(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester
- CAS No.
- 494769-44-7
- Chemical Name:
- (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester
- Synonyms
- (2-N-BOC-AMINO-THIAZOL-4-YL)-METHANOL;N-Boc-2-amino-(4-hydroxymethyl)thiazole;tert-butyl 4-(hydroxymethyl)thiazol-2-ylcarbamate;tert-butyl 4-(hydroxymethyl)-1,3-thiazol-2-ylcarbamate;(4-HYDROXYMETHYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER;(4-HYDROXYMETHYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER, 95+%;Carbamic acid, N-[4-(hydroxymethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester
- CBNumber:
- CB2221212
- Molecular Formula:
- C9H14N2O3S
- Molecular Weight:
- 230.28
- MDL Number:
- MFCD08275703
- MOL File:
- 494769-44-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H332 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501 |
| HazardClass | IRRITANT |
(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 21204 | (2-N-BOC-AMINO-THIAZOL-4-YL)-METHANOL 97% | 494769-44-7 | 1G | $59 | 2026-04-30 | Buy |
| AstaTech | 21204 | (2-N-BOC-AMINO-THIAZOL-4-YL)-METHANOL 97% | 494769-44-7 | 5G | $198 | 2026-04-30 | Buy |
| Synthonix | B50417 | tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate 98% | 494769-44-7 | 250mg | $21 | 2026-05-06 | Buy |
| Synthonix | B50417 | tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate 98% | 494769-44-7 | 1g | $27 | 2026-05-06 | Buy |
| Synthonix | B50417 | tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate 98% | 494769-44-7 | 5g | $100 | 2026-05-06 | Buy |
(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester Chemical Properties, Uses, Production
Synthesis
930303-58-5
494769-44-7
Step 2: Synthesis of tert-butyl (4-hydroxymethylthiazol-2-yl)carbamate Ethyl 2-(bis(tert-butoxycarbonyl)amino)thiazole-4-carboxylate (8.0 g, 21.5 mmol) was dissolved in 160 mL of tetrahydrofuran (THF), and cooled to -15 °C. Under stirring, lithium aluminum hydride (1 M in THF, 23.5 mL, 23.6 mmol) was added slowly and dropwise, keeping the reaction temperature at -15 °C. The reaction mixture was continued to be stirred at -15 °C for 1 hour. Upon completion of the reaction, the reaction was quenched by careful addition of water and subsequently washed with saturated aqueous D-tartaric acid potassium solution. The mixture was extracted three times with ethyl acetate and the organic layers were combined. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by fast column chromatography on silica gel with ethyl acetate/heptane as eluent (5:95→50:50 gradient). The target product (4-hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester was obtained as a light yellow solid (3.2 g, 77% yield), mass spectrum (MS): m/e = 231.2 ([M+H]+).
References
[1] Patent: US2007/78155, 2007, A1. Location in patent: Page/Page column 32
(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Scientia Pharmaceutical Technology Co., Ltd. | 21-21-54301573 13917723525 | sales@scientiapharm.com | China | 260 | 62 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Witofly Chemical Co.,Ltd | sales@witofly.com | China | 2853 | 52 | |
| Yancheng Orgunion Pharmaceutical Sci & Tech Co., Ltd. | 0515-89701588 13770166955 | orgunion@orgunion.com | China | 620 | 55 |
View Latest Price from (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Tert-butyl 4-(hydroxymethyl)thiazol-2-ylcarbamate
494769-44-7
|
1KG | 98% | 20Tons | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-09-02 | (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester
494769-44-7
|
$7.00 | 1KG | 99% | Career Henan Chemical Co |
-
- Tert-butyl 4-(hydroxymethyl)thiazol-2-ylcarbamate
494769-44-7
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester
494769-44-7
- $7.00
- 99%
- Career Henan Chemical Co
