Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
- CAS No.
- 178306-52-0
- Chemical Name:
- Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
- Synonyms
- (S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid;(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid;ALST-3;S-2-Hydroxy-3-methoxy-3;3-diphenylpropanoic acid;AMbrisentan InterMediate;Ambrisentan Hydroxy Impurity;Ambrisentan Related compound A;Ambrisentan Hydroxy Acid Impurity;Ambrisentan Hydroxy Acid Impurity (S-Isomer)
- CBNumber:
- CB22077327
- Molecular Formula:
- C16H16O4
- Molecular Weight:
- 272.3
- MDL Number:
- MFCD11113284
- MOL File:
- 178306-52-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 121 °C |
|---|---|
| Boiling point | 430.3±45.0 °C(Predicted) |
| Density | 1.248 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Ethanol (Sparingly, Sonicated), Methanol (Slightly) |
| pka | 3.24±0.28(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1/C16H16O4/c1-20-16(14(17)15(18)19,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11,14,17H,1H3,(H,18,19)/t14-/s3 |
| InChIKey | RQJWOLFMWKZKCJ-WDHUHKLTNA-N |
| SMILES | C(OC)(C1=CC=CC=C1)(C1C=CC=CC=1)[C@H](O)C(=O)O |&1:15,r| |
| FDA UNII | BYC8HKB4JS |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H315 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| HS Code | 2918.99.4700 | |||||||||
| NFPA 704 |
|
Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | H1568 | (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid >98.0%(HPLC)(T) | 178306-52-0 | 1g | $133 | 2026-04-30 | Buy |
| TCI Chemical | H1568 | (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid >98.0%(HPLC)(T) | 178306-52-0 | 5g | $399 | 2026-04-30 | Buy |
| Usbiological | 279674 | S-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid Asreported | 178306-52-0 | 10mg | $352 | 2026-06-03 | Buy |
| Usbiological | 279674 | S-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid Asreported | 178306-52-0 | 25mg | $505 | 2026-06-03 | Buy |
| Usbiological | 279674 | S-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid Asreported | 178306-52-0 | 50mg | $686 | 2026-06-03 | Buy |
Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- Chemical Properties, Uses, Production
Uses
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid is used in analytical studies for chiral discrimination of α-functionalized acids. Ambrisentan Hydroxy Acid Impurity.
Chemical Properties
White powder
Uses
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid is used in analytical studies for chiral discrimination of α-functionalized acids. Ambrisentan Hydroxy Acid Impurity
Synthesis
178306-51-9
178306-52-0
The general procedure for the synthesis of (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid from 2-hydroxy-3-methoxy-3,3-diphenylpropionic acid was as follows: 500 mg (1.84 mmol) of (RS)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid was dissolved in 8 mL of 2-propanol, followed by addition of 135 mg (0.92 mmol) of (S)-(+)-1,2,3,4-tetrahydro-1-naphthylamine. The reaction mixture was stirred under heated reflux conditions for 1 hour, then cooled to room temperature and continued stirring for 2 hours. The precipitated crystals were collected by filtration, washed with 2-propanol and finally dried under reduced pressure. The same operations as in Example 1 were performed according to the solvents listed in Table 1.
References
[1] Patent: JP2017/128528, 2017, A. Location in patent: Paragraph 0005; 0041; 0042; 0045; 0046
[2] Patent: WO2012/17441, 2012, A1. Location in patent: Page/Page column 11-12
[3] Patent: CN104098462, 2017, B. Location in patent: Paragraph 0009; 0028; 0029; 0031
[4] Patent: JP5700378, 2015, B2. Location in patent: Paragraph 0071; 0072
[5] Patent: WO2013/57468, 2013, A1. Location in patent: Page/Page column 23-24
Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Cheminn Chemicals Co., Ltd. | 531-67875205 15726170169 | sales@cheminn.com | China | 60 | 60 |
| Shandong Kongfu Pharmaceutical Co | 0537-4442222 18854777456 | 871825068@qq.com | China | 15 | 58 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6740 | 52 |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 7917 | 65 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
View Latest Price from Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-09-18 | (S)- 2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid
178306-52-0
|
1KG | 98%min | 100kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2024-10-22 | Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
178306-52-9
|
$6.00 | 1g | 98%HPLC | 20tons | Career Henan Chemica Co | |
 |
2021-07-13 | Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
178306-52-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- (S)- 2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid
178306-52-0
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
178306-52-9
- $6.00
- 98%HPLC
- Career Henan Chemica Co
-
- Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
178306-52-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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