ethyl 2-chloro-4-ethoxy-nicotinate
- CAS No.
- 127423-61-4
- Chemical Name:
- ethyl 2-chloro-4-ethoxy-nicotinate
- Synonyms
- Bexagliflozin Impurity 17;ethyl 2-chloro-4-ethoxy-nicotinate;(R)-1-Boc-3-[(methylsulfonyl)oxy]pyrrolidine;(3R)-N-(tert-Butoxycarbonyl)-3-(methylsulfonyloxy)pyrrolidine;tert-Butyl (R)-3-(methylsulfonyloxy)pyrrolidine-1-carboxylate;tert-Butyl (R)-3-[(methylsulfonyl)oxy]pyrrolidine-1-carboxylate;tert-Butyl (3R)-3-[(methylsulfonyl)oxy]pyrrolidine-1-carboxylate;1,1-Dimethylethyl (3R)-3-[(methylsulfonyl)oxy]-1-pyrrolidinecarboxylate;(R)-3-[(Methylsulfonyl)oxy]pyrrolidine-1-carboxylic acid tert-butyl ester;1-Pyrrolidinecarboxylic acid, 3-[(methylsulfonyl)oxy]-, 1,1-dimethylethylester, (3R)-
- CBNumber:
- CB22598587
- Molecular Formula:
- C10H19NO5S
- Molecular Weight:
- 265.33
- MDL Number:
- MFCD06809586
- MOL File:
- 127423-61-4.mol
- MSDS File:
- SDS
ethyl 2-chloro-4-ethoxy-nicotinate price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA009BGX | (R)-tert-Butyl 3-((methylsulfonyl)oxy)pyrrolidine-1-carboxylate 95% | 127423-61-4 | 100mg | $14 | 2026-05-28 | Buy |
| aablocks | AA009BGX | (R)-tert-Butyl 3-((methylsulfonyl)oxy)pyrrolidine-1-carboxylate 95% | 127423-61-4 | 250mg | $22 | 2026-05-28 | Buy |
| aablocks | AA009BGX | (R)-tert-Butyl 3-((methylsulfonyl)oxy)pyrrolidine-1-carboxylate 98% | 127423-61-4 | 1g | $35 | 2026-05-28 | Buy |
| aablocks | AA009BGX | (R)-tert-Butyl 3-((methylsulfonyl)oxy)pyrrolidine-1-carboxylate 95% | 127423-61-4 | 5g | $54 | 2026-05-28 | Buy |
| aablocks | AA009BGX | (R)-tert-Butyl 3-((methylsulfonyl)oxy)pyrrolidine-1-carboxylate 95% | 127423-61-4 | 10g | $85 | 2026-05-28 | Buy |
ethyl 2-chloro-4-ethoxy-nicotinate Chemical Properties, Uses, Production
Synthesis
83220-73-9
124-63-0
127423-61-4
General Steps: Step 1: Synthesis of (R)-1-(tert-butoxycarbonyl)pyrrolidin-3-yl methanesulfonate. A solution of tert-butyl (R)-3-hydroxypyrrolidine-1-carboxylate (1.0 g, 5.3 mmol) and triethylamine (2.77 mL, 20 mmol) was cooled in an ice water bath in dichloromethane (20 mL). To this solution was added methosulfonyl chloride (1.15 mL, 15 mmol) diluted in dichloromethane (10 mL) dropwise. The reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, water was added and the organic phase was extracted with dichloromethane (3 x 50 mL). The combined organic phases were dried and purified by silica gel chromatography (50% ethyl acetate:hexane to 100% ethyl acetate gradient) to afford (R)-1-(tert-butoxycarbonyl)pyrrolidin-3-yl methanesulfonate (1.53 g, brown oil, 100% yield).
References
[1] Patent: WO2010/45542, 2010, A2. Location in patent: Page/Page column 73
[2] Patent: WO2012/62783, 2012, A1. Location in patent: Page/Page column 75
[3] Patent: WO2017/12576, 2017, A1. Location in patent: Page/Page column 187
[4] Patent: WO2018/71454, 2018, A1. Location in patent: Paragraph 001372; 001373; 001374
[5] Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, vol. 33, # 1, p. 1460 - 1471
ethyl 2-chloro-4-ethoxy-nicotinate Preparation Products And Raw materials
ethyl 2-chloro-4-ethoxy-nicotinate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Firster Pharmaceutical Co., Ltd. | 19138996873 | 670603485@qq.com | China | 196 | 58 |
| BTC Pharmaceutical CO. Ltd | +86-15716293042 15716293042 | info@btcpharm.com | China | 822 | 55 |
| Nantong Xiaochang Pharmaceutical Trading Co., Ltd. | 0513-82104991 18862997351 | sales11@btcpharm.com | China | 859 | 58 |
| Shanghai Hobor Chemical Co., Ltd | 13918007836 | sales@hoborchem.com | China | 434 | 60 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Chengdu Firster Pharmaceutical Co., Ltd. | 028-87078428 028-87074958 | chengzhenyong@cdfirster.com | China | 2580 | 60 |
| Shanghai AQBioPharma Co., Ltd. | 13661411401 | yinglv.que@aqbiopharma.com.cn | China | 2976 | 58 |
View Latest Price from ethyl 2-chloro-4-ethoxy-nicotinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | ethyl 2-chloro-4-ethoxy-nicotinate
127423-61-4
|
$1.00 | 1g | 99.0% | 100kg | Career Henan Chemical Co |
-
- ethyl 2-chloro-4-ethoxy-nicotinate
127423-61-4
- $1.00
- 99.0%
- Career Henan Chemical Co
