ChemicalBook >> CAS DataBase List >>Chloroform-d

Chloroform-d

Chloroform-d structure

CAS No.: 865-49-6

Chemical Name:: Chloroform-d

Synonyms: deuterated chloroform;CHLOROFORM-D1;Deuteriochloroform;Deuterotrichloromethane;Methane-d, trichloro-;Chloroform-d, 99.8 atom % D, anhydrous;CHLOROFORM-D, 99.8 ATOM % D(CONTAINS 1%V/V TMS);Chloroform-d,for NMR,100.0 atom % D, packagedin 0.50 ml ampules;CDCL3;oroform-d

CBNumber:: CB2103569

Molecular Formula:: CCl3D

Molecular Weight:: 120.38

MDL Number:: MFCD00000827

MOL File:: 865-49-6.mol

MSDS File:: SDS

Last updated:2026-01-13 11:13:54

Product description	Number	Pack Size	Price
Chloroform-D1 deuteration degree min. 99.8% for NMR spectroscopy (stabilized with silver) MagniSolv?	1.03420	25mL	$45.6
Chloroform-D1 deuteration degree min. 99.8% for NMR spectroscopy (stabilized with silver) MagniSolv?	1.03420	100mL	$114
Chloroform-D1 deuteration degree min. 99.8% for NMR spectroscopy (stabilized with silver) MagniSolv?	1.03420	500mL	$473
Chloroform-D1 0.03 vol.% TMS, deuteration degree min. 99.8% for NMR spectroscopy (stabilized with silver) MagniSolv?	1.03296	100mL	$109
Chloroform-D1 0.03 vol.% TMS, deuteration degree min. 99.8% for NMR spectroscopy (stabilized with silver) MagniSolv?	1.03296	500mL	$451
More product size

Request For Quotation

Chloroform-d Properties

Melting point	-63,5°C
Boiling point	61-62°C
Density	d = 1,5
vapor pressure	211 hPa (20 °C)
refractive index	n20/D 1.444(lit.)
Flash point	62°C
storage temp.	Store at +2°C to +8°C.
solubility	Miscible with organic solvents, ethyl acetate and acetone.
form	Liquid
color	White to beige
Specific Gravity	1.505
Water Solubility	4.6g/L
Sensitive	Moisture Sensitive
BRN	1697633
Exposure limits	ACGIH: TWA 10 ppm OSHA: Ceiling 50 ppm(240 mg/m3) NIOSH: IDLH 500 ppm; STEL 2 ppm(9.78 mg/m3)
Stability	Stable. Incompatible with strong bases, alkali metals, aluminium, magnesium, strong oxidizing agents.
InChI	1S/CHCl3/c2-1(3)4/h1H/i1D
InChIKey	HEDRZPFGACZZDS-MICDWDOJSA-N
SMILES	[2H]C(Cl)(Cl)Cl
LogP	1.5-1.6 at 20-23℃ and pH9
Surface tension	72.3mN/m at 998.5mg/L and 20℃
CAS DataBase Reference	865-49-6(CAS DataBase Reference)
FDA UNII	P1NW4885VT
EPA Substance Registry System	Chloroform-d (865-49-6)
UNSPSC Code	12142201
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H302-H315-H319-H331-H336-H351-H361d-H372

Precautionary statements

P201-P301+P312-P302+P352-P304+P340+P311-P305+P351+P338-P308+P313

target organs

Central nervous system, Liver,Kidney

PPE

Eyeshields, Faceshields, Gloves

Hazard Codes

Xn,T

Risk Statements

22-38-40-48/20/22-48/20-36/38-20/22-63

Safety Statements

36/37

RIDADR

UN 1888 6.1/PG 3

WGK Germany

HazardClass

6.1

PackingGroup

III

HS Code

28459000

Hazard Classifications

Acute Tox. 3 Inhalation
Acute Tox. 4 Oral
Carc. 2
Eye Irrit. 2
Repr. 2
Skin Irrit. 2
STOT RE 1 Oral
STOT SE 3

