4-Bromo-2,3-difluorophenol
- CAS No.
- 144292-32-0
- Chemical Name:
- 4-Bromo-2,3-difluorophenol
- Synonyms
- 2FPBr;4-Bromo-2,3-difluoro;4-BROMO-2,3-DIFLUORPHENOL;4-BROMO-2,3-DIFLUOROPHENOL;2,3-DIFLUORO-4-BROMOPHENOL;Phenol, 4-bromo-2,3-difluoro-;4-Bromo-2,3-difluorophenol>2,3-DIFLUORO-4-BROMO PHENOL,=98%;4-Bromo-2,3-difluorophenol Aldrich;4-Bromo-2,3-difluorophenol AldrichCPR
- CBNumber:
- CB2149886
- Molecular Formula:
- C6H3BrF2O
- Molecular Weight:
- 208.99
- MDL Number:
- MFCD08061907
- MOL File:
- 144292-32-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Bromo-2,3-difluorophenol >98.0%(GC)(T) | D3913 | 1g | $17 |
| 4-Bromo-2,3-difluorophenol >98.0%(GC)(T) | D3913 | 5g | $48 |
| 4-BROMO-2,3-DIFLUORO-PHENOL 97% | 21730 | 5G | $52 |
| 4-BROMO-2,3-DIFLUORO-PHENOL 97% | 21730 | 25G | $115 |
| 4-BROMO-2,3-DIFLUORO-PHENOL 97% | 21730 | 100G | $284 |
| More product size | |||
| Melting point | 53.0 to 57.0 °C |
|---|---|
| Boiling point | 213.3±35.0 °C(Predicted) |
| Density | 1.858±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 7.16±0.23(Predicted) |
| form | powder to crystal |
| color | White to Gray to Brown |
| InChI | InChI=1S/C6H3BrF2O/c7-3-1-2-4(10)6(9)5(3)8/h1-2,10H |
| InChIKey | JZAVCMMYGSROJP-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=C(Br)C(F)=C1F |
| CAS DataBase Reference | 144292-32-0(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H301-H335 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501-P261-P280a-P301+P310a-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | 2811 | |||||||||
| HazardClass | IRRITANT | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2908190090 | |||||||||
| Storage Class | 6.1D - Non-combustible acute toxic Cat.3 toxic hazardous materials or hazardous materials causing chronic effects |
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| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| NFPA 704 |
|
4-Bromo-2,3-difluorophenol price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D3913 | 4-Bromo-2,3-difluorophenol >98.0%(GC)(T) | 144292-32-0 | 1g | $17 | 2026-04-30 | Buy |
| TCI Chemical | D3913 | 4-Bromo-2,3-difluorophenol >98.0%(GC)(T) | 144292-32-0 | 5g | $48 | 2026-04-30 | Buy |
| AstaTech | 21730 | 4-BROMO-2,3-DIFLUORO-PHENOL 97% | 144292-32-0 | 5G | $52 | 2026-04-30 | Buy |
| AstaTech | 21730 | 4-BROMO-2,3-DIFLUORO-PHENOL 97% | 144292-32-0 | 25G | $115 | 2026-04-30 | Buy |
| AstaTech | 21730 | 4-BROMO-2,3-DIFLUORO-PHENOL 97% | 144292-32-0 | 100G | $284 | 2026-04-30 | Buy |
4-Bromo-2,3-difluorophenol Chemical Properties,Uses,Production
Chemical Properties
white solid
Uses
4-Bromo-2,3-difluorophenol is used as medical intermediate.
Synthesis
406482-22-2
144292-32-0
The general procedure for the synthesis of 2,3-difluoro-4-bromophenol from 4-bromo-2,3-difluoroanisole was as follows: to a stirred solution of 1-bromo-2,3-difluoro-4-methoxybenzene (3 g, 13.45 mmol) in dichloromethane (DCM, 30 mL) was slowly added dropwise to a dichloromethane (DCM) solution of 1 M boron tribromide (BBr3) (26.9) at -20 °C. The dropwise addition time was controlled to 10 min. mL, 26.9 mmol), and the dropwise addition time was controlled over 10 min. The cooling bath was removed and the reaction mixture was continued to be stirred at room temperature for 12 hours. Subsequently, the reaction mixture was cooled to 10 °C and the reaction was quenched with saturated aqueous sodium bicarbonate solution (100 mL). The mixture was diluted with dichloromethane (DCM, 150 mL) and the organic layer was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 4-bromo-2,3-difluorophenol (2 g, 9.47 mmol, 70% yield) in the form of a dark red oil. NMR hydrogen spectrum (400MHz, chloroform-d): δ 7.15-7.21 (m, 1H), 6.69-6.76 (m, 1H), 5.30-5.31 (m, 1H) ppm.
References
[1] Patent: WO2017/59085, 2017, A1. Location in patent: Page/Page column 453
4-Bromo-2,3-difluorophenol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5600 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Shanghai Safer Pharmaceutical Technology Co., Ltd. | 021-31761238 | sales@saferph.com | CHINA | 897 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8740 | 58 |
View Lastest Price from 4-Bromo-2,3-difluorophenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 4-Bromo-2,3-difluorophenol
144292-32-0
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2019-07-06 | 4-Bromo-2,3-difluorophenol
144292-32-0
|
$2.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 4-Bromo-2,3-difluorophenol
144292-32-0
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-Bromo-2,3-difluorophenol
144292-32-0
- $2.00
- 99%
- Career Henan Chemical Co
