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Chloroform-d

Chloroform-d Structure
Chloroform-d structure
CAS No.
865-49-6
Chemical Name:
Chloroform-d
Synonyms
CDCL3;deuterated chloroform;CHLOROFORM-D1;DEUTEROCHLOROFORM;Deuteriochloroform;Deuterotrichloromethane;Trichloro(2H)methane;Methane-d, trichloro-;Chloroform-d, 99.8 atom % D, anhydrous;Chloroform-d, 99.8% Isotopic, contains 1% TMS
CBNumber:
CB2103569
Molecular Formula:
CCl3D
Molecular Weight:
120.38
MDL Number:
MFCD00000827
MOL File:
865-49-6.mol
MSDS File:
SDS
Last updated:2026-06-23 10:29:20
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Chloroform-d Properties

Melting point -63,5°C
Boiling point 61-62°C
Density d = 1,5
vapor pressure 211 hPa (20 °C)
refractive index n20/D 1.444(lit.)
Flash point 62°C
storage temp. Store at +2°C to +8°C.
solubility Miscible with organic solvents, ethyl acetate and acetone.
form Liquid
color White to beige
Specific Gravity 1.505
Solvent Residual Peak 1H NMR：7.26 ppm (s)
13C NMR：77.16±0.03 ppm (t)
Water Solubility 4.6g/L
Sensitive Moisture Sensitive
BRN 1697633
Exposure limits ACGIH: TWA 10 ppm
OSHA: Ceiling 50 ppm(240 mg/m3)
NIOSH: IDLH 500 ppm; STEL 2 ppm(9.78 mg/m3)
Stability Stable. Incompatible with strong bases, alkali metals, aluminium, magnesium, strong oxidizing agents.
InChI 1S/CHCl3/c2-1(3)4/h1H/i1D
InChIKey HEDRZPFGACZZDS-MICDWDOJSA-N
SMILES [2H]C(Cl)(Cl)Cl
LogP 1.5-1.6 at 20-23℃ and pH9
Surface tension 72.3mN/m at 998.5mg/L and 20℃
CAS DataBase Reference 865-49-6(CAS DataBase Reference)
FDA UNII P1NW4885VT
EPA Substance Registry System Chloroform-d (865-49-6)
UNSPSC Code 12142201
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Health Hazard (GHS08)
GHS06,GHS08
Signal word  Danger
Hazard statements  H302-H315-H319-H331-H336-H351-H361d-H372
Precautionary statements  P201-P301+P312-P302+P352-P304+P340+P311-P305+P351+P338-P308+P313
target organs Central nervous system, Liver,Kidney
PPE Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,T
Risk Statements  22-38-40-48/20/22-48/20-36/38-20/22-63
Safety Statements  36/37
RIDADR  UN 1888 6.1/PG 3
WGK Germany  2
HazardClass  6.1
PackingGroup  III
HS Code  28459000
Hazard Classifications Acute Tox. 3 Inhalation
Acute Tox. 4 Oral
Carc. 2
Eye Irrit. 2
Repr. 2
Skin Irrit. 2
STOT RE 1 Oral
STOT SE 3
Toxicity LD50 orally in Rabbit: 695 mg/kg LD50 dermal Rabbit > 3980 mg/kg
REACH Registrations Active
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
3 1

Chloroform-d price More Price(149)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 151823 Chloroform-d 99.8 atom % D 865-49-6 10x0.6ml $38.3 2026-04-30 Buy
Sigma-Aldrich 151823 Chloroform-d 99.8 atom % D 865-49-6 10x0.75ml $44.4 2026-04-30 Buy
Sigma-Aldrich 1.03420 Chloroform-D1 deuteration degree min. 99.8% for NMR spectroscopy (stabilized with silver) MagniSolv? 865-49-6 100mL $120 2026-04-30 Buy
Sigma-Aldrich 1.03420 Chloroform-D1 deuteration degree min. 99.8% for NMR spectroscopy (stabilized with silver) MagniSolv? 865-49-6 500mL $498 2026-04-30 Buy
Sigma-Aldrich 1.03296 Chloroform-D1 0.03 vol.% TMS, deuteration degree min. 99.8% for NMR spectroscopy (stabilized with silver) MagniSolv? 865-49-6 100mL $115 2026-04-30 Buy
Product number Packaging Price Buy
151823 10x0.6ml $38.3 Buy
151823 10x0.75ml $44.4 Buy
1.03420 100mL $120 Buy
1.03420 500mL $498 Buy
1.03296 100mL $115 Buy

Chloroform-d Chemical Properties,Uses,Production

Water peak

The position of the water peak in different deuterated reagents is not the same. The water peak of heavy water is about 4.67 ppm. There is a trend that the more water the low field.
Chloroform-D is less soluble with water and the water content is low, so its water peak near 1.59 ppm. Deuterated acetone is about 2.8 ppm and the deuterated dimethylsulfoxide has a water peak of about 3.4 ppm. If water is added to deuterated acetone, the water peak will gradually move to a low field and eventually stop at about 4.7 ppm.

