Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide

Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide

Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide Structure
Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide structure
CAS No.
2492376-85-7
Chemical Name:
Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide
Synonyms
PI3K/mTOR Inhibitor-8;Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide
CBNumber:
CB212670969
Molecular Formula:
C23H22N8O4S
Molecular Weight:
506.54
MDL Number:
MOL File:
2492376-85-7.mol
MSDS File:
SDS
Last updated:2026-04-21 10:31:43
Request For Quotation

Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide Properties

Density 1.449±0.06 g/cm3(Predicted)
pka 9.41±0.43(Predicted)

Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide Chemical Properties,Uses,Production

Uses

PI3K/mTOR Inhibitor-8 (Compound 18b) is a PI3K and mTOR dual inhibitor with IC50 values of 0.46 nM and 12 nM against PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-8 induces HCT-116 cells apoptosis and arrests cell cycle at the G1/S phase[1].

IC 50

PI3Kα: 0.46 nM (IC50); mTOR: 12 nM (IC50)

References

[1] Han Y, et al. Design, synthesis and biological evaluation of thieno[3,2-d]pyrimidine derivatives containing aroyl hydrazone or aryl hydrazide moieties for PI3K and mTOR dual inhibition. Bioorg Chem. 2020 Nov;104:104197. DOI:10.1016/j.bioorg.2020.104197

Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2996 55
Nantong Hanfang Biotechnology Co. , Ltd. hanfangpharma@126.com 18017580634 hanfangpharma@126.com China 25800 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Shanghai Beckham Medical Technology Co., Ltd 55
Nantong Hanfang Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Lastest Price from Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PI3K/mTOR Inhibitor-8 pictures 2026-04-20 PI3K/mTOR Inhibitor-8
2492376-85-7
 $1520.00-2500.00 10g TargetMol Chemicals Inc.

2492376-85-7(Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide)Related Search:

Rapamycin Metformin Y-27632 Hyaluronic acid LY 294002 Hydrochloride
Quercetin

1of2

Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide PI3K/mTOR Inhibitor-8 2492376-85-7 C23H22N8O4S