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BOC-HYP-OL

BOC-HYP-OL structure

CAS No.: 61478-26-0

Chemical Name:: BOC-HYP-OL

Synonyms: TERT-BUTYL (2S,4R)-4-HYDROXY-2-(HYDROXYMETHYL)PYRROLIDINE-1-CARBOXYLATE;BOC-TRANS-4-HYDROXY-L-PROLINOL;(2S,4R)-tert-butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate; 61478-26-0;BOC-HYP-OL;Boc-Hydroxyprolinol;BOC-HYP-OL USP/EP/BP;BOC-PRO(4-HYDROXY)-OL;Boc-L-hydroxyprolinol;Boc-trans-4-hydroxy-L

CBNumber:: CB2110415

Molecular Formula:: C10H19NO4

Molecular Weight:: 217.26

MDL Number:: MFCD02094386

MOL File:: 61478-26-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:53:17

Product description	Number	Pack Size	Price
Boc-trans-4-hydroxy-L-prolinol 96%	546992	1g	$62.3
(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxymethyl)pyrrolidine >96.0%(GC)	B3662	1g	$40
(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxymethyl)pyrrolidine >96.0%(GC)	B3662	5g	$134
(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxymethyl)pyrrolidine Asreported	267022	500mg	$335
(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxymethyl)pyrrolidine Asreported	267022	1g	$469
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BOC-HYP-OL Properties

Melting point	81-86 °C (lit.)
alpha	-47o (C=1 IN CHLOROFORM)
Boiling point	340.3±27.0 °C(Predicted)
Density	1.190±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	14.57±0.40(Predicted)
color	White
optical activity	[α]20/D 47°, c = 1 in chloroform
Sensitive	Air Sensitive
Major Application	peptide synthesis
InChI	InChI=1S/C10H19NO4/c1-10(2,3)15-9(14)11-5-8(13)4-7(11)6-12/h7-8,12-13H,4-6H2,1-3H3/t7-,8+/m0/s1
InChIKey	UFJNFQNQLMGUTQ-JGVFFNPUSA-N
SMILES	N1(C(OC(C)(C)C)=O)C[C@H](O)C[C@H]1CO
CAS DataBase Reference	61478-26-0(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37

WGK Germany

HazardClass

IRRITANT

HS Code

29339900

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		0

BOC-HYP-OL price More Price(84)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	546992	Boc-trans-4-hydroxy-L-prolinol 96%	61478-26-0	1g	$62.3	2023-06-20	Buy
TCI Chemical	B3662	(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxymethyl)pyrrolidine >96.0%(GC)	61478-26-0	1g	$40	2026-04-30	Buy
TCI Chemical	B3662	(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxymethyl)pyrrolidine >96.0%(GC)	61478-26-0	5g	$134	2026-04-30	Buy
Usbiological	267022	(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxymethyl)pyrrolidine Asreported	61478-26-0	500mg	$335	2026-06-03	Buy
Usbiological	267022	(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxymethyl)pyrrolidine Asreported	61478-26-0	1g	$469	2026-06-03	Buy

Product number	Packaging	Price	Buy
546992	1g	$62.3	Buy
B3662	1g	$40	Buy
B3662	5g	$134	Buy
267022	500mg	$335	Buy
267022	1g	$469	Buy

BOC-HYP-OL Chemical Properties,Uses,Production

Chemical Properties

Viscous Oil

Uses

BOC-HYP-OL is a useful reactant used in the preparation of 4-purinylpyrrolidine nucleosides, kinase inhibitors and antibacterial agents.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

N-Boc-trans-4-Hydroxy-L-proline methyl ester

74844-91-0

61478-26-0

Under argon protection, 1-tert-butyl 2-methyl-(2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate (5.0 g, 20.41 mmol) was dissolved in THF (100 mL), cooled to -16 °C and stirred. LiAlH4 (1 M solution of THF, 21 mL, 21 mmol) was added slowly and dropwise over 5 min and precipitate formation was observed in the reaction. THF (50 mL) was subsequently added to destroy the precipitate. The reaction mixture was gradually warmed to 0 °C with stirring for 3.5 hours. Upon completion of the reaction, the reaction was quenched with EtOAc (5 mL) and stirring was continued for 30 minutes. Then, an excess of Rochelle's salt solution (100 mL) was carefully added, and the mixture was warmed to room temperature and stirred for an additional 1 hour. The mixture was extracted twice with CH2Cl2 (100 mL), the organic phases were combined, dried with MgSO4, filtered and concentrated under reduced pressure to remove the solvent. The product was purified by column chromatography (eluent: 10% MeOH/CH2Cl2) to give Intermediate 19 in quantitative yield.1H NMR (300 MHz, DMSO-d6) δ: 4.82 (br s, 1H), 4.64 (br d, J = 5.5 Hz, 1H), 4.20 (sxt, J = 4.2 Hz, 1H), 3.75 (br s , 1H), 3.16-3.50 (m, 4H), 1.85-2.02 (m, 1H), 1.80 (br s, 1H), 1.39 (s, 9H).

