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2-Amino-5-chlorobenzothiazole

2-Amino-5-chlorobenzothiazole Structure
2-Amino-5-chlorobenzothiazole structure
CAS No.
20358-00-3
Chemical Name:
2-Amino-5-chlorobenzothiazole
Synonyms
5-CHLOROBENZO[D]THIAZOL-2-AMINE;ASINEX-REAG BAS 00466316;5-Chlorobenzothiazol-2-amine;2-Amino-5-chlorobenzothiazol;2-Amino-5-chlorobenzthiazole;2-Bromo-11-methoxybenzoicacid;2-Amino-5-chlorobenzothiazole;2-Benzothiazolamine, 5-chloro-;5-chlrobenzo[d]thiazol-2-aMine;2-helium-5-hydrobenzophenazole
CBNumber:
CB2124522
Molecular Formula:
C7H5ClN2S
Molecular Weight:
184.65
MDL Number:
MFCD00205355
MOL File:
20358-00-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:50:12
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2-Amino-5-chlorobenzothiazole Properties

Melting point 199.0 to 203.0 °C
Boiling point 344.3±34.0 °C(Predicted)
Density 1.532±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility soluble in Methanol
form powder to crystal
pka 3.43±0.10(Predicted)
color White to Almost white
CAS DataBase Reference 20358-00-3(CAS DataBase Reference)
FDA UNII 3LL9WL723B

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280-P305+P351+P338-P362+P364
HS Code  29342000
Toxicity mouse,LD50,intravenous,92mg/kg (92mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 105, Pg. 486, 1952.
REACH Registrations Active
NFPA 704
0
2 0

2-Amino-5-chlorobenzothiazole price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical A3177 2-Amino-5-chlorobenzothiazole >98.0%(HPLC)(T) 20358-00-3 1g $50 2026-04-30 Buy
TCI Chemical A3177 2-Amino-5-chlorobenzothiazole >98.0%(HPLC)(T) 20358-00-3 5g $150 2026-04-30 Buy
AstaTech 50624 5-CHLOROBENZO[D]THIAZOL-2-AMINE 97% 20358-00-3 1G $29 2026-04-30 Buy
AstaTech 50624 5-CHLOROBENZO[D]THIAZOL-2-AMINE 97% 20358-00-3 5G $75 2026-04-30 Buy
AstaTech 50624 5-CHLOROBENZO[D]THIAZOL-2-AMINE 97% 20358-00-3 25G $235 2026-04-30 Buy
Product number Packaging Price Buy
A3177 1g $50 Buy
A3177 5g $150 Buy
50624 1G $29 Buy
50624 5G $75 Buy
50624 25G $235 Buy

2-Amino-5-chlorobenzothiazole Chemical Properties, Uses, Production

Chemical Properties

Colorless to light yellow solid

Uses

2-amino-5-chlorobenzothiazole is a heterocyclic compound used in pharmaceutical synthesis and experiments.

Synthesis

Potassium thiocyanate

333-20-0

3-Chloroaniline

108-42-9

2-AMINO-5-CHLOROBENZOTHIAZOLE

20358-00-3

General method: a solution of m-chloroaniline (2 mmol) in acetonitrile (15 ml) was slowly added to a solution of potassium thiocyanate (8 mmol) in acetonitrile (15 ml). Subsequently, 0.06 g (30 mol%) of BF3/SiO2 nanocatalyst was added to the reaction system and the mixture was placed in an ice salt bath and mechanically stirred for 30 min. A solution of bromine (4 mmol, 0.2 ml) in acetonitrile (3 ml) was slowly added through a dropping funnel, and the dropping rate was controlled to ensure that the reaction temperature did not exceed 0 °C. After the addition of the bromine solution, stirring was continued at 0 °C for 60 min, after which the reaction mixture was brought to room temperature and stirred for 4 h. The reaction was carried out by thin layer chromatography (TLC). The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was poured into water and heated to 70 °C on a steam bath followed by thermal filtration to remove the catalyst. The catalyst was washed with acetone and recycled for reuse. The filtrate was neutralized with 10% NaOH solution and the resulting precipitate was collected by filtration, dried and recrystallized from ethanol (10 ml) to give the target product 2-amino-5-chlorobenzothiazole. The structure of the product was confirmed by the following physical and spectral data and compared with known standards. In the case of 6-bromo-1,3-benzothiazol-2-amine (2e): yellow solid; yield = 93%; melting point = 202-204 °C (literature value 203 °C); FT-IR (KBr, cm^-1 ): 3315, 3012, 2835, 1580, 1476, 1261, 920, 742, 512; ^1H NMR (400 MHz, CDCl3, δ ppm): 5.44 (s, 2H, NH2), 7.4-7.5 (d, 2H, Ar-H), 7.71 (s, 1H, Ar-H); ^13C NMR (100 MHz, DMSO-d6, δ ppm): 119, 120.9, 125.15, 126.07, 133.1, 152.15, 167.75.

References

[1] Research on Chemical Intermediates, 2016, vol. 42, # 12, p. 7855 - 7868
[2] Asian Journal of Chemistry, 2011, vol. 23, # 9, p. 3969 - 3974
[3] Patent: WO2012/6068, 2012, A2. Location in patent: Page/Page column 118
[4] European Journal of Medicinal Chemistry, 2013, vol. 67, p. 1 - 13

2-Amino-5-chlorobenzothiazole Preparation Products And Raw materials

Raw materials

2-Benzothiazolamine,7-chloro-(9CI) 3-Chlorophenylthiourea Potassium thiocyanate 3-Chloroaniline Silicon monoxide

Preparation Products

2-Amino-5-chlorobenzothiazole Suppliers

Global Suppliers ( 166)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
China Langchem Inc. 0086-21-58956006 China 7798 57
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Energy Chemical 61
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Pure Chemistry Scientific Inc. 62
Shanghai Longsheng chemical Co.,Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
China DongFan Chemical Co.,LTD 66
Shandong Xiya Chemical Co., Ltd 57
Shanghai Ennopharm Co., Ltd. 65
China Langchem Inc. 57

View Latest Price from 2-Amino-5-chlorobenzothiazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-AMINO-5-CHLOROBENZOTHIAZOLE pictures 2019-07-10 2-AMINO-5-CHLOROBENZOTHIAZOLE
20358-00-3
 $1.00 1KG 98% 150KG Career Henan Chemical Co

2-Amino-5-chlorobenzothiazole Spectrum

2-AMINO-5-CHLOROBENZOTHIAZOLE(20358-00-3)1HNMR

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ASINEX-REAG BAS 00466316 5-CHLORO-1,3-BENZOTHIAZOL-2-AMINE 2-Benzothiazolamine,5-chloro-(9CI) 5-Chlorobenzothiazol-2-amine 5-chlrobenzo[d]thiazol-2-aMine 5-Chloro-benzothiazol-2-ylaMine 5-Chloro-2-benzo[d]thiazolamine 2-Amino-5-chlorobenzthiazole 2-Amino-5-chlorobenzothiazol 2-Benzothiazolamine, 5-chloro- 2-Amino-5-chlorobenzo[d]thiazole 2-Bromo-11-methoxybenzoicacid 2-helium-5-hydrobenzophenazole 5-CHLOROBENZO[D]THIAZOL-2-AMINE 2-Amino-5-chlorobenzothiazole 20358-00-3 C7H5ClN2S BENZOTHIAZOLE