3,4-Difluorobenzonitrile
- CAS No.
- 64248-62-0
- Chemical Name:
- 3,4-Difluorobenzonitrile
- Synonyms
- 3,4-fluorobenzonitrile;3,4-Difluorobenzonit;3, 4-difluoronitrile;LABOTEST-BB LT00847816;3,4-DIFLUOROBENZONITRILE;3,4-Difluorobenznitriled;3,4-difluorobenzylnitrile;3,4- twoFluorobenzonitrile;4-CYANO-1,2-DIFLUOROBENZENE;Benzonitrile, 3,4-difluoro-
- CBNumber:
- CB2236386
- Molecular Formula:
- C7H3F2N
- Molecular Weight:
- 139.1
- MDL Number:
- MFCD00011666
- MOL File:
- 64248-62-0.mol
- MSDS File:
- SDS
| Melting point | 52-54 °C (lit.) |
|---|---|
| Boiling point | 180 °C |
| Density | 1.2490 (estimate) |
| Flash point | 157 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to lump |
| color | White to Light yellow |
| BRN | 2082224 |
| InChI | InChI=1S/C7H3F2N/c8-6-2-1-5(4-10)3-7(6)9/h1-3H |
| InChIKey | BTBFCBQZFMQBNT-UHFFFAOYSA-N |
| SMILES | C(#N)C1=CC=C(F)C(F)=C1 |
| CAS DataBase Reference | 64248-62-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) | ![]() GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,T,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36/37-36/37/39 | |||||||||
| RIDADR | UN 1325 4.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Toxic | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29269090 | |||||||||
| Storage Class | 4.1B - Flammable solid hazardous materials | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3,4-Difluorobenzonitrile price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 264334 | 3,4-Difluorobenzonitrile 98% | 64248-62-0 | 5g | $61.2 | 2026-04-30 | Buy |
| TCI Chemical | D2341 | 3,4-Difluorobenzonitrile >98.0%(GC) | 64248-62-0 | 5g | $26 | 2026-04-30 | Buy |
| TCI Chemical | D2341 | 3,4-Difluorobenzonitrile >98.0%(GC) | 64248-62-0 | 25g | $74 | 2026-04-30 | Buy |
| Strem Chemicals | 09-0076 | 3,4-Difluorobenzonitrile, min. 98% min.98% | 64248-62-0 | 25g | $40 | 2026-04-30 | Buy |
| Strem Chemicals | 09-0076 | 3,4-Difluorobenzonitrile, min. 98% min.98% | 64248-62-0 | 100g | $70 | 2026-04-30 | Buy |
3,4-Difluorobenzonitrile Chemical Properties, Uses, Production
Chemical Properties
white to light yellow crystal powder
Uses
3,4-Difluorobenzonitrile has been used in the preparation of:
- fluorophenoxy herbicides
- fluorine substituted benzyl amides
Preparation
The preparation of 3,4-Difluorobenzonitrile is as follows:To the dry reactor was added 289.6 kg (1.843 kmoles) of 3,4-difluorobenzamide and 800 kg of dichloroethane solution, 241.2 kg (2.02 kmoles) of dichlorosulfoxide and catalyst DMF I.5 And the reaction was carried out at 50 ° C for 5 hours with stirring. After the reaction was complete, the reaction solution was poured into ice water with stirring and the mixture was separated to obtain a crude product having a qualitative content of 96% of 3,4-difluorobenzonitrile 259.1 kg (1.788 kmoles) in 97% yield. The crude product was distilled to give a qualitative content of 99% of 3,4,8-difluorobenzonitrile 248.6 kg (1.77 kmoles) and a distillation yield of 99%.

Application
3,4-Difluorobenzonitrile can be used as an intermediate of medicine, pesticide and liquid crystal material.
Toxics Screening Level
The ITSL for 3,4-Difluorobenzonitrile is 0.6 μg/m3 based on annual averaging.
3,4-Difluorobenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou Huiju Chemical Co., Ltd. | 0371-55900031 18137872243 | 3927209986@qq.com | China | 9999 | 55 |
| Taizhou Jun Rui Import and Export Co., Ltd. | 0576-88808091 13958565781;18968482055 | janney.liu@groundfortune.com | China | 60 | 55 |
| jinkui(taizhou)technology co ltd | 18969655221 | 530532315@qq.com | China | 203 | 58 |
| Jinan Dexinjia Bio&Tech Co., Ltd | 0531-82375880 15098789112 | 3845379039@qq.com | China | 1457 | 58 |
| Ningbo Zhenlei Chemical Co.,ltd. | 0576-88503603 15925898989 | wlh@zhenleichem.com | China | 126 | 58 |
| Shandong Baiyang Biotechnology Co., Ltd | 0533-13505335043 13505335043 | jinqiu9966@163.com | China | 64 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
Related articles
- Synthetic Method and Nucleophilic Aromatic Substitution of 3,4-Difluorobenzonitrile
- 3,4-Difluorobenzonitrile is primarily used as a synthetic raw material for pharmaceuticals, dyes, and liquid crystal materials....
- May 4,2026
View Latest Price from 3,4-Difluorobenzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-09-17 | 3,4-difluorobenzonitrile
64248-62-0
|
$100.00-1500.00 | 1000kg | 0.98 | 100 Metric Ton/Metric Tons per Year | Wuxi High Mountain Hi-tech Development Co.,Ltd. | |
![]() |
2026-09-02 | 3,4-Difluorobenzonitrile
64248-62-0
|
$6.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
![]() |
2026-05-28 | 3,4-Difluorobenzonitrile
64248-62-0
|
$10.50 | 1KG | 99% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD |
-

- 3,4-difluorobenzonitrile
64248-62-0
- $100.00-1500.00
- 0.98
- Wuxi High Mountain Hi-tech Development Co.,Ltd.
-

- 3,4-Difluorobenzonitrile
64248-62-0
- $6.00
- 99%
- Henan Fengda Chemical Co., Ltd
-

- 3,4-Difluorobenzonitrile
64248-62-0
- $10.50
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
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