5-(Trifluoromethyl)nicotinonitrile
- CAS No.
- 951624-83-2
- Chemical Name:
- 5-(Trifluoromethyl)nicotinonitrile
- Synonyms
- 5-(Trifluoromethyl)nicotinonitrile;3-Cyano-5-(trifluoromethyl)-pyridine;5-(Trifluoromethyl)nicotinonitrile, 95+%;5-(Trifluoromethyl)-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 5-(trifluoroMethyl)-;5-(Trifluoromethyl)pyridine-3-carbonitrile ;5-(Trifluoromethyl)pyridine-3-carbonitrile, CAS 951624-83-2
- CBNumber:
- CB1815108
- Molecular Formula:
- C7H3F3N2
- Molecular Weight:
- 172.11
- MDL Number:
- MFCD07368841
- MOL File:
- 951624-83-2.mol
- MSDS File:
- SDS
| Melting point | 46-47°C |
|---|---|
| Boiling point | 204.4±35.0 °C(Predicted) |
| Density | 1.37±0.1 g/cm3(Predicted) |
| Flash point | 82℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| form | solid |
| pka | -0+-.0.20(Predicted) |
| Appearance | White to off-white Solid |
| InChI | 1S/C7H3F3N2/c8-7(9,10)6-1-5(2-11)3-12-4-6/h1,3-4H |
| InChIKey | HAWFNLPVIMFXGB-UHFFFAOYSA-N |
| SMILES | FC(F)(F)c1cncc(c1)C#N |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H315-H318-H335 |
| Precautionary statements | P280-P301+P310+P330-P302+P352-P305+P351+P338+P310 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | Xi,T |
| Risk Statements | 25-37/38-41 |
| Safety Statements | 7/9-22-24/25-26-36/37/39-45-51 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
5-(Trifluoromethyl)nicotinonitrile price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 708151 | 5-(Trifluoromethyl)pyridine-3-carbonitrile 95% | 951624-83-2 | 250mg | $29.2 | 2026-04-30 | Buy |
| Apolloscientific | PC520548 | 5-(Trifluoromethyl)nicotinonitrile ≥95% | 951624-83-2 | 250mg | $102 | 2026-06-04 | Buy |
| Apolloscientific | PC520548 | 5-(Trifluoromethyl)nicotinonitrile ≥95% | 951624-83-2 | 1g | $204 | 2026-06-04 | Buy |
| Apolloscientific | PC520548 | 5-(Trifluoromethyl)nicotinonitrile ≥95% | 951624-83-2 | 5g | $816 | 2026-06-04 | Buy |
| Activate Scientific | AS42758 | 5-(Trifluoromethyl)nicotinonitrile 98% | 951624-83-2 | 1g | $347 | 2026-06-04 | Buy |
5-(Trifluoromethyl)nicotinonitrile Chemical Properties, Uses, Production
Synthesis
557-21-1
436799-33-6
951624-83-2
Example 1.1.27: Synthesis of (5-(trifluoromethyl)pyridin-3-yl)methanamine: 3-bromo-5-(trifluoromethyl)pyridine (1.0 g, 4.42 mmol, 1 eq.) was dissolved in 20 mL of anhydrous DMF. The solution was degassed by argon bubbling. Zinc cyanide (Zn(CN)2, 0.312 g, 2.65 mmol, 0.6 eq.) and tetrakis(triphenylphosphine)palladium (Pd(PPh3)4) were subsequently added and the resulting reaction mixture was heated to 80 °C and stirred overnight. Upon completion of the reaction, the mixture was cooled to room temperature and diluted with ether (Et2O). The organic and aqueous layers were separated by adding 28% ammonia (NH4OH) with continuous stirring. The organic layer was sequentially washed three times with water, once with brine and dried with anhydrous sodium sulfate (Na2SO4). After filtration to remove inorganic salts, the filtrate was concentrated under reduced pressure. Finally, it was purified by silica gel fast column chromatography to obtain 5-(trifluoromethyl)nicotinonitrile (0.310 g, 1.95 mmol, 44% yield).
References
[1] Patent: WO2009/42694, 2009, A1. Location in patent: Page/Page column 84
5-(Trifluoromethyl)nicotinonitrile Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai JingSi Biological Technology Co., Ltd | 18221840760 | 2990760589@qq.com | China | 241 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
View Latest Price from 5-(Trifluoromethyl)nicotinonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-10 | 3-Pyridinecarbonitrile,5-(trifluoromethyl)-
951624-83-2
|
$9.80 | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- 3-Pyridinecarbonitrile,5-(trifluoromethyl)-
951624-83-2
- $9.80
- ≥98%
- Career Henan Chemical Co
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