Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
- CAS No.
- 178306-52-0
- Chemical Name:
- Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
- Synonyms
- ALST-3;S-2-Hydroxy-3-methoxy-3;3-diphenylpropanoic acid;AMbrisentan InterMediate;Ambrisentan Hydroxy Impurity;Ambrisentan Related compound A;Ambrisentan Hydroxy Acid Impurity;Ambrisentan Hydroxy Acid Impurity (S-Isomer);(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid;(S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid
- CBNumber:
- CB22077327
- Molecular Formula:
- C16H16O4
- Molecular Weight:
- 272.3
- MDL Number:
- MFCD11113284
- MOL File:
- 178306-52-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid >98.0%(HPLC)(T) | H1568 | 1g | $166 |
| (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid >98.0%(HPLC)(T) | H1568 | 5g | $499 |
| (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid | H946110 | 250mg | $600 |
| (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionicacid,98%(Assaybytitration,GC) 98%(Assaybytitration,GC) | 39523 | 5G | $1214.08 |
| (S)-2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPIONIC ACID 95.00% | CCH0000357 | 1KG | $20212.5 |
| More product size | |||
| Melting point | 121 °C |
|---|---|
| Boiling point | 430.3±45.0 °C(Predicted) |
| Density | 1.248 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Ethanol (Sparingly, Sonicated), Methanol (Slightly) |
| pka | 3.24±0.28(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1/C16H16O4/c1-20-16(14(17)15(18)19,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11,14,17H,1H3,(H,18,19)/t14-/s3 |
| InChIKey | RQJWOLFMWKZKCJ-WDHUHKLTNA-N |
| SMILES | C(OC)(C1=CC=CC=C1)(C1C=CC=CC=1)[C@H](O)C(=O)O |&1:15,r| |
| FDA UNII | BYC8HKB4JS |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H315 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| HS Code | 2918.99.4700 | |||||||||
| NFPA 704 |
|
Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | H1568 | (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid >98.0%(HPLC)(T) | 178306-52-0 | 1g | $166 | 2025-07-31 | Buy |
| TCI Chemical | H1568 | (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid >98.0%(HPLC)(T) | 178306-52-0 | 5g | $499 | 2025-07-31 | Buy |
| TRC | H946110 | (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid | 178306-52-0 | 250mg | $600 | 2021-12-16 | Buy |
| Chem-Impex | 39523 | (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionicacid,98%(Assaybytitration,GC) 98%(Assaybytitration,GC) | 178306-52-0 | 5G | $1214.08 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0000357 | (S)-2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPIONIC ACID 95.00% | 178306-52-0 | 1KG | $20212.5 | 2021-12-16 | Buy |
Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- Chemical Properties,Uses,Production
Uses
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid is used in analytical studies for chiral discrimination of α-functionalized acids. Ambrisentan Hydroxy Acid Impurity.
Chemical Properties
White powder
Uses
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid is used in analytical studies for chiral discrimination of α-functionalized acids. Ambrisentan Hydroxy Acid Impurity
Synthesis
178306-51-9
178306-52-0
The general procedure for the synthesis of (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid from 2-hydroxy-3-methoxy-3,3-diphenylpropionic acid was as follows: 500 mg (1.84 mmol) of (RS)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid was dissolved in 8 mL of 2-propanol, followed by addition of 135 mg (0.92 mmol) of (S)-(+)-1,2,3,4-tetrahydro-1-naphthylamine. The reaction mixture was stirred under heated reflux conditions for 1 hour, then cooled to room temperature and continued stirring for 2 hours. The precipitated crystals were collected by filtration, washed with 2-propanol and finally dried under reduced pressure. The same operations as in Example 1 were performed according to the solvents listed in Table 1.
References
[1] Patent: JP2017/128528, 2017, A. Location in patent: Paragraph 0005; 0041; 0042; 0045; 0046
[2] Patent: WO2012/17441, 2012, A1. Location in patent: Page/Page column 11-12
[3] Patent: CN104098462, 2017, B. Location in patent: Paragraph 0009; 0028; 0029; 0031
[4] Patent: JP5700378, 2015, B2. Location in patent: Paragraph 0071; 0072
[5] Patent: WO2013/57468, 2013, A1. Location in patent: Page/Page column 23-24
Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8826 | 58 |
| Chengdu Aslee Biopharmaceuticals, Inc. | 28-85305008 | CHINA | 964 | 58 | |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15142 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 +86-13986145403; | info@fortunachem.com | China | 5995 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9234 | 58 |
View Lastest Price from Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-15 | (S)- 2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid
178306-52-0
|
US $0.00 / KG | 1KG | 98%min | 100kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-10-22 | Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
178306-52-9
|
US $6.00 / KG | 1g | 98%HPLC | 20tons | Career Henan Chemica Co | |
 |
2021-07-13 | Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
178306-52-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- (S)- 2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid
178306-52-0
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
178306-52-9
- US $6.00 / KG
- 98%HPLC
- Career Henan Chemica Co
-
- Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
178306-52-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
178306-52-0(Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-)Related Search:
1of4