Application

Chloroform-d has been employed as solvent in a 1H NMR (Proton Nuclear Magnetic Resonance) spectroscopic study. It has been employed as solvent during the 31PNMR (Phosphorus-31 nuclear magnetic resonance) spectral investigation of triphenyl phosphate and tris(2-chloroethyl) phosphate. It has also been used as the deuterated solvent in the 1H NMR spectral studies of 2-(4-bromobenzyl)-3-hydroxypropanoic acid and 3-hydroxy-2-(4-methoxybenzyl)propanoic acid. It has also been used as the deuterated solvent for the 1HNMR spectral studies of  3,3′-dihydroxy-4,4′-diamino-biphenyl (HAB) and 2,2′-bis-(3,4-dicarboxy-phenyl) hexafluoropropane dianhydride (6FDA) polyimide.Chloroform-d has been employed as solvent in a 1H NMR (Proton Nuclear Magnetic Resonance) spectroscopic study. It has been employed as solvent during the 31PNMR (Phosphorus-31 nuclear magnetic resonance) spectral investigation of triphenyl phosphate and tris(2-chloroethyl) phosphate. It has also been used as the deuterated solvent in the 1H NMR spectral studies of 2-(4-bromobenzyl)-3-hydroxypropanoic acid and 3-hydroxy-2-(4-methoxybenzyl)propanoic acid. It has also been used as the deuterated solvent for the 1HNMR spectral studies of  3,3′-dihydroxy-4,4′-diamino-biphenyl (HAB) and 2,2′-bis-(3,4-dicarboxy-phenyl) hexafluoropropane dianhydride (6FDA) polyimide.

Description

Deuterated chloroform (CDCl3), also known as chloroform-d, is an excellent everyday solvent choice for scientists who demand exceptional results. Commonly used as a solvent in proton NMR (1H NMR) spectroscopy, chloroform-d can dissolve a vast array of compounds with ease due to its weak polarity. It is often used in combination with methanol-d as a cosolvent. Plus, its low boiling point makes it relatively easy to recover a sample post-NMR analysis or during organic syntheses.

Chemical Properties

colourless liquid

Uses

Labelled Chloroform, generally in trimethylsilane solution, used in NMR spectroscopy as a solvent. Unlabelled chloroform has been used an an anaesthetic due to its action on the central nervous system .

Uses

Chloroform-d is widely used in the organic solvent for the NMR analysis.

Uses

Chloroform-d may be used in the synthesis of dichlorofluoromethane-d (DCFM).

Definition

ChEBI: Deuterated chloroform is a deuterated compound that is an isotopologue of chloroform in which the hydrogen atom is replaced with deuterium. Commonly used as a solvent in proton NMR spectroscopy. It has a role as a non-polar solvent, a NMR solvent and a NMR chemical shift reference compound. It is a deuterated compound and a member of chloromethanes.

Preparation

On a large-scale, chloroform-d (CDCl3) is synthesized by treatment of a hypochlorite salt with deuterated acetone/ethanol or the reaction between chloral and sodium deuteroxide (NaOD). The NaOD is prepared from the reaction of deuterium oxide (D2O) and sodium metal, which liberate deuterium gas from the reaction mixture; therefore, this reaction has drawbacks, including the danger of explosion of the deuterium gas and high risk for use of metal sodium on larger scales. In order to avoid the above drawbacks, the convenient reaction of sodium peroxide and D2O was used to prepare NaOD.
Production of Chloroform-d

General Description

Chloroform-d (Deuterochloroform, CDCl3), deuterated chloroform, is a 100% isotopically enriched NMR (Nuclear Magnetic Resonance) solvent. It is widely employed in high resolution NMR studies due to its high chemical and isotopic purity. Quantitaive infrared spectral investigations of carbon-deuterium stretching bands of chloroform-d in various organic solvents have been reported. Raman difference spectroscopic studies of mixtures of chloroform-d and liquid chloroform have been conducted to evaluate frequency shifts in the in the ν1 and ν2 bands of CHCl3 and CDCl3.

