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Prucalopride

Prucalopride Structure
Prucalopride structure
CAS No.
179474-81-8
Chemical Name:
Prucalopride
Synonyms
CS-219;Resolor;R093877;R 093877;Prucalopride;Unii-0A09iuw5tp;Prucalopride, >=98%;Prucalopride(R-93877);Prucalopride, 99%min;Prucalopride USP/EP/BP
CBNumber:
CB21179613
Molecular Formula:
C18H26ClN3O3
Molecular Weight:
367.87
MDL Number:
MFCD09837787
MOL File:
179474-81-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:54:55
Product description Number Pack Size Price
Prucalopride ≥98% (HPLC) SML1371 10MG $79.7
Prucalopride ≥98% (HPLC) SML1371 50MG $323
Prucalopride P2467 10MG $48
Prucalopride P2467 50MG $141
Prucalopride ≥98% 24192 10mg $63
More product size
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Prucalopride Properties

Melting point 90.7°
Boiling point 481.4±45.0 °C(Predicted)
Density 1.28
storage temp. 2-8°C
solubility DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml
pka 13.65±0.20(Predicted)
form powder
color white to beige
InChI InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
InChIKey ZPMNHBXQOOVQJL-UHFFFAOYSA-N
SMILES O1C2=C(C(NC3CCN(CCCOC)CC3)=O)C=C(Cl)C(N)=C2CC1
FDA UNII 0A09IUW5TP
ATC code A06AX05
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Environment (GHS09)
GHS07,GHS09
Signal word  Warning
Hazard statements  H315-H319-H335-H400
Precautionary statements  P273-P302+P352-P305+P351+P338
target organs Respiratory system
RIDADR  UN 3077 9 / PGIII
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
Hazard Classifications Aquatic Acute 1
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

Prucalopride price More Price(67)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1371 Prucalopride ≥98% (HPLC) 179474-81-8 10MG $79.7 2026-04-30 Buy
Sigma-Aldrich SML1371 Prucalopride ≥98% (HPLC) 179474-81-8 50MG $323 2026-04-30 Buy
TCI Chemical P2467 Prucalopride 179474-81-8 10MG $48 2026-04-30 Buy
TCI Chemical P2467 Prucalopride 179474-81-8 50MG $141 2026-04-30 Buy
Cayman Chemical 24192 Prucalopride ≥98% 179474-81-8 10mg $63 2026-04-30 Buy
Product number Packaging Price Buy
SML1371 10MG $79.7 Buy
SML1371 50MG $323 Buy
P2467 10MG $48 Buy
P2467 50MG $141 Buy
24192 10mg $63 Buy

Prucalopride Chemical Properties,Uses,Production

Description

Prucalopride is a potent and selective agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Kis = 2.5 and 8 nM for human 5-HT4A and 5-HT4B, respectively). Prucalopride is greater than 250-fold selective for 5-HT4 over a panel of 53 overexpressed receptors, including 5-HT subtypes, but does bind to human dopamine D4 and sigma-1 (σ1) receptors and mouse 5-HT3 receptors (Kis = 2.3, 3.7, and 3.8 μM, respectively). It induces contractions in guinea pig colon with an EC50 value of 33 nM, an effect that is blocked by the 5-HT4 antagonist GR113808 but not the 5-HT2A and 5-HT3 antagonists ketanserin and granisetron , respectively. It also facilitates non-cholinergic contractions induced by electrical stimulation. In fasted dogs, oral administration of prucalopride increases colonic motility by inhibiting distal colon contractions (ED50 = 0.04 mg/kg), an effect that is blocked by pretreatment with the 5-HT4 antagonist GR125487. Prucalopride (5-10 mg/kg, s.c.) increases acetylcholine and histamine levels in the rat prefrontal cortex by 2.4-fold and 3-fold, respectively, and increases the power of hippocampal theta oscillations. Formulations containing prucalopride have been used in the treatment of chronic idiopathic constipation.

Definition

ChEBI: Prucalopride is a member of benzamides.

Biochem/physiol Actions

In healthy male individuals, prucalopride decreases the display of esophageal acid and promotes gastric emptying. It is effective, safe and shows good tolerance for the treatment of men with chronic constipation.

Mechanism of action

Prucalopride is a high affinity, highly selective 5-HT4 agonist. Its action in the treatment of chronic constipation is to stimulate intestinal peristalsis by specifically interacting with 5-HT4 receptors in the digestive tract, resulting in the release of acetylcholine, which further constricts the muscular layer of the colon, and the relaxation of the circular muscular layer promoting the expulsion of luminal contents.

Side effects

Prucalopride is usually well tolerated. The most common adverse reactions include: headache, nausea, abdominal pain and diarrhoea. Other adverse reactions that may occur include: abnormal stomach or bowel sounds, flatulence, decreased appetite, dizziness, unusual tiredness or weakness, pain in the extremities or chest, difficulty or inability to speak, difficulty breathing, and suicidal thoughts. Severe allergic reactions are rare and usually manifest as hives or lumps, itching, rash, redness of the skin, swelling of the face, and tightness in the chest.

