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7-BROMO-5-FLUOROINDOLE

7-BROMO-5-FLUOROINDOLE structure

CAS No.: 408355-23-7

Chemical Name:: 7-BROMO-5-FLUOROINDOLE

Synonyms: 7-BROMO-5-FLUOROINDOLE;7-bromo-5-fluoro-1H-indene;1H-Indole, 7-broMo-5-fluoro-;7-Bromo-5-fluoro-1H-indole 97%

CBNumber:: CB2129350

Molecular Formula:: C8H5BrFN

Molecular Weight:: 214.03

MDL Number:: MFCD04037875

MOL File:: 408355-23-7.mol

MSDS File:: SDS

Last updated:2026-05-27 23:55:10

Product description	Number	Pack Size	Price
7-Bromo-5-fluoroindole 95%	754374	500mg	$109
7-Bromo-5-fluoro-1H-indole 97%	AS188590	1g	$70
7-Bromo-5-fluoro-1H-indole 97%	AS188590	5g	$322
7-Bromo-5-fluoro-1H-indole 97%	AS188590	25g	$1312
7-Bromo-5-fluoro-1H-indole 97.0%	B23568	100mg	$18

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7-BROMO-5-FLUOROINDOLE Properties

Melting point	20-25°C
Boiling point	315.1±22.0 °C(Predicted)
Density	1.750±0.06 g/cm3(Predicted)
Flash point	>110℃
storage temp.	2-8°C
pka	14.49±0.30(Predicted)
form	solid
Appearance	Off-white to light brown <20°C Solid,>25°C Liquid
Sensitive	Light Sensitive
InChI	1S/C8H5BrFN/c9-7-4-6(10)3-5-1-2-11-8(5)7/h1-4,11H
InChIKey	XOMFQRPHXMTJSG-UHFFFAOYSA-N
SMILES	FC1=CC2=C(NC=C2)C(Br)=C1
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H315-H318-H335

Precautionary statements

P280-P301+P312+P330-P302+P352-P305+P351+P338+P310

target organs

Respiratory system

Hazard Codes

Xi,Xn

Risk Statements

22-37/38-41

Safety Statements

26-36/37/39

WGK Germany

HazardClass

IRRITANT

HS Code

2933998090

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

7-BROMO-5-FLUOROINDOLE price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	754374	7-Bromo-5-fluoroindole 95%	408355-23-7	500mg	$109	2023-06-20	Buy
Activate Scientific	AS188590	7-Bromo-5-fluoro-1H-indole 97%	408355-23-7	1g	$70	2026-06-04	Buy
Activate Scientific	AS188590	7-Bromo-5-fluoro-1H-indole 97%	408355-23-7	5g	$322	2026-06-04	Buy
Activate Scientific	AS188590	7-Bromo-5-fluoro-1H-indole 97%	408355-23-7	25g	$1312	2026-06-04	Buy
Synthonix	B23568	7-Bromo-5-fluoro-1H-indole 97.0%	408355-23-7	100mg	$18	2026-05-06	Buy

Product number	Packaging	Price	Buy
754374	500mg	$109	Buy
AS188590	1g	$70	Buy
AS188590	5g	$322	Buy
AS188590	25g	$1312	Buy
B23568	100mg	$18	Buy

7-BROMO-5-FLUOROINDOLE Chemical Properties,Uses,Production

Uses

7-Bromo-5-fluoroindole is an HIV-1 attachment inhibitor.