References

[1] LIA ZAHARANI  Mohd R B J, NADER GHAFFARI KHALIGH*   Cost and Energy Saving Process for the Laboratory-Scale Production of Chloroform-d[J]. Organic Process Research & Development, 2022, 26 11: 3126-3129. DOI:10.1021/acs.oprd.2c00260.
[2] MEI-CHUN WU, HUA YANG*   Photoredox-Catalyzed C–H Trideuteromethylation of Quinoxalin-2(1H)-ones with CDCl3 as the “CD3” source[J]. Organic Letters, 2022, 24 35: 6412-6416. DOI:10.1021/acs.orglett.2c02439.

Chloroform-d Preparation Products And Raw materials

Raw materials

Sodium deuteroxide Deuterium oxide Hexachloroacetone Calcium oxide

Preparation Products

4-Amino-3-formylpyridine

Chloroform-d Suppliers

Global( 276)Suppliers
Supplier Tel Email Country ProdList Advantage
Ningbo cuiying chemical technology co. LTD 0574-88162057 18957423231 2317559463@qq.com China 323 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Wuhan eastop Technology Co., ltd.6 18086015167 17702779303 service@isotopechina.com China 234 58
Qingdao Tenglong microwave technology co., LTD. 0532-83818797 17669478191 sc@tlwb.com.cn China 3933 58
CHINA ISOTOPE CO., LIMITED 02151600108 13062666369 info@isotopechem.com China 4721 58
Central China Special Gas (CCSG) Co., Ltd 0734-8755555 15674722888 lyq@ccsg.cn China 405 58
Shanghai Maclean Biochemical Technology Co., LTD 021-50706066 15221275939 shenlinxing@macklin.cn China 29676 58
Shanghai Chemilab Biotechnology CO.,Ltd 18116465878 kmlb@kaimilaibo.com China 2414 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 021-4009004166/18616739031 18616739031 3007523370@qq.com China 40000 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Supplier Advantage
Ningbo cuiying chemical technology co. LTD 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Wuhan eastop Technology Co., ltd.6 58
Qingdao Tenglong microwave technology co., LTD. 58
CHINA ISOTOPE CO., LIMITED 58
Central China Special Gas (CCSG) Co., Ltd 58
Shanghai Maclean Biochemical Technology Co., LTD 58
Shanghai Chemilab Biotechnology CO.,Ltd 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 58
J & K SCIENTIFIC LTD. 76

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View Lastest Price from Chloroform-d manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Chloroform-d pictures 2026-09-02 Chloroform-d
865-49-6
 $1.00-100.00 1KG 99% Henan Fengda Chemical Co., Ltd
Chloroform-D pictures 2026-08-08 Chloroform-D
865-49-6
 200kg 99% Hangzhou ICH Biofarm Co., Ltd
Chloroform-d pictures 2026-06-30 Chloroform-d
865-49-6
 1KG 98 10000KGS Shaanxi Dideu New Materials Co. Ltd
  • Chloroform-d pictures
  • Chloroform-d
    865-49-6
  • $1.00-100.00
  • 99%
  • Henan Fengda Chemical Co., Ltd

Chloroform-d Spectrum

Chloroform-d(865-49-6)MSChloroform-d(865-49-6)1HNMRChloroform-d(865-49-6)13CNMRChloroform-d(865-49-6)IR1Chloroform-d(865-49-6)Raman

865-49-6(Chloroform-d)Related Search:

Ethyl (2,4,6-trimethylbenzoyl) phenylphosphinate Chlorobutanol ACETONE-D6 DICHLOROMETHANE D TRIS(DIBENZYLIDENEACETONE)DIPALLADIUM(0) CHLOROFORM ADDUCT 98+%
5α-Cholestane 100 MG/ML CHOLESTERYL ACETATE IN CHLOROFORM-D Dichloromethane Chloroform Chloroform-d
Triphenyl phosphate beta-Sitosterol Phenol:chloroform:isoamyl alc. 25:24:1 Chloroform-d + 1% TMS (v/v) 0.1% ETHYLBENZENE IN CHLOROFORM-D (540 PP TUBE)
30% MENTHOL IN CHLOROFORM-D CHLOROFORM-13C, 99 ATOM % 13C 10% ETHYLBENZENE IN CHLOROFORM-D (540 PP TUBE)

