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4-Bromo-2,6-difluoroaniline

4-Bromo-2,6-difluoroaniline structure

CAS No.: 67567-26-4

Chemical Name:: 4-Bromo-2,6-difluoroaniline

Synonyms: BUTTPARK 22\07-66;Abesili impurity 10;4-Bromo-2,6-difluoro;Vandetanib Impurity 8;4-Bromo-2, 6-difluoroan;2,6-difluro-4-broMoaniline;4-Bromo-2,6-diflaoroaniline;4-BROMO-2,6-DIFLUOROANILINE;2,6-DIFLUORO-4-BROMOANILINE;BFQSQUAVMNHOEF-UHFFFAOYSA-N

CBNumber:: CB4249197

Molecular Formula:: C6H4BrF2N

Molecular Weight:: 208

MDL Number:: MFCD00013389

MOL File:: 67567-26-4.mol

MSDS File:: SDS

Last updated:2025-09-09 10:27:52

Product description	Number	Pack Size	Price
4-Bromo-2,6-difluoroaniline 98%	327867	5g	$93.8
4-Bromo-2,6-difluoroaniline >98.0%(GC)	B3220	1g	$65
4-Bromo-2,6-difluoroaniline >98.0%(GC)	B3220	5g	$159
4-Bromo-2,6-difluoroaniline >98.0%(GC)	B3220	25g	$536
4-Bromo-2,6-difluoroaniline	161254	5g	$460
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4-Bromo-2,6-difluoroaniline Properties

Melting point	63-65 °C (lit.)
Boiling point	188.2±35.0 °C(Predicted)
Density	1.788±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	1.11±0.10(Predicted)
form	Crystalline Powder
color	Brown
InChI	InChI=1S/C6H4BrF2N/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,10H2
InChIKey	BFQSQUAVMNHOEF-UHFFFAOYSA-N
SMILES	C1(N)=C(F)C=C(Br)C=C1F
CAS DataBase Reference	67567-26-4(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332-H315-H319-H335

Precautionary statements

P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338

Hazard Codes

Xn,Xi

Risk Statements

20/21/22-36/37/38

Safety Statements

26-36-36/37/39-22

WGK Germany

HazardClass

IRRITANT

HS Code

29214200

NFPA 704

	1
2		0

4-Bromo-2,6-difluoroaniline price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	327867	4-Bromo-2,6-difluoroaniline 98%	67567-26-4	5g	$93.8	2025-07-31	Buy
TCI Chemical	B3220	4-Bromo-2,6-difluoroaniline >98.0%(GC)	67567-26-4	1g	$65	2025-07-31	Buy
TCI Chemical	B3220	4-Bromo-2,6-difluoroaniline >98.0%(GC)	67567-26-4	5g	$159	2025-07-31	Buy
TCI Chemical	B3220	4-Bromo-2,6-difluoroaniline >98.0%(GC)	67567-26-4	25g	$536	2025-07-31	Buy
Usbiological	161254	4-Bromo-2,6-difluoroaniline	67567-26-4	5g	$460	2021-12-16	Buy

Product number	Packaging	Price	Buy
327867	5g	$93.8	Buy
B3220	1g	$65	Buy
B3220	5g	$159	Buy
B3220	25g	$536	Buy
161254	5g	$460	Buy

4-Bromo-2,6-difluoroaniline Chemical Properties,Uses,Production

Chemical Properties

Off-white crystalline

Uses

4-Bromo-2,6-difluoroaniline was used in synthesis of:

ammonium 5-bromo-7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate, fluorogenic derivatizating reagent for the determination of aminothiols by HPLC
olefin tolanes
1-(4-amino-3,5-difluoro)-2-(4-butyloxyphenyl)ethyne
4′′-n-butyloxy-3,5-difluoroterphenyl-4-amine
4-(3-methylbut-1-yn-3-ol)-2,6-difluoroaniline

Uses

4-Bromo-2,6-difluoroaniline is used in the preparation of potent, VEGF receptor tyrosine kinase inhibitors.