Enzyme inhibitor

This novel enterokinetic drug (FW = 367.87 g/mol; CAS 179474-81-8), also known by the tradename Resolor and its systematic name, 4-amino-5- chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7- carboxamide, is a selective, high affinity serotonin 5-HT4 receptor agonist with that stimulates colonic mass movements, which provide the main propulsive force for defecation. It exhibits high affinity to both 5-HT4 receptor isoforms, with respective pKi values of 8.60 and 8.10 for the human 5-HT4A and 5-HT4B receptors. Based on 50 other binding assays,tonly the human D4 receptor (pKi = 5.63), the mouse 5-HT3 receptor (pKi = 5.41) and the human s1 (pKi = 5.43) shown measurable affinity, resulting in >290x selectivity for 5-HT4 receptors. Prucalopride also differs from other 5-HT4 agonists, such as tegaserod and cisapride, that interact with other receptors (5-HT1B/D and cardiac human ether-a-go-go K+ or hERG channel, respectively).

References

[1] Patent: CN106146386, 2016, A. Location in patent: Paragraph 0068; 0069; 0070; 0071

Prucalopride synthesis

179474-79-4
123654-26-2
179474-81-8
Synthesis of Prucalopride from 1-(3-Methoxypropyl)-4-piperidinamine and 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid

Prucalopride Preparation Products And Raw materials

Raw materials

4-aMino-5-chloro-2,3-dihydro-N-4-piperidinyl-7-BenzofurancarboxaMide 1-(3-Methoxypropyl)-4-piperidinamine 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid 3-Chloropropyl methyl ether 1,1'-Carbonyldiimidazole
Tetrahydrofuran

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Preparation Products

Prucalopride Suppliers

Global( 246)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Haibo Biotechnology Co., Ltd 		+86-18629295024 qinhe02@xaltbio.com China 996 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21533 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32997 60
Lianyungang happen teng technology co., LTD 		15950718863 wang666xt@163.com CHINA 293 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		0531-68652808 18953170293 sales@sdzschem.com China 2921 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 sales@amoychem.com China 6339 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
Nanjing Shizhou Biotechnology Co., Ltd 		+86-15850508050 sean.lv@synzest.com China 323 58
Supplier Advantage
Shaanxi Haibo Biotechnology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
Lianyungang happen teng technology co., LTD 		58
career henan chemical co 		58
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		58
Xiamen AmoyChem Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Nanjing Shizhou Biotechnology Co., Ltd 		58

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View Lastest Price from Prucalopride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Prucalopride pictures 2026-08-18 Prucalopride
179474-81-8
 1KG 99%min 100kg WUHAN FORTUNA CHEMICAL CO., LTD
Prucalopride pictures 2026-05-26 Prucalopride
179474-81-8
 $38.00-68.00 99.99% 10g TargetMol Chemicals Inc.
Prucalopride pictures 2024-04-12 Prucalopride
179474-81-8
 1kg 99% 2000ton Shaanxi Haibo Biotechnology Co., Ltd
  • Prucalopride pictures
  • Prucalopride
    179474-81-8
  • 99%min
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Prucalopride pictures
  • Prucalopride
    179474-81-8
  • $38.00-68.00
  • 99.99%
  • TargetMol Chemicals Inc.
  • Prucalopride pictures
  • Prucalopride
    179474-81-8
  • $0.00
  • 99%
  • Shaanxi Haibo Biotechnology Co., Ltd

Prucalopride Spectrum

Prucalopride(179474-81-8)1HNMR

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Prucalopride 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide 4-Amino-5-chloro-2,3-dihydro-N-(1-(3-methoxypropyl)-4-piperidyl)-7-benzofurancarboxamide R 093877 R093877 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide CS-219 Resolor Unii-0A09iuw5tp Prucalopride(R-93877) 7-BenzofurancarboxaMide, 4-aMino-5-chloro-2,3-dihydro-N-[1-(3-Methoxypropyl)-4-piperidinyl]- 4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide Prucalopride, >=98% Prucalopride, 99%, a 5-HT Receptor agonist Prucalopride USP/EP/BP Prucalopride (R-108512, R-93877) Prucalopride 13CD3Q: What is Prucalopride 13CD3 Q: What is the CAS Number of Prucalopride 13CD3 Q: What is the storage condition of Prucalopride 13CD3 Q: What are the applications of Prucalopride 13CD3 PrucaloprideQ: What is Prucalopride Q: What is the CAS Number of Prucalopride Q: What is the storage condition of Prucalopride Q: What are the applications of Prucalopride 4-Amino-5-chloro-N-[1-(3-methoxypropyl)-4-piperidyl]-2,3-dihydrobenzofuran-7-carboxamide Prucalopride, 10 mM in DMSO 4-amino-5-chloro-N-[1-(3-methoxypropyl) piperidin-4-yl]-2,3-dihydro-1- benzofuran-7-carboxamide monobutanedioate Prucalopride, 99%min 179474-81-8 Inhibitors API