4-Bromo-2,3-difluorophenol
- CAS No.
- 144292-32-0
- Chemical Name:
- 4-Bromo-2,3-difluorophenol
- Synonyms
- 2FPBr;4-Bromo-2,3-difluoro;4-BROMO-2,3-DIFLUORPHENOL;4-BROMO-2,3-DIFLUOROPHENOL;2,3-DIFLUORO-4-BROMOPHENOL;Phenol, 4-bromo-2,3-difluoro-;4-Bromo-2,3-difluorophenol>2,3-DIFLUORO-4-BROMO PHENOL,=98%;4-Bromo-2,3-difluorophenol Aldrich;4-Bromo-2,3-difluorophenol AldrichCPR
- CBNumber:
- CB2149886
- Molecular Formula:
- C6H3BrF2O
- Molecular Weight:
- 208.99
- MDL Number:
- MFCD08061907
- MOL File:
- 144292-32-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 53.0 to 57.0 °C |
|---|---|
| Boiling point | 213.3±35.0 °C(Predicted) |
| Density | 1.858±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 7.16±0.23(Predicted) |
| form | powder to crystal |
| color | White to Gray to Brown |
| InChI | InChI=1S/C6H3BrF2O/c7-3-1-2-4(10)6(9)5(3)8/h1-2,10H |
| InChIKey | JZAVCMMYGSROJP-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=C(Br)C(F)=C1F |
| CAS DataBase Reference | 144292-32-0(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H301-H335 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501-P261-P280a-P301+P310a-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | 2811 | |||||||||
| HazardClass | IRRITANT | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2908190090 | |||||||||
| Storage Class | 6.1D - Non-combustible acute toxic Cat.3 toxic hazardous materials or hazardous materials causing chronic effects |
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| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| NFPA 704 |
|
4-Bromo-2,3-difluorophenol price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D3913 | 4-Bromo-2,3-difluorophenol >98.0%(GC)(T) | 144292-32-0 | 1g | $17 | 2026-04-30 | Buy |
| TCI Chemical | D3913 | 4-Bromo-2,3-difluorophenol >98.0%(GC)(T) | 144292-32-0 | 5g | $48 | 2026-04-30 | Buy |
| AstaTech | 21730 | 4-BROMO-2,3-DIFLUORO-PHENOL 97% | 144292-32-0 | 5G | $52 | 2026-04-30 | Buy |
| AstaTech | 21730 | 4-BROMO-2,3-DIFLUORO-PHENOL 97% | 144292-32-0 | 25G | $115 | 2026-04-30 | Buy |
| AstaTech | 21730 | 4-BROMO-2,3-DIFLUORO-PHENOL 97% | 144292-32-0 | 100G | $284 | 2026-04-30 | Buy |
4-Bromo-2,3-difluorophenol Chemical Properties,Uses,Production
Chemical Properties
white solid
Uses
4-Bromo-2,3-difluorophenol is used as medical intermediate.
Synthesis
406482-22-2
144292-32-0
The general procedure for the synthesis of 2,3-difluoro-4-bromophenol from 4-bromo-2,3-difluoroanisole was as follows: to a stirred solution of 1-bromo-2,3-difluoro-4-methoxybenzene (3 g, 13.45 mmol) in dichloromethane (DCM, 30 mL) was slowly added dropwise to a dichloromethane (DCM) solution of 1 M boron tribromide (BBr3) (26.9) at -20 °C. The dropwise addition time was controlled to 10 min. mL, 26.9 mmol), and the dropwise addition time was controlled over 10 min. The cooling bath was removed and the reaction mixture was continued to be stirred at room temperature for 12 hours. Subsequently, the reaction mixture was cooled to 10 °C and the reaction was quenched with saturated aqueous sodium bicarbonate solution (100 mL). The mixture was diluted with dichloromethane (DCM, 150 mL) and the organic layer was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 4-bromo-2,3-difluorophenol (2 g, 9.47 mmol, 70% yield) in the form of a dark red oil. NMR hydrogen spectrum (400MHz, chloroform-d): δ 7.15-7.21 (m, 1H), 6.69-6.76 (m, 1H), 5.30-5.31 (m, 1H) ppm.
References
[1] Patent: WO2017/59085, 2017, A1. Location in patent: Page/Page column 453
4-Bromo-2,3-difluorophenol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuxi Renyi New Materials Technology Co., Ltd | 13306222239 | wangmeili@renyiam.com | China | 558 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
View Lastest Price from 4-Bromo-2,3-difluorophenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-08-19 | 4-Bromo-2,3-difluorophenol
144292-32-0
|
1KG | 99% | 1000 KG | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-03-20 | 4-Bromo-2,3-difluorophenol
144292-32-0
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2019-07-06 | 4-Bromo-2,3-difluorophenol
144292-32-0
|
$2.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 4-Bromo-2,3-difluorophenol
144292-32-0
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-Bromo-2,3-difluorophenol
144292-32-0
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-Bromo-2,3-difluorophenol
144292-32-0
- $2.00
- 99%
- Career Henan Chemical Co