Toxicity

LD50 orally in Rabbit: 695 mg/kg LD50 dermal Rabbit > 3980 mg/kg

Limited Quantities

5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	1
3		1

Chloroform-d price More Price(138)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	1.03420	Chloroform-D1 deuteration degree min. 99.8% for NMR spectroscopy (stabilized with silver) MagniSolv?	865-49-6	25mL	$45.6	2025-07-31	Buy
Sigma-Aldrich	1.03420	Chloroform-D1 deuteration degree min. 99.8% for NMR spectroscopy (stabilized with silver) MagniSolv?	865-49-6	100mL	$114	2025-07-31	Buy
Sigma-Aldrich	1.03420	Chloroform-D1 deuteration degree min. 99.8% for NMR spectroscopy (stabilized with silver) MagniSolv?	865-49-6	500mL	$473	2025-07-31	Buy
Sigma-Aldrich	1.03296	Chloroform-D1 0.03 vol.% TMS, deuteration degree min. 99.8% for NMR spectroscopy (stabilized with silver) MagniSolv?	865-49-6	100mL	$109	2025-07-31	Buy
Sigma-Aldrich	1.03296	Chloroform-D1 0.03 vol.% TMS, deuteration degree min. 99.8% for NMR spectroscopy (stabilized with silver) MagniSolv?	865-49-6	500mL	$451	2025-07-31	Buy

Product number	Packaging	Price	Buy
1.03420	25mL	$45.6	Buy
1.03420	100mL	$114	Buy
1.03420	500mL	$473	Buy
1.03296	100mL	$109	Buy
1.03296	500mL	$451	Buy

Chloroform-d Chemical Properties,Uses,Production

Water peak

The position of the water peak in different deuterated reagents is not the same. The water peak of heavy water is about 4.67 ppm. There is a trend that the more water the low field.
Chloroform-D is less soluble with water and the water content is low, so its water peak near 1.59 ppm. Deuterated acetone is about 2.8 ppm and the deuterated dimethylsulfoxide has a water peak of about 3.4 ppm. If water is added to deuterated acetone, the water peak will gradually move to a low field and eventually stop at about 4.7 ppm.

Application

Chloroform-d has been employed as solvent in a 1H NMR (Proton Nuclear Magnetic Resonance) spectroscopic study. It has been employed as solvent during the 31PNMR (Phosphorus-31 nuclear magnetic resonance) spectral investigation of triphenyl phosphate and tris(2-chloroethyl) phosphate. It has also been used as the deuterated solvent in the 1H NMR spectral studies of 2-(4-bromobenzyl)-3-hydroxypropanoic acid and 3-hydroxy-2-(4-methoxybenzyl)propanoic acid. It has also been used as the deuterated solvent for the 1HNMR spectral studies of 3,3′-dihydroxy-4,4′-diamino-biphenyl (HAB) and 2,2′-bis-(3,4-dicarboxy-phenyl) hexafluoropropane dianhydride (6FDA) polyimide.Chloroform-d has been employed as solvent in a 1H NMR (Proton Nuclear Magnetic Resonance) spectroscopic study. It has been employed as solvent during the 31PNMR (Phosphorus-31 nuclear magnetic resonance) spectral investigation of triphenyl phosphate and tris(2-chloroethyl) phosphate. It has also been used as the deuterated solvent in the 1H NMR spectral studies of 2-(4-bromobenzyl)-3-hydroxypropanoic acid and 3-hydroxy-2-(4-methoxybenzyl)propanoic acid. It has also been used as the deuterated solvent for the 1HNMR spectral studies of 3,3′-dihydroxy-4,4′-diamino-biphenyl (HAB) and 2,2′-bis-(3,4-dicarboxy-phenyl) hexafluoropropane dianhydride (6FDA) polyimide.

Description

Deuterated chloroform (CDCl3), also known as chloroform-d, is an excellent everyday solvent choice for scientists who demand exceptional results. Commonly used as a solvent in proton NMR (1H NMR) spectroscopy, chloroform-d can dissolve a vast array of compounds with ease due to its weak polarity. It is often used in combination with methanol-d as a cosolvent. Plus, its low boiling point makes it relatively easy to recover a sample post-NMR analysis or during organic syntheses.

Chemical Properties

colourless liquid

Uses

Labelled Chloroform, generally in trimethylsilane solution, used in NMR spectroscopy as a solvent. Unlabelled chloroform has been used an an anaesthetic due to its action on the central nervous system .

Uses

Chloroform-d is widely used in the organic solvent for the NMR analysis.

Uses

Chloroform-d may be used in the synthesis of dichlorofluoromethane-d (DCFM).

Definition

ChEBI: Deuterated chloroform is a deuterated compound that is an isotopologue of chloroform in which the hydrogen atom is replaced with deuterium. Commonly used as a solvent in proton NMR spectroscopy. It has a role as a non-polar solvent, a NMR solvent and a NMR chemical shift reference compound. It is a deuterated compound and a member of chloromethanes.