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Deuterotrichloromethane trichloro-deuterio-methane CHLOROFORM-D >99.95 (ATOM % D) STAB. CHLOROFORM-D, "100" (MIN. 99.96 ATOM % D)(1PK=10 X 0.75ML) CHLOROFORM-D, "100" (MIN. 99.96 ATOM % D)(1PK=10 X 0.25ML) Chloroform-d, 99.8 atom % D, anhydrous CHLOROFORM-D, 99.8 ATOM % D(CONTAINS 1%V/V TMS) CHLOROFORM-D, 99.8 ATOM % D, STABILIZEDWITH 0.5 WT% SILVER FOIL (CONTAINS 0.03%( CHLOROFORM-D, "100" (MIN. 99.96 ATOM % D) CONTAINS 0.03% V/V TMS(1PK=10 X 0.75ML CHLOROFORM-D, 99.9 ATOM % D (CONTAINS 0.03% V/V TMS) CHLOROFORM-D, 99.8 ATOM % D (CONTAINS 0.03% V/V TMS) CHLOROFORM-D, "100" (MIN. 99.96 ATOM % D) CONTAINS 0.03% V/V TMS Chloroform-D,IsotopicPurity>99Atom%D Chloroform-d, isotopic purity Chloroform-d,100%D(Isotopic),contains0.03%v/vTMS Chloroform-d,99.8%(Isotopic),contains0.03%v/vTMS Chloroform-d, 100 atom % D, packaged in 0.75 ml ampules, for NMR Chloroform-d, 100.0 atom % D, for NMR Chloroform-d, 100.0 atom % D, packaged in 0.50 ml ampules, for NMR Chloroform-d, 99.6+ atom % D, for NMR Chloroform-d, 99.8 atom % D, contains 1 v/v% TMS, for NMR Chloroform-d, 99.8 atom % D, for NMR Chloroform-d, 99.8 atom % D, packaged in 0.75 ml ampules, for NMR Chloroform-d, 99.8 atom % D, packaged in 1 ml ampules, for NMR Chloroform-d, 99.8 atom % D, stabilized with silver foil, for NMR Chloroform-d, 99.8% D, stabilized with silver foil, 1 v/v% TMS, for NMR Chloroform-d, 99.8+ atom % D, contains 0.03 v/v% TMS, for NMR Chloroform-d, 99.8+% D, stab. with silver foil, 0.03 v/v% TMS, for NMR ChloroformD>99.96%10x0.75ml ChloroformD>99.96%+0.03%tms ChloroformD>99.8%+0.03%tms ChloroformD>99.8%10x0.75ml ChloroformD>99.8%5x10ml ChloroformD>99.96%10x0.6ml ChloroformD>99.96% ChloroformD>99.96%10x0.75ml(+0.03%tms) Chloroform-d,for NMR,100.0 atom % D, packagedin 0.50 ml ampules Chloroform-d,for NMR,99.8+ atom % D, contains0.03 v/v% TMS Chloroform-d,for NMR,contains 0.03 v/v% TMS,99.8+ atom % D Chloroform-d,for NMR,99.8 atom % D Chloroform-d,for NMR,99.6+ atom % D Chloroform-d,for NMR,99.8 atom % D, contains1 v/v% TMS Chloroform-d,for NMR,99.8% D, stabilized withsilver foil, 1 v/v% TMS Chloroform-d,for NMR,100 atom % D, packaged in 0.75 ml ampules Chloroform-d,for NMR,99.8 atom % D, packagedin 1 ml ampules Chloroform-d,for NMR,99.8+% D, stab. with silver foil, 0.03 v/v% TMS Chloroform-d,for NMR,99.8 atom % D, packagedin 0.75 ml ampules Chloroform-d,for NMR,99.8 atom % D, stabilized with silver foil Chloroform-d,Deuterochloroform Chloroform-d "100%" - DELETED Chloroform-d, (D99.8%)+TMS(0.03%) Chloroform-d, 100 atom % D, packaged in 0.75 ml ampoules, for NMR Chloroform-d, 99.8 atom % D, packaged in 0.75 ml ampoules, for NMR Chloroform-d, 99.8 atom % D, packaged in 1 ml ampoules, for NMR Chloroform-d, 99.8 atom % D, AcroSeal, for NMR ChloroforM-d, for NMR, 99.8 atoM % D, packaged in 1 Ml aMpoules ChloroforM-d, for NMR, 100 atoM % D, packaged in 0.75 Ml aMpoules CHLOROFORM-D1 DEUTERATION DEGREE MIN. 99