Synthesis

1003-98-1

107-14-2

107-06-2

408355-23-7

(a) Synthesis of 5-fluoro-7-bromoindole. 2-Bromo-4-fluoroaniline (13.8 g, 72.6 mmol) was slowly added dropwise to a dichloromethane solution of boron trichloride (1.0 M, 81.1 mL, 81.1 mmol) cooled in ice water. The reaction mixture was gradually warmed to room temperature with continuous stirring for 30 minutes. Subsequently, chloroacetonitrile (13.5 mL, 87.1 mmol), aluminum chloride (13.5 g, 98.4 mmol) and 1,2-dichloroethane (95 mL) were added sequentially. The reaction system was heated to 70 °C to evaporate the dichloromethane, followed by refluxing the reaction for 24 hours. Upon completion of the reaction, it was cooled to 0-5 °C, 2.5 M HCl (130 mL) was carefully added and heated to 80 °C and kept at 80 °C for 1 h until the solid was completely dissolved. The aqueous layer was separated and the organic phase was extracted with dichloromethane. The organic layers were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate and concentrated to give a yellow solid (11 g, 56.9% yield), which could be used directly in the next reaction. The crude was dissolved in a solvent mixture of dioxane (68 mL) and water (7.6 mL) and sodium borohydride (1.64 g) was added in batches. The reaction was carried out at room temperature for 30 minutes to confirm complete consumption of the raw material and then heated to reflux for 18 hours. The reaction solution was cooled to room temperature, treated sequentially with 0.1 N HCl (70 mL), 2 N HCl (20 mL) and concentrated HCl (15 mL) and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous sodium sulfate and concentrated. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to afford 5-fluoro-7-bromoindole (4.4 g, 52.2% yield).1H NMR (400 MHz, CDCl3) δ 6.49 (dd, J = 2.35, 3.13 Hz, 1H), 7.06 (d, J = 2.35, 8.60 Hz, 1H), 7.14- 7.17 (m, 2H), 8.18 (br, 1H); MS (ES, m/z): C8H5BrFN [M+] calcd for 79Br: 211.9, found: 211.9; calcd for 81Br: 214.0, found: 214.0.

References

[1] Patent: US2004/48915, 2004, A1

7-BROMO-5-FLUOROINDOLE Preparation Products And Raw materials

Raw materials

2-Bromo-4-fluoroaniline Chloroacetonitrile 1,2-Dichloroethane Boron trichloride Water

Hydrochloric acid 1,4-Dioxane Dichloromethane

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Preparation Products

5-Fluoroindole 5-fluoro-1H-indole-7-carboxylic acid

7-BROMO-5-FLUOROINDOLE Suppliers

Global( 87)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	+8618795957998	karmelhk@126.com	CHINA	2886	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52693	58
CR Corporation Limited		fred.wen@crcorporation.cn	China	8642	58
PT CHEM GROUP LIMITED	+86-85511178; +86-85511178	peter68@ptchemgroup.com	China	35405	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49859	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501	product@acmec-e.com	China	33301	58
Aladdin Scientific		tp@aladdinsci.com	United States	50108	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40048	58
Allfluoro Pharmaceutical Company Limited	+86-400-0216110 +86-15958047586	sales@allfluoro.com	China	11380	58

Supplier	Advantage
Alchem Pharmtech,Inc.	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
CR Corporation Limited	58
PT CHEM GROUP LIMITED	58
GIHI CHEMICALS CO.,LIMITED	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
Allfluoro Pharmaceutical Company Limited	58

7-BROMO-5-FLUOROINDOLE Spectrum

7-BROMO-5-FLUOROINDOLE(408355-23-7)¹HNMR

408355-23-7(7-BROMO-5-FLUOROINDOLE)Related Search:

1H-INDOLE,7-BROMO-2,3-DIHYDRO- 4-Cyanoindole 7-Nitroindole 7-Bromoindole 5-Fluoroindole

6-Bromo-5-fluoroindole 5-BROMO-3-FLUOROINDOLE 7-BROMO-5-FLUOROINDOLE 7-bromo-4,5-difluoro-1H-indole 4-BROMO-7-FLUOROINDOLE

7-BROMO-4-FLUOROINDOLE 4-BROMO-6-FLUOROINDOLE 7-Bromo-6-fluoroindole 5-BROMO-7-FLUOROINDOLE N-[2-(7-BROMO-5-FLUORO-2-METHYL-1H-INDOL-3-YL)ETHYL]-N'-(4-METHOXYPHENYL)THIOUREA

N-[2-(7-BROMO-5-FLUORO-2-METHYL-1H-INDOL-3-YL)ETHYL]-N'-CYCLOHEXYLTHIOUREA ETHYL[7-FLUORO-5-BROMO-1,2,3,4-TETRAHYDRO-CYCLOPENTA[B]INDOL-3-YL]ACETATE N-[2-(7-BROMO-5-FLUORO-2-METHYL-1H-INDOL-3-YL)ETHYL]-N'-(2-PHENYLETHYL)THIOUREA

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7-BROMO-5-FLUOROINDOLE 1H-Indole, 7-broMo-5-fluoro- 7-bromo-5-fluoro-1H-indene 7-Bromo-5-fluoro-1H-indole 97% 408355-23-7