Preparation

On a large-scale, chloroform-d (CDCl3) is synthesized by treatment of a hypochlorite salt with deuterated acetone/ethanol or the reaction between chloral and sodium deuteroxide (NaOD). The NaOD is prepared from the reaction of deuterium oxide (D2O) and sodium metal, which liberate deuterium gas from the reaction mixture; therefore, this reaction has drawbacks, including the danger of explosion of the deuterium gas and high risk for use of metal sodium on larger scales. In order to avoid the above drawbacks, the convenient reaction of sodium peroxide and D2O was used to prepare NaOD.
Production of Chloroform-d

General Description

Chloroform-d (Deuterochloroform, CDCl₃), deuterated chloroform, is a 100% isotopically enriched NMR (Nuclear Magnetic Resonance) solvent. It is widely employed in high resolution NMR studies due to its high chemical and isotopic purity. Quantitaive infrared spectral investigations of carbon-deuterium stretching bands of chloroform-d in various organic solvents have been reported. Raman difference spectroscopic studies of mixtures of chloroform-d and liquid chloroform have been conducted to evaluate frequency shifts in the in the ν₁ and ν₂ bands of CHCl₃ and CDCl₃.

References

[1] LIA ZAHARANI Mohd R B J, NADER GHAFFARI KHALIGH* Cost and Energy Saving Process for the Laboratory-Scale Production of Chloroform-d[J]. Organic Process Research & Development, 2022, 26 11: 3126-3129. DOI:10.1021/acs.oprd.2c00260.
[2] MEI-CHUN WU, HUA YANG* Photoredox-Catalyzed C–H Trideuteromethylation of Quinoxalin-2(1H)-ones with CDCl3 as the “CD3” source[J]. Organic Letters, 2022, 24 35: 6412-6416. DOI:10.1021/acs.orglett.2c02439.

Chloroform-d Preparation Products And Raw materials

Raw materials

SODIUM DEUTEROXIDE DEUTERIUM OXIDE Hexachloroacetone Calcium oxide

Preparation Products

4-AMINO-3-FORMYLPYRIDINE

Chloroform-d Suppliers

Global( 268)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Peric Technology Co.,Ltd	+86-0310-7183483 +8615030098277	jiake718@aliyun.com	China	36	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33325	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1006	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20128	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21599	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29833	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Richest Group Ltd	18017061086	oled@richest-group.com	CHINA	5600	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5742	58

Supplier	Advantage
Peric Technology Co.,Ltd	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Hangzhou ICH Biofarm Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
CONIER CHEM AND PHARMA LIMITED	58
Richest Group Ltd	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58

View Lastest Price from Chloroform-d manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-04	Chloroform-D 865-49-6	US $0.00 / kg	200kg	99%	plenty of stock	Hangzhou ICH Biofarm Co., Ltd
2025-12-15	Chloroform-d 865-49-6	US $0.00-0.00 / KG	1KG	98	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-09-25	Chloroform-d 865-49-6	US $100.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

Chloroform-D
865-49-6
US $0.00 / kg
99%
Hangzhou ICH Biofarm Co., Ltd

Chloroform-d
865-49-6
US $0.00-0.00 / KG
98
Shaanxi Dideu New Materials Co. Ltd

Chloroform-d
865-49-6
US $100.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

Chloroform-d Spectrum

Chloroform-d(865-49-6)MS Chloroform-d(865-49-6)¹HNMR Chloroform-d(865-49-6)¹³CNMR Chloroform-d(865-49-6)IR1 Chloroform-d(865-49-6)Raman

865-49-6(Chloroform-d)Related Search:

Ethyl (2,4,6-trimethylbenzoyl) phenylphosphinate 5α-Cholestane NMR REF STD, 0.0485M TRIPHENYLPHOSPHATE IN CHLOROFORM-D, 99.9 ATOM % D,NMR REF STD, 0.0485M TRIPHENYLPHOSPHATEIN CHLOROFORM-D,99.8 ATOM % D PHENOL:CHLOROFORM:ISOAMYLALCOHOL 49.5:49 .5:1,PHENOL:CHLOROFORM:ISOAMYL ALC. 125:24:1, FOR MOL. BIOLOGY BETA-SITOSTEROL 1X1ML CHLOROFORM 100UG/M L

Dichloromethane 100 MG/ML CHOLESTERYL ACETATE IN CHLOROFORM-D Chloroform Chloroform-d DICHLOROMETHANE D

CHLOROFORM-D + 1% TMS (V/V) ACETONE-D6 TRIS(DIBENZYLIDENEACETONE)DIPALLADIUM(0) CHLOROFORM ADDUCT 98+% Chlorobutanol METHANE (D1)

