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Cefozopran

Cefozopran structure

CAS No.: 113359-04-9

Chemical Name:: Cefozopran

Synonyms: D01052;Firstci;sce2787;SCE-1787;Firstcin);CEFOZOPRAN;Cefozopran (inn);SCE2787;SCE 2787;SCE-2787：Fastocin;Cefozopran(SCE 2787)

CBNumber:: CB2198495

Molecular Formula:: C19H17N9O5S2

Molecular Weight:: 515.53

MDL Number:: MFCD00883679

MOL File:: 113359-04-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:00:00

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Cefozopran Properties

Melting point	>300°C
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	2.256±0.50(predicted)
InChIKey	QDUIJCOKQCCXQY-RWDKEWRNNA-N
SMILES	C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3N=C(N)SN=3)=N\OC)C(=O)N12)C[N+]1C=CN2N=CC=CC=12)(=O)[O-] \|&1:5,7,r\|
CAS DataBase Reference	113359-04-9(CAS DataBase Reference)
FDA UNII	1LG87K28LW
ATC code	J01DE03

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H334-H317
Precautionary statements	P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501

Cefozopran price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Crysdot	CD31004510	Cefozopran 98+%	113359-04-9	50mg	$122	2026-05-27	Buy
Crysdot	CD31004510	Cefozopran 98+%	113359-04-9	100mg	$184	2026-05-27	Buy
AHH	MT-49084	Cefozopran 97%		0.5g	$910	2026-05-26	Buy
DC Chemicals	DC8067	Cefozopran >98%	113359-04-9	100mg	$550	2026-05-24	Buy
DC Chemicals	DC8067	Cefozopran >98%	113359-04-9	250mg	$1000	2026-05-24	Buy

Product number	Packaging	Price	Buy
CD31004510	50mg	$122	Buy
CD31004510	100mg	$184	Buy
MT-49084	0.5g	$910	Buy
DC8067	100mg	$550	Buy
DC8067	250mg	$1000	Buy

Cefozopran Chemical Properties, Uses, Production

Chemical Properties

White To Pale-Yellow Powder

Uses

Antibacterial

Definition

ChEBI: Cefozopran is a fourth-generation cephalosporin antibiotic having imidazo[1,2-b]pyridazin-1-ium-1-ylmethyl and [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups located at positions 3 and 7 respectively. It is a cephalosporin, a member of thiadiazoles and an imidazopyridazine.

Antimicrobial activity

An aminothiazole cephalosporin formulated as the hydrochloride. Activity is similar to that of ceftazidime, but it is more active against methicillin-susceptible staphylococci (MIC 1 mg/L). Representative MICs against Gram-negative species are: Esch coli 0.25 mg/L; K. pneumoniae 1 mg/L; Ps. aeruginosa 1–8 mg/L. Activity against Acinetobacter spp., Sten. maltophilia and B. fragilis group is poor.
A 20-min infusion of 1.5 g achieved a plasma concentration of around 125 mg/L at the end of infusion. Almost 90% of the dose was excreted in the urine over 24 h. The mean terminal half-life was around 2 h. Adverse reactions appear to be typical of those of other group 6 cephalosporins.
It is available in Japan.

in vivo

Cefozopran (SCE-2787) (5-80 mg/kg; s.c.; twice a day for 5 days; four-week-old ICR male mice) is effective against acute respiratory tract infections caused by Kiebsiella pneumonia DT-S. In the model of chronic respiratory tract infection caused by K. pneumoniae 27, Cefozopran (20-80 mg/kg; s.c.; twice a day for 7 days; five-week-old CBA/J female mice) is as effective as Ceftazidime^[2].

IC 50

β-lactam

Cefozopran Preparation Products And Raw materials

Raw materials

2-Mercapto-5-methyl-1,3,4-thiadiazole Hexane Potassium iodide 2-Butanone Trifluoroacetic acid

Pyridazine Phosphorus pentachloride Ethyl acetate Dichloromethane Formamide

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Preparation Products

Cefozopran Suppliers

Global Suppliers ( 118)

Supplier	Tel	Email	Country	ProdList	Advantage
Taizhou Nanfeng Pharmaceutical Research Institute	nanfengpharma@126.co 18616377689	nanfengpharma@126.com	China	20008	58
Shanghai Boyle Chemical Co., Ltd.	021-50182298 021-50180596	sales@boylechem.com	China	2202	55
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12323	58
Shanghai T&W Pharmaceutical Co., Ltd.	+86 21 61551611		China	9874	58
China Kouting Group Limited	+86 (21) 5811-6473 5811-6475	sales@koutingchina.com	China	494	60
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4853	58
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2774	58
Beijing Universal Century Technology Co., Ltd.		hysj_bj.com	China	3576	55
HBCChem, Inc.	+1-510-219-6317	sales@hbcchem.com	United States	10628	60
Chengdu HuaXia Chemical Reagent Co. Ltd	400-1166-196 13458535857	cdhxsj@163.com	China	13323	58

Supplier	Advantage
Taizhou Nanfeng Pharmaceutical Research Institute	58
Shanghai Boyle Chemical Co., Ltd.	55
Beijing HuaMeiHuLiBiological Chemical	58
Shanghai T&W Pharmaceutical Co., Ltd.	58
China Kouting Group Limited	60
MedChemexpress LLC	58
AdooQ BioScience, LLC	58
Beijing Universal Century Technology Co., Ltd.	55
HBCChem, Inc.	60
Chengdu HuaXia Chemical Reagent Co. Ltd	58

113359-04-9 (Cefozopran) Related Search:

2-Mercapto-5-methyl-1,3,4-thiadiazole Acetaminophen 2,1,3-Benzothiadiazole Acetyl chloride Cefazolin

6-Aminocaproic acid Thioacetamide Acetyl coenzyme A sodium salt Acetamide Acetylacetone

Tris(hydroxymethyl)aminomethane N-Acetyl-L-cysteine Glycine N,N-Dimethylacetamide Aminoethoxyvinyl glycine hydrochloride

Diacetamide Cefotetan Cefquinome

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CEFOZOPRAN sce2787 SCE2787;SCE 2787 Cefozopran(SCE 2787) 1-[[(6R,7R)-7-[[(2Z)-(5-Amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-imidazo[1,2-b]pyridazinium hydroxide inner salt 1-[[(6R,7R)-7-[[2Z)-(5-Amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]imidazo[1,2-b]pyridazinium Inner Salt Firstci SCE-1787 Cefozopran (inn) D01052 Firstcin) SCE-2787：Fastocin (6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetyl]amino]-3-(imidazo[2,3-f]pyridazin-4-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Parent nucleus of Cefozopran Cefozopran USP/EP/BP CefozopranHydrochlorideandIntermediates (-)-1-[[(6R,7R)-7-[2-(5-Amino-1,2,4-thiadiazol-3-yl)glyoxylamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1H-imidazo[1,2-b]pyridazin-4-iumhydroxideinnersalt,7(2)-(Z)-(O-methyloxime)<-fgf->(-)-7beta-[(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetamido]-3-(1-imidazo[1,2-b]pyridazinio)methyl-3-cephem-4-carboxylate<-fgf->[6R-[6alpha,7beta(Z)]-1-[[7-[[(5-Amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]imidazo[1,2-b]pyridaziniumhydroxideinnersalt 113359-04-9 C19H17N9O5S2 C19H18ClN9O5S2 Antibacterial Intermediates & Fine Chemicals Pharmaceuticals Cefozopran Hydrochloride and its intermediates