2-Cyano-3-fluoropyridine
- CAS No.
- 97509-75-6
- Chemical Name:
- 2-Cyano-3-fluoropyridine
- Synonyms
- 3-FLUOROPICOLINONITRILE;3-Fluoropyridine-2-carbonitrile;3-FLUORO-2-PYRIDINECARBONITRILE;Rebamipide salt;2-CYANO-3-FLUOROPYRIDINE;2-Cyano-3-fluoropyridine >2-Cyano-3-fluoropyridine, 97+%;2-Pyridinecarbonitrile,3-fluoro-;3-Fluoropyridine-2-carbonitrile97%;3-Fluoropyridine-2-carbonitrile 97%
- CBNumber:
- CB1765018
- Molecular Formula:
- C6H3FN2
- Molecular Weight:
- 122.1
- MDL Number:
- MFCD06797501
- MOL File:
- 97509-75-6.mol
- MSDS File:
- SDS
| Melting point | 27-30°C |
|---|---|
| Boiling point | 120-125 °C(Press: 17 Torr) |
| Density | 1.24±0.1 g/cm3(Predicted) |
| Flash point | 104 °C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Sparingly), DMSO (Slightly) |
| form | Solid |
| pka | -2.74±0.10(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C6H3FN2/c7-5-2-1-3-9-6(5)4-8/h1-3H |
| InChIKey | VZFPSCNTFBJZHB-UHFFFAOYSA-N |
| SMILES | C1(C#N)=NC=CC=C1F |
| CAS DataBase Reference | 97509-75-6(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302+H312+H332-H315-H318-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | T,Xi,Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38-41-37/38 | |||||||||
| Safety Statements | 26-36/37/39-23 | |||||||||
| RIDADR | 3276 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Toxic | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2-Cyano-3-fluoropyridine price More Price(73)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 697109 | 3-Fluoro-2-pyridinecarbonitrile 96% | 97509-75-6 | 5g | $115 | 2026-04-30 | Buy |
| Sigma-Aldrich | 697109 | 3-Fluoro-2-pyridinecarbonitrile 96% | 97509-75-6 | 1g | $28.5 | 2023-06-20 | Buy |
| TCI Chemical | C2655 | 2-Cyano-3-fluoropyridine >98.0%(GC) | 97509-75-6 | 1g | $19 | 2026-04-30 | Buy |
| TCI Chemical | C2655 | 2-Cyano-3-fluoropyridine >98.0%(GC) | 97509-75-6 | 5g | $57 | 2026-04-30 | Buy |
| Usbiological | 270502 | 2-Cyano-3-fluoropyridine Asreported | 97509-75-6 | 5g | $389 | 2026-06-03 | Buy |
2-Cyano-3-fluoropyridine Chemical Properties, Uses, Production
Chemical Properties
Light yellow Cryst
Uses
2-Cyano-3-fluoropyridine is an organic intermediate that can be prepared from 3-fluoropyridine in three steps.
Synthesis
695-37-4
7677-24-9
97509-75-6
Using 3-fluoropyridine-N-oxide (Intermediate A, 2.85 g, 25.2 mmol) and trimethylcyanosilane (10.0 mL, 75.6 mmol) as raw materials, Intermediate A was dissolved in dichloromethane (25 ml) at room temperature, followed by addition of trimethylcyanosilane. The reaction mixture was heated to reflux for 10 hours. After completion of the reaction, it was cooled to room temperature and the reaction was quenched by the addition of saturated aqueous sodium bicarbonate solution (30 mL). The reaction mixture was extracted with dichloromethane (3 x 150 mL), the organic phases were combined and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give a light brown oily crude product (4.60 g). The crude product was purified by rapid column chromatography on silica gel, the eluent was hexane solution of 30% ethyl acetate to give a light brown oil, which solidified to light brown solid product B (2.48 g, 84% yield) after standing. The product was analyzed by HPLC with a retention time of 1.03 min.
References
[1] Patent: WO2003/90912, 2003, A1. Location in patent: Page/Page column 65
[2] Chemical and Pharmaceutical Bulletin, 1985, vol. 33, # 2, p. 565 - 571
[3] Patent: WO2006/12374, 2006, A1. Location in patent: Page/Page column 213
[4] Patent: US2004/77605, 2004, A1
[5] Patent: US2003/232842, 2003, A1. Location in patent: Page 7-8
2-Cyano-3-fluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Bailong Pharmaceutical Co., Ltd. | 15562090112 | 3131095341@qq.com | China | 146 | 58 |
| Jinan LuoHe PharmaTech Co., Ltd. | 86-0531-68658065 15726150375 | 1071018499@qq.com | China | 525 | 58 |
| Fuxin Custchem Fine Chemical Co., Ltd. | 0418-5113999 18740177324 | sales@custchem.com.cn | China | 448 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
View Latest Price from 2-Cyano-3-fluoropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-16 | 2-Cyano-3-fluoropyridine
97509-75-6
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | 2-Cyano-3-fluoropyridine
97509-75-6
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 2-Cyano-3-fluoropyridine
97509-75-6
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 2-Cyano-3-fluoropyridine
97509-75-6
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2-Cyano-3-fluoropyridine
97509-75-6
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 2-Cyano-3-fluoropyridine
97509-75-6
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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