5-Trifluoromethyl-pyridin-3-ylamine
- CAS No.
- 112110-07-3
- Chemical Name:
- 5-Trifluoromethyl-pyridin-3-ylamine
- Synonyms
- 5-(TrifluoroMethyl)pyridin-3-aMine;5-(Trifluoromethyl)-3-pyridinamine;3-Amino-5-trifluoromethyl-pyridine;3-Pyridinamine,5-(trifluoromethyl);5-(TrifluorMethyl)-3-aMinopyridine;5-Trifluoromethyl-pyridin-3-ylamine;5-Trifluoromethyl-pyridin-3-ylamine ISO 9001：2015 REACH
- CBNumber:
- CB41560086
- Molecular Formula:
- C6H5F3N2
- Molecular Weight:
- 162.11
- MDL Number:
- MFCD00128900
- MOL File:
- 112110-07-3.mol
- MSDS File:
- SDS
| Melting point | 40-41.5 °C |
|---|---|
| Boiling point | 105.5-106 °C(Press: 11 Torr) |
| Density | 1.368 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 3.74±0.20(Predicted) |
| Appearance | Colorless to light yellow <40°C Solid,>41.5°C Liquid |
| InChI | InChI=1S/C6H5F3N2/c7-6(8,9)4-1-5(10)3-11-2-4/h1-3H,10H2 |
| InChIKey | NJFRBMFEAGFNDC-UHFFFAOYSA-N |
| SMILES | C1=NC=C(C(F)(F)F)C=C1N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| RIDADR | UN2811 |
| HS Code | 2933399990 |
5-Trifluoromethyl-pyridin-3-ylamine price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 51723 | 5-(TRIFLUOROMETHYL)PYRIDIN-3-AMINE 96% | 112110-07-3 | 0.25G | $11 | 2026-04-30 | Buy |
| AstaTech | 51723 | 5-(TRIFLUOROMETHYL)PYRIDIN-3-AMINE 96% | 112110-07-3 | 1G | $15 | 2026-04-30 | Buy |
| AstaTech | 51723 | 5-(TRIFLUOROMETHYL)PYRIDIN-3-AMINE 96% | 112110-07-3 | 5G | $59 | 2026-04-30 | Buy |
| Apolloscientific | PC301200 | 3-Amino-5-(trifluoromethyl)pyridine 97% | 112110-07-3 | 1g | $28 | 2026-06-04 | Buy |
| Apolloscientific | PC301200 | 3-Amino-5-(trifluoromethyl)pyridine 97% | 112110-07-3 | 5g | $69 | 2026-06-04 | Buy |
5-Trifluoromethyl-pyridin-3-ylamine Chemical Properties, Uses, Production
Synthesis
72587-15-6
112110-07-3
Step Ia: 5-(Trifluoromethyl)-2-chloro-3-nitropyridine (0.850 g, 3.75 mmol) was dissolved in methanol (17 mL), and palladium carbon (800 mg, 10% wetted, 0.375 mmol) was added. The reaction mixture was hydrogenated for 16 h at 60 psi hydrogen pressure and 20 °C. The progress of the reaction was monitored by LCMS to confirm that the starting material (M + H 213/215, 3:1) and hydroxylamine intermediate were completely consumed and a mixture of partially reduced product (M + H 163; UVmax 214, 258, 332 nm) and completely reduced product (M + H 169; no UV absorption) was detected. After completion of the reaction, the reaction mixture was filtered and the filter cake was washed well with methanol. The filtrate was concentrated in vacuum to give 0.74 g of product in the form of HCl salt. Subsequently, the product was purified by preparative HPLC/MS using a 30 mm × 100 mm C18 column; the mobile phase was 20% acetonitrile-water (containing 0.1% NH4OH), with an initial hold of 1 min and a gradient up to 40% over 6 min; the flow rate was 60 mL/min; the detector was set at m/z 163; and the product retention time was 4.4 min. Fractions containing the pure product were collected, combined and concentrated to give 52 mg of the product as an oil in 8% yield.1H NMR (CDCl3) δ 8.26 (s, 1H); 8.24 (d, 1H); 7.15 (t, 1H); 4.00 (s, 2H).
References
[1] Patent: WO2008/79965, 2008, A1. Location in patent: Page/Page column 72-73
[2] Patent: US2006/4018, 2006, A1. Location in patent: Page/Page column 14; 35-36
5-Trifluoromethyl-pyridin-3-ylamine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang Jiaguo Biotechnology Co., Ltd | 0576-057687838881 13968486607 | shxc7755@163.com | China | 157 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Shangchem Co., Ltd. | +86-21-68182121 | China | 881 | 52 | |
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 28-83379370 13880556291 | tcy@tcypharm.com | China | 509 | 57 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
View Latest Price from 5-Trifluoromethyl-pyridin-3-ylamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 5-Trifluoromethyl-pyridin-3-ylamine
112110-07-3
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2025-04-04 | 5-Trifluoromethyl-pyridin-3-ylamine
112110-07-3
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
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 |
2020-01-03 | 5-Trifluoromethyl-pyridin-3-ylamine
112110-07-3
|
$6.60 | 1KG | 97%-99% | 1kg -1000kg | Career Henan Chemical Co |
-
- 5-Trifluoromethyl-pyridin-3-ylamine
112110-07-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 5-Trifluoromethyl-pyridin-3-ylamine
112110-07-3
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 5-Trifluoromethyl-pyridin-3-ylamine
112110-07-3
- $6.60
- 97%-99%
- Career Henan Chemical Co
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