DEUTERIUM HYDRIDE 0.1% ETHYLBENZENE IN CHLOROFORM-D (540 PP TUBE) 30% MENTHOL IN CHLOROFORM-D

1of4

Deuterotrichloromethane Trichloro(2H)methane trichloro-deuterio-methane CHLOROFORM-D >99.95 (ATOM % D) STAB. CHLOROFORM-D, "100" (MIN. 99.96 ATOM % D)(1PK=10 X 0.75ML) CHLOROFORM-D, "100" (MIN. 99.96 ATOM % D)(1PK=10 X 0.25ML) Chloroform-d, 99.8 atom % D, anhydrous CHLOROFORM-D, 99.8 ATOM % D(CONTAINS 1%V/V TMS) CHLOROFORM-D, 99.8 ATOM % D, STABILIZEDWITH 0.5 WT% SILVER FOIL (CONTAINS 0.03%( CHLOROFORM-D, "100" (MIN. 99.96 ATOM % D) CONTAINS 0.03% V/V TMS(1PK=10 X 0.75ML CHLOROFORM-D, 99.9 ATOM % D (CONTAINS 0.03% V/V TMS) CHLOROFORM-D, 99.8 ATOM % D (CONTAINS 0.03% V/V TMS) CHLOROFORM-D, "100" (MIN. 99.96 ATOM % D) CONTAINS 0.03% V/V TMS Chloroform-D,IsotopicPurity>99Atom%D Chloroform-d, isotopic purity Chloroform-d,100%D(Isotopic),contains0.03%v/vTMS Chloroform-d,99.8%(Isotopic),contains0.03%v/vTMS Chloroform-d, 100 atom % D, packaged in 0.75 ml ampules, for NMR Chloroform-d, 100.0 atom % D, for NMR Chloroform-d, 100.0 atom % D, packaged in 0.50 ml ampules, for NMR Chloroform-d, 99.6+ atom % D, for NMR Chloroform-d, 99.8 atom % D, contains 1 v/v% TMS, for NMR Chloroform-d, 99.8 atom % D, for NMR Chloroform-d, 99.8 atom % D, packaged in 0.75 ml ampules, for NMR Chloroform-d, 99.8 atom % D, packaged in 1 ml ampules, for NMR Chloroform-d, 99.8 atom % D, stabilized with silver foil, for NMR Chloroform-d, 99.8% D, stabilized with silver foil, 1 v/v% TMS, for NMR Chloroform-d, 99.8+ atom % D, contains 0.03 v/v% TMS, for NMR Chloroform-d, 99.8+% D, stab. with silver foil, 0.03 v/v% TMS, for NMR ChloroformD>99.96%10x0.75ml ChloroformD>99.96%+0.03%tms ChloroformD>99.8%+0.03%tms ChloroformD>99.8%10x0.75ml ChloroformD>99.8%5x10ml ChloroformD>99.96%10x0.6ml ChloroformD>99.96% ChloroformD>99.96%10x0.75ml(+0.03%tms) Chloroform-d,for NMR,100.0 atom % D, packagedin 0.50 ml ampules Chloroform-d,for NMR,99.8+ atom % D, contains0.03 v/v% TMS Chloroform-d,for NMR,contains 0.03 v/v% TMS,99.8+ atom % D Chloroform-d,for NMR,99.8 atom % D Chloroform-d,for NMR,99.6+ atom % D Chloroform-d,for NMR,99.8 atom % D, contains1 v/v% TMS Chloroform-d,for NMR,99.8% D, stabilized withsilver foil, 1 v/v% TMS Chloroform-d,for NMR,100 atom % D, packaged in 0.75 ml ampules Chloroform-d,for NMR,99.8 atom % D, packagedin 1 ml ampules Chloroform-d,for NMR,99.8+% D, stab. with silver foil, 0.03 v/v% TMS Chloroform-d,for NMR,99.8 atom % D, packagedin 0.75 ml ampules Chloroform-d,for NMR,99.8 atom % D, stabilized with silver foil Chloroform-d,Deuterochloroform Chloroform-d "100%" - DELETED Chloroform-d, (D99.8%)+TMS(0.03%) Chloroform-d, 100 atom % D, packaged in 0.75 ml ampoules, for NMR Chloroform-d, 99.8 atom % D, packaged in 0.75 ml ampoules, for NMR Chloroform-d, 99.8 atom % D, packaged in 1 ml ampoules, for NMR Chloroform-d, 99.8 atom % D, AcroSeal, for NMR ChloroforM-d, for NMR, 99.8 atoM % D, packaged in 1 Ml aMpoules ChloroforM-d, for NMR, 100 atoM % D, packaged in 0.75 Ml aMpoules