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N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol

N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol structure

CAS No.: 101469-92-5

Chemical Name:: N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol

Synonyms: tert-butyl (S)-3-hydroxypyrrolidine-1-carboxylate;(S)-1-BOC-3-HYDROXYPYRROLIDINE;(S)-TERT-BUTYL 3-HYDROXYPYRROLIDINE-1-CARBOXYLATE;(S)-N-BOC-3-PYRROLIDINOL;(S)-1-N-Boc-3-pyrrolidinol;(S)-N-BOC-3-HYDROXYPYRROLIDINE;(S)-1-Boc-3;(S)-1-BOC-3-Pyrolidinol;Cilnidipine Impurity 62;(S)-1-BOC-3-PYRROLIDINOL

CBNumber:: CB4232377

Molecular Formula:: C9H17NO3

Molecular Weight:: 187.24

MDL Number:: MFCD01317839

MOL File:: 101469-92-5.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:41

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N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol Properties

Melting point	60-64 °C (lit.)
alpha	26 º (c=1%, MeOH)
Boiling point	273.3±33.0 °C(Predicted)
Density