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ChemicalBook >> CAS DataBase List >>2-Chloro-5-nitronicotinic acid methyl ester

2-Chloro-5-nitronicotinic acid methyl ester

2-Chloro-5-nitronicotinic acid methyl ester Structure
2-Chloro-5-nitronicotinic acid methyl ester structure
CAS No.
190271-88-6
Chemical Name:
2-Chloro-5-nitronicotinic acid methyl ester
Synonyms
METHYL 2-CHLORO-5-NITRONICOTINATE;Methyl 2-chloro-5-nitrosoniacinate;Methyl 2-chloro-5-nitronicotinate 95+%;2-Chloro-5-nitronicotinic acid methyl ester;Methyl 2-chloro-5-nitropyridine-3-carboxylate;3-Pyridinecarboxylic acid, 2-chloro-5-nitro-, methyl ester;Methyl 2-chloro-5-nitropyridine-3-carboxylate, 2-Chloro-3-(methoxycarbonyl)-5-nitropyridine
CBNumber:
CB2232267
Molecular Formula:
C7H5ClN2O4
Molecular Weight:
216.58
MDL Number:
MFCD07368888
MOL File:
190271-88-6.mol
MSDS File:
SDS
Last updated:2026-09-12 18:50:31
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2-Chloro-5-nitronicotinic acid methyl ester Properties

Boiling point 321.5±37.0 °C(Predicted)
Density 1.500±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -5.76±0.10(Predicted)
Appearance Off-white to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P260-P280-P271
HazardClass  IRRITANT
HS Code  2933399990

2-Chloro-5-nitronicotinic acid methyl ester price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AstaTech 64197 METHYL 2-CHLORO-5-NITRONICOTINATE 97% 190271-88-6 1G $22 2026-04-30 Buy
AstaTech 64197 METHYL 2-CHLORO-5-NITRONICOTINATE 97% 190271-88-6 5G $79 2026-04-30 Buy
AstaTech 64197 METHYL 2-CHLORO-5-NITRONICOTINATE 97% 190271-88-6 25G $293 2026-04-30 Buy
Synthonix M36701 Methyl 2-chloro-5-nitronicotinate 190271-88-6 100mg $24 2026-05-06 Buy
Synthonix M36701 Methyl 2-chloro-5-nitronicotinate 190271-88-6 250mg $28 2026-05-06 Buy
Product number Packaging Price Buy
64197 1G $22 Buy
64197 5G $79 Buy
64197 25G $293 Buy
M36701 100mg $24 Buy
M36701 250mg $28 Buy

2-Chloro-5-nitronicotinic acid methyl ester Chemical Properties, Uses, Production

Synthesis

Methyl 2-hydroxy-5-nitronicotinate

89910-50-9

2-CHLORO-5-NITRONICOTINIC ACID METHYL ESTER

190271-88-6

To a 25 mL suspension of thionyl chloride of methyl nitrosyl-2-hydroxynicotinate (4.62 g, 23.3 mmol) was added 1 mL of DMF and the reaction mixture was heated to reflux until the reaction was complete as detected by TLC. Subsequently, thionyl chloride was removed by evaporation under reduced pressure and azeotroped twice with toluene to remove residual thionyl chloride. The yellow semi-solid product obtained was cooled in an ice bath and treated with 50 mL of methanol. After stirring for 20 minutes, the mixture was poured into 200 mL of water and extracted with ethyl acetate (2 x 150 mL). The organic phases were combined and washed sequentially with dilute aqueous sodium hydroxide, water and brine, then dried with magnesium sulfate. 5.03 g (99% yield) of methyl 2-chloro-5-nitronicotinate was finally obtained as a yellow oil. Its 1H NMR (400 MHz, deuterated chloroform) data were as follows: δ 4.04 (s, 3H), 8.94 (d, J = 2.78 Hz, 1H), 9.33 (d, J = 2.78 Hz, 1H).

References

[1] Patent: US2005/203081, 2005, A1. Location in patent: Page/Page column 9; 26

2-Chloro-5-nitronicotinic acid methyl ester Preparation Products And Raw materials

Raw materials

Methanol Methyl 2-hydroxy-5-nitronicotinate Thionyl chloride N,N-Dimethylformamide

Preparation Products

2-Chloro-5-nitronicotinic acid methyl ester Suppliers

Global Suppliers ( 101)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Tianjin heowns Biochemical Technology Co., Ltd. 400 638 7771 sales@heowns.com China 14412 57
Chiba Pharmaceutical Science and technology Co, Ltd. 0531-81313138 13066006660 chibapharm@foxmail.com China 3996 55
Shanghai Hong-chuang Pharma Tech Co., Ltd. 18151128828 hc-sales@foxmail.com China 2635 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Suzhou Laing Biological Technology Co., LTD 0512-62968256 18550502935 export@laingbiotec.com China 994 58
Shanghai YuLue Chemical Co., Ltd. 021-60345187 13671753212 lzz841106@aliyun.com China 10244 55
Jinan LuoHe PharmaTech Co., Ltd. 86-0531-68658065 15726150375 1071018499@qq.com China 525 58
Shanghai Song Yuan Chemical Technology Co., Ltd. 010-1234567 18521000990 sonyuanchemical@163.com China 6467 50
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Capot Chemical Co., Ltd 66
Tianjin heowns Biochemical Technology Co., Ltd. 57
Chiba Pharmaceutical Science and technology Co, Ltd. 55
Shanghai Hong-chuang Pharma Tech Co., Ltd. 55
Bide Pharmatech Ltd. 60
Suzhou Laing Biological Technology Co., LTD 58
Shanghai YuLue Chemical Co., Ltd. 55
Jinan LuoHe PharmaTech Co., Ltd. 58
Shanghai Song Yuan Chemical Technology Co., Ltd. 50

View Latest Price from 2-Chloro-5-nitronicotinic acid methyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-5-nitronicotinic acid methyl ester pictures 2026-08-25 2-Chloro-5-nitronicotinic acid methyl ester
190271-88-6
 $1.10-9.90 1KG 99% min 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2-CHLORO-5-NITRONICOTINIC ACID METHYL ESTER pictures 2020-01-10 2-CHLORO-5-NITRONICOTINIC ACID METHYL ESTER
190271-88-6
 $1.00 1g 98% 200kgs Career Henan Chemical Co

2-Chloro-5-nitronicotinic acid methyl ester Spectrum

2-CHLORO-5-NITRONICOTINIC ACID METHYL ESTER(190271-88-6)1HNMR

190271-88-6 (2-Chloro-5-nitronicotinic acid methyl ester) Related Search:

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2-Chloro-3-methyl-5-nitropyridine 2-Chloro-5-nitronicotinic acid 5-AMINO-NICOTINIC ACID METHYL ESTER

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Methyl 2-chloro-5-nitronicotinate 95+% Methyl 2-chloro-5-nitropyridine-3-carboxylate Methyl 2-chloro-5-nitropyridine-3-carboxylate, 2-Chloro-3-(methoxycarbonyl)-5-nitropyridine 3-Pyridinecarboxylic acid, 2-chloro-5-nitro-, methyl ester Methyl 2-chloro-5-nitrosoniacinate METHYL 2-CHLORO-5-NITRONICOTINATE 2-Chloro-5-nitronicotinic acid methyl ester 190271-88-6 pyridine series Boronic Acid Pyridine