Synthesis

5509-65-9

67567-26-4

b) Preparation of Intermediate 2: Dissolve 2,6-difluoroaniline (3.0 g, 22.56 mmol) in acetic acid (10 mL). Bromine (1.2 mL) was slowly added dropwise to the above solution. The reaction mixture was stirred at room temperature for 15 minutes. After the reaction was completed, the solvent was evaporated under reduced pressure. The residue was neutralized with aqueous sodium carbonate and the aqueous phase was subsequently extracted with dichloromethane. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give Intermediate 2 in 92% yield.

References

[1] Angewandte Chemie - International Edition, 2016, vol. 55, # 4, p. 1544 - 1547
[2] Angew. Chem., 2016, vol. 128, # 4, p. 1569 - 1573,5
[3] Journal of Materials Chemistry C, 2016, vol. 4, # 23, p. 5326 - 5333
[4] Patent: WO2006/15985, 2006, A1. Location in patent: Page/Page column 54
[5] Patent: US6716491, 2004, B2

4-Bromo-2,6-difluoroaniline synthesis

Synthesis of 4-Bromo-2,6-difluoroaniline from 2,6-Difluoroaniline

4-Bromo-2,6-difluoroaniline Preparation Products And Raw materials

Raw materials

Potassium hydroxide Chloroform 2,6-Difluoroaniline Ethyl acetate Bromine

Sodium carbonate Acetic acid

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Preparation Products

1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)- 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 6-BROMO-2-CHLORO-4-FLUOROBENZOTHIAZOLE 4-Bromo-2,6-difluorobenzene sulfonamide 4-Bromo-2,6-difluorobenzonitrile

4-Bromo-2,6-difluoroaniline Suppliers

Global( 408)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Zhonghan Chemical Technology Co., LTD.	+undefined15066662237	3281004549@qq.com	China	291	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8757	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5244	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20130	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21604	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29840	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58

Supplier	Advantage
Jinan Zhonghan Chemical Technology Co., LTD.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58

View Lastest Price from 4-Bromo-2,6-difluoroaniline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-05	4-Bromo-2,6-difluoroaniline 67567-26-4	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-12-01	4-Bromo-2,6-difluoroaniline 67567-26-4	US $0.00-0.00 / KG	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-09-25	4-Bromo-2,6-difluoroaniline 67567-26-4	US $5.00-0.10 / KG	1KG	98%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

4-Bromo-2,6-difluoroaniline
67567-26-4
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Bromo-2,6-difluoroaniline
67567-26-4
US $0.00-0.00 / KG
98.0%
Shaanxi Dideu New Materials Co. Ltd

4-Bromo-2,6-difluoroaniline
67567-26-4
US $5.00-0.10 / KG
98%
Henan Fengda Chemical Co., Ltd

4-Bromo-2,6-difluoroaniline Spectrum

4-Bromo-2,6-difluoroaniline(67567-26-4)¹HNMR 4-Bromo-2,6-difluoroaniline(67567-26-4)FT-IR

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2,6-DIFLUORO-4-BROMOANILINE 4-BROMO-2,6-DIFLUOROANILINE 4-BROMO-2,6-DIFLUOROANILINE 99% BUTTPARK 22\07-66 4-Bromo-2,6-difluoroaniline ,98% 4-Bromo-2,6-difluoro 2,6-difluro-4-broMoaniline (4-BroMo-2,6-difluorophenyl)aMine BenzenaMine,4-broMo-2,6-difluoro- 4-Bromo-2,6-diflaoroaniline 4-Bromo-2, 6-difluoroan BFQSQUAVMNHOEF-UHFFFAOYSA-N 4-Bromo-2,6-difluoroaniline > 4-Bromo-2,6-difluoroaniline ISO 9001：2015 REACH best offer 4-Bromo-2,6-difluoroaniline 67567-26-4 4-Bromo-2,6-difluoroaniline best price factory Vandetanib Impurity 8 Abesili impurity 10 4-Bromo-2,6-difluoroaniline, 95% 67567-26-4 BrC6H2F2NH2 C6H4BrF2N Building Blocks Amines C2 to C6 Organic Building Blocks Nitrogen Compounds Anilines, Aromatic Amines and Nitro Compounds Anilines, Amides & Amines Bromine Compounds Fluorine Compounds Amines C2 to C6 Nitrogen Compounds