1-Boc-3-methanesulfonyloxypyrrolidine
- CAS No.
- 141699-57-2
- Chemical Name:
- 1-Boc-3-methanesulfonyloxypyrrolidine
- Synonyms
- 1-(tert-Butoxycarbonyl)pyrrolidin-3-yl methanesulfonate;138883;(R)-3-(Methylsulphonyloxy)pyrrolidine;1-Boc-3-pyrrolidinyl Methanesulfonate;1-Boc-3-methanesulfonyloxypyrrolidine;(3S)-N-Boc-3-[(methylsulphonyl)oxy]pyrrolidine;(R)-3-(Methylsulfonyloxy)pyrrolidine, N-BOC protected;(R)-3-(Methylsulphonyloxy)pyrrolidine, N-BOC protected;2-(3-pyrrolidinyloxysulfonyl)acetic acid tert-butyl ester;(R)-3-(Methylsulphonyloxy)pyrrolidine, N-BOC protected 95+%
- CBNumber:
- CB8479581
- Molecular Formula:
- C10H19NO5S
- Molecular Weight:
- 265.33
- MDL Number:
- MFCD04116219
- MOL File:
- 141699-57-2.mol
- MSDS File:
- SDS
| Boiling point | 392.9±31.0 °C(Predicted) |
|---|---|
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | solid |
| pka | -3.65±0.40(Predicted) |
| InChI | 1S/C10H19NO5S/c1-10(2,3)15-9(12)11-6-5-8(7-11)16-17(4,13)14/h8H,5-7H2,1-4H3/t8-/m1/s1 |
| InChIKey | KWQRKOSMSFLBTJ-MRVPVSSYSA-N |
| SMILES | CC(C)(C)OC(=O)N1CC[C@H](C1)OS(C)(=O)=O |
| UNSPSC Code | 12352106 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P405-P501 |
| Hazard Codes | Xi,T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 2933998090 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral |
1-Boc-3-methanesulfonyloxypyrrolidine price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ADE000053 | (R)-3-Methanesulfonyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester Aldrich | 141699-57-2 | 1g | $230 | 2026-04-30 | Buy |
| Apolloscientific | OR2890 | (R)-3-(Methylsulphonyloxy)pyrrolidine, N-BOC protected >96% | 141699-57-2 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR2890 | (R)-3-(Methylsulphonyloxy)pyrrolidine, N-BOC protected >96% | 141699-57-2 | 1g | $33 | 2026-06-04 | Buy |
| Apolloscientific | OR2890 | (R)-3-(Methylsulphonyloxy)pyrrolidine, N-BOC protected >96% | 141699-57-2 | 5g | $141 | 2026-06-04 | Buy |
| Apolloscientific | OR2890 | (R)-3-(Methylsulphonyloxy)pyrrolidine, N-BOC protected >96% | 141699-57-2 | 25g | $383 | 2026-06-04 | Buy |
1-Boc-3-methanesulfonyloxypyrrolidine Chemical Properties, Uses, Production
Synthesis
83220-73-9
124-63-0
141699-57-2
GENERAL STEPS: To a stirred solution of 1-tert-butoxycarbonyl-3-hydroxypyrrolidine (16 g, 85.4 mmol) and triethylamine (19 mL, 129 mmol) in 130 mL of dichloromethane was added slowly and dropwise to a solution of methanesulfonyl chloride (10 mL, 129 mmol) in 20 mL of dichloromethane at 0 °C. After the dropwise addition was completed, the reaction mixture was continued to be stirred at room temperature for 2.5 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium bicarbonate and extracted with dichloromethane. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give tert-butyl 3-methanesulfonyloxypyrrolidine-1-carboxylate (22.7 g, 100% yield) as a yellow solid.
References
[1] Patent: WO2013/97773, 2013, A1. Location in patent: Paragraph 0150
[2] Patent: US2016/168156, 2016, A1. Location in patent: Paragraph 0494; 0495
[3] Patent: KR2016/103390, 2016, A. Location in patent: Paragraph 0099; 0102
[4] Patent: CN107474024, 2017, A. Location in patent: Paragraph 0385; 0389; 0390; 0391
[5] Patent: US2016/200730, 2016, A1. Location in patent: Paragraph 0278; 0279
1-Boc-3-methanesulfonyloxypyrrolidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 4904 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Chengdu Firster Pharmaceutical Co., Ltd. | 028-87078428 028-87074958 | chengzhenyong@cdfirster.com | China | 2580 | 60 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
View Latest Price from 1-Boc-3-methanesulfonyloxypyrrolidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-01-27 | (R)-1-Boc-3-methanesulfonyloxypyrrolidine
141699-57-2
|
1KG | 98.3% | 100 tons | Honest Joy Holdings Limited | ||
 |
2020-02-01 | 1-BOC-3-METHANESULFONYLOXYPYRROLIDINE
141699-57-2
|
$1.00 | 1KG | 98% | 200kgs | Career Henan Chemical Co |
-
- (R)-1-Boc-3-methanesulfonyloxypyrrolidine
141699-57-2
- $0.00
- 98.3%
- Honest Joy Holdings Limited
-
- 1-BOC-3-METHANESULFONYLOXYPYRROLIDINE
141699-57-2
- $1.00
- 98%
- Career Henan Chemical Co
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