. 5. Collect the precipitate by filtration and wash with deionized water until the filtrate is neutral. 6. 6. Dry the precipitate under reduced pressure to obtain 4-nitro-L-phenylalanine (20 g, yield 95.2%).

References

[1] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 8, p. 3118 - 3125
[2] Patent: US2009/247470, 2009, A1. Location in patent: Page/Page column 12
[3] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 18, p. 5352 - 5360
[4] Russian Journal of Organic Chemistry, 2016, vol. 52, # 11, p. 1681 - 1685
[5] Zh. Org. Khim., 2016, vol. 52, # 11, p. 1686 - 1690,5

4-Nitro-3-phenyl-L-alanine Preparation Products And Raw materials

Raw materials

Phenylalanine, N-acetyl-4-nitro- L-Phenylalanine Sulfuric acid Nitric acid Sodium hydroxide

Preparation Products

Fmoc-4-nitro-L-phenylalanine BOC-L-4-Nitrophe

4-Nitro-3-phenyl-L-alanine Suppliers

Global Suppliers ( 393)

Supplier	Tel	Email	Country	ProdList	Advantage
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.	21-33585366 13311639313	sales@shyrchem.com	China	807	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Shanghai HC Biotech Co., Ltd	021-20227858	sale@hcbiotech.com.cn	China	1173	55
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56

Supplier	Advantage
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.	55
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Shanghai HC Biotech Co., Ltd	55
INTATRADE GmbH	66
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
ShangHai DEMO Chemical Co.,Ltd	57
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56

View Latest Price from 4-Nitro-3-phenyl-L-alanine manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-29	4-Nitro-3-phenyl-L-alanine 949-99-5	1kg	98%	1000kgs	Shaanxi Dideu New Materials Co. Ltd
2025-04-04	4-Nitro-3-phenyl-L-alanine 949-99-5	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2022-02-22	4-Nitro-L-phenylalanine 949-99-5	1KG	97.9%	100 tons	Honest Joy Holdings Limited

4-Nitro-3-phenyl-L-alanine
949-99-5
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

4-Nitro-3-phenyl-L-alanine
949-99-5
98%
Henan Aochuang Chemical Co.,Ltd.

4-Nitro-L-phenylalanine
949-99-5
$0.00
97.9%
Honest Joy Holdings Limited

4-Nitro-3-phenyl-L-alanine Spectrum

4-Nitro-3-phenyl-L-alanine(949-99-5)MS 4-Nitro-3-phenyl-L-alanine(949-99-5)¹HNMR 4-Nitro-3-phenyl-L-alanine(949-99-5)IR1 4-Nitro-3-phenyl-L-alanine(949-99-5)IR2

949-99-5 (4-Nitro-3-phenyl-L-alanine) Related Search:

4-Nitrophenyl chloroformate L-Alanine 4-Nitrobenzoic acid Propionic acid 4-Nitrophenylacetic acid

D-Phenylalanine 4-Nitrobenzaldehyde DL-Phenylalanine p-Nitrophenylacetonitrile Phenprobamate

Phenylhydrazine 4-Nitrobenzonitrile 4-Fluoronitrobenzene N-(tert-Butoxycarbonyl)-L-phenylalanine L-Phenylalanine

Glycine Phenyl valerate 4-Nitrophenylacetylene

1of4

H-L-Phe(4-NH2)-OH*1.5H2O 4-NITRO-L-PHENYLALALANINE HYDRATE 4-Nitro-L-Phenylalanine, p-Nitro-L-Phenylalanine (S)-α-Amino-4-nitrobenzenepropionic acid 4-Nitro-L-phenylalanine ,98% 4-Nitro-3-phenyl-L-a DL-4-NO2-Phe-OH 4-Nitro-L-Phenylalanine 4-L-Nitrophenylalanine 4 - nitro-L-phenylal Melphalan Impurity 1 4-Nitro-3-phenyl-L-alanine 2-Amino-3-(4-nitrophenyl)propanoic acid 4-Nitro-L-phenylalanine.H2O 4-Nitro-L-phenylalanine Hydrate L-Phe(4-NO2)-OH P-NITRO-PHENYLALANINE P-NITRO-L-PHENYLALANINE P-NITRO-2-PHENYLALANINE (P-NO2)PHE-OH (S)-4-NITROPHENYLALANINE (S)-4-NITROPHENYLALANINE HYDRATE RARECHEM BK PT 0073 4-nitro-l-phenylalanin l-3-(p-nitrophenyl)alanine l-beta-nitrophenylalanine l-p-nitrophenylalanine L-4-NITROPHE H-PHE(4-NO2)-OH H-P-NITRO-PHE-OH 4-NITRO-3-PHENYL-L-ALANINE P-NITRO-L-PHENYLALANINE MONOHYDRATE 4-NITRO-L-PHENYLALNINE 4-Nitro-L-Phenylalanino 3-(4-Nitrophenyl)-L-alaninehydrate L-4-Nitrophenylalaninehydrate (2S)-2-amino-3-(4-nitrophenyl)propanoic acid 3-(4-Nitrophenyl)-L-alanine 2-AMINO-3-(4-NITROPHENYL)PROPANOIC ACID L-4-NO2-Phe-OH 4-NITRO- PHE-OH HYDRATE 98.5% 4-Nitro-L-phenylalanine(H-Phe(4-NO2)-OH) 4-NO2-Phe 4-Nitro-L-phenylalanineHydrate> L-Phenylalanine, 4-nitro- (2S)-2-amino-3-(4-nitrophenyl)propanoicaci 4-Nitro-3-phenyl-L-alanine USP/EP/BP 4-Iodine-L-phenylalanine L-Phe(4-NO2) H-L-Phe(4-NO2)-OH 4-Nitro-L< (S)-4-Nitrophenylalanine, 98% 4-nitro-L-phenylalanine (anhydrous) L-4-Nitro-Phenylalanine.H2O (S)-2-AMINO-3-(4-NITROPHENYL)PROPANOIC ACID 4-NITRO-L-PHENYLALANINE L-4-NITROPHENYLALANINE 949-99-5 945-99-5 207951-86-4