ChemicalBook >> CAS DataBase List >>Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-

Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-

Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]- structure

CAS No.: 2281803-28-7

Chemical Name:: Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-

Synonyms: Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-

CBNumber:: CB211767484

Molecular Formula:: C36H37F5IN9O6

Molecular Weight:: 913.63

MDL Number:

MOL File:: 2281803-28-7.mol

Last updated:2025-04-18 09:51:46

Request For Quotation

Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]- Properties

Density	1+-.0.1 g/cm3(Predicted)
pka	4.46±0.10(Predicted)

Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]- Chemical Properties, Uses, Production

Uses

MEK/PI3K-IN-1 (compound 6r) is a potent MEK/PI3K inhibitor, with IC50 values of 124 nM (MEK1), 130 nM (PI3Kα), and 236 nM (PI3Kδ), respectively. MEK/PI3K-IN-1 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-1 shows anti-proliferative activity against tumor cell lines[1].

IC 50

MEK1: 124 ± 11 nM (IC₅₀); PI3Kα: 130 ± 13 nM (IC₅₀); PI3Kδ: 236 ± 29 nM (IC₅₀); PI3Kβ: 1537 ± 188 nM (IC₅₀); PI3Kγ: 2745 ± 485 nM (IC₅₀)

References

[1] Van Dort ME, et al. Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors. Eur J Med Chem. 2022 Feb 5;229:113996. DOI:10.1016/j.ejmech.2021.113996

Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

2281803-28-7 (Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-) Related Search:

Benzamide, N-[[12-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-14-hydroxy-3,6,9-trioxa-12-azatetradec-1-yl]oxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]- Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]- ST-168 Hyaluronic acid LY 294002 Hydrochloride

RMC6236

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Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]- 2281803-28-7 C36H37F5IN9O6