References

[1] Patent: WO2017/29521, 2017, A1. Location in patent: Page/Page column 37
[2] Journal of Medicinal Chemistry, 1991, vol. 34, # 9, p. 2787 - 2797
[3] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 1, p. 56 - 60
[4] Patent: US2014/256016, 2014, A1. Location in patent: Paragraph 0024; 0025
[5] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1989, vol. 28, # 1-11, p. 294 - 296

BOC-HYP-OL synthesis

Synthesis of BOC-HYP-OL from N-Boc-trans-4-Hydroxy-L-proline methyl ester

BOC-HYP-OL Preparation Products And Raw materials

Raw materials

Boc-Hyp-OH Di-tert-butyl dicarbonate 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) 2-(2-propen-1-yl) ester, (2S,4R)- N-Boc-trans-4-Hydroxy-L-proline methyl ester L-Hydroxyproline

Tetrahydrofuran Lithium Aluminum Hydride

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Preparation Products

2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)- 1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-4-methyl-, 1,1-dimethylethyl ester, (2S,4S)- (2S,4R)-tert-butyl 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidine-1-carboxylate (3S,5R)-4-Hydroxy-2-pyrrolidinemethanol

BOC-HYP-OL Suppliers

Global( 246)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +86-189 4982 3763	sales@tnjchem.com	China	34526	58
Dideu Industries Group Limited	+8617392712697	1022@dideu.com	China	29094	58
AFINE CHEMICALS LIMITED	+86-571-85134551 +86-18958018566	info@afinechem.com	China	15050	58
Finetech Industry Limited	+86-27-8746-5837 +86-18627785180	info@finetechnology-ind.com	China	9539	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52693	58
Henan Alfa Chemical Co., Ltd	+8618339805032	sale03@alfachem.cn	China	9858	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +8619957148339	market18@leapchem.com	China	24569	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
CONIER CHEM AND PHARMA LIMITED	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Finetech Industry Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Henan Alfa Chemical Co., Ltd	58
HANGZHOU LEAP CHEM CO., LTD.	58

View Lastest Price from BOC-HYP-OL manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-08-25	BOC-HYP-OL 61478-26-0	$60.00-500.00	5g	99%	50	Zibo Hangyu Biotechnology Development Co., Ltd
	2019-07-06	BOC-HYP-OL 61478-26-0	$1.00	1KG	98%	2kg	Career Henan Chemical Co

BOC-HYP-OL
61478-26-0
$60.00-500.00
99%
Zibo Hangyu Biotechnology Development Co., Ltd

BOC-HYP-OL
61478-26-0
$1.00
98%
Career Henan Chemical Co

BOC-HYP-OL Spectrum

BOC-HYP-OL(61478-26-0)¹HNMR

61478-26-0(BOC-HYP-OL)Related Search:

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BOC-HYP(BZL)-OH N-Boc-trans-4-tosyloxy-L-proline methyl ester N-Boc-cis-4-Hydroxy-L-proline methyl ester Boc-Hyp-OH N-Boc-trans-4-Hydroxy-L-proline methyl ester

(2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-PHENOXY-2-PYRROLIDINECARBOXYLIC ACID BOC-HYP-OH DCHA (2S,4R)-BOC-4-PHENOXY-PYRROLIDINE-2-CARBOXYLIC ACID

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(-)-N-BOC-L-4-HYDROXYPROLINOL N-BOC-TRANS-4-HYDROXY-L-PROLINOL N-T-BUTOXYCARBONYL-TRANS-4-HYDROXY-L-PROLINOL BOC-HYP-OL BOC-PRO(4-HYDROXY)-OL 1-Pyrrolidinecarboxylic acid, 4-hydroxy-2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S,4R)- 1-BOC-TRANS-4-HYDROXY-L-PROLINOL (2S,4R)-4-Hydroxy-2-hydroxymethyl-1-pyrrolidinecarboxylic acid tert-butyl ester （2S,4R）-tert-butyl-4-hydroxy-2-（hydroxymethyl）carboxylat Boc-L-hydroxyprolinol N-tert-Butoxycarbonyl-trans-4-hydroxy-L-prolinol (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxyMethyl)pyrrolidine (2S,4R)-tert-butyl 4-hydroxy-2-(hydroxyMethyl)pyrrolidine-1-carb tert-Butyl 2-hydroxy-2-((2S,4R)-4-hydroxypyrrolidin-2-yl)acetate (2S,4R)-1-Boc-4-hydroxy-2-(hydroxymethyl)pyrrolidine (2S,4R)-4-Hydroxy-2-(hydroxymethyl)pyrrolidine, N-BOC protected trans-4-Hydroxy-L-prolinol, N-BOC protected, tert-Butyl (2S,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate 1-Pyrrolidinecarboxylicacid, 4-hydroxy-2-(hydroxymethyl)- 61478-26-0 (2S,4R)-tert-butyl-4-hydroxy-2-(hydroxymethyl)carboxylate (4R)-1-Boc-4-hydroxy-L-prolinol (2S,4R)-N-Boc-4-hydroxy-2-(hydroxymethyl)pyrrolidine (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxymethyl)pyrrolidine > Boc-trans-4-hydroxy-L (2S,4R)-1-BOC-4-HYDROXY-2-(HYDROXYMETHYL)PYRROLINE (2S,4R)-4-Hydroxy-2-(hydroxymethyl)pyrrolidine BOC-HYP-OL USP/EP/BP Boc-Hydroxyprolinol (2S,4R)-N-Boc-2-hydroxymethyl-4-hydroxy-prrolidine 1,1-Dimethylethyl (2S,4R)-4-hydroxy-2-(hydroxymethyl)-1-pyrrolidinecarboxylate (2S,4R)-N-Boc-2-hydroxymethyl-4-hydroxy-pyrrolidine Boc-trans-4-hydroxy-L-prolinol (2S,4R)-tert-butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate BOC-TRANS-4-HYDROXY-L-PROLINOL TERT-BUTYL (2S,4R)-4-HYDROXY-2-(HYDROXYMETHYL)PYRROLIDINE-1-CARBOXYLATE 61478-26-0 Amino Alcohols Amino Acid Derivatives Peptide Synthesis Specialty Synthesis Amino Acid Derivatives Amino Alcohols Peptide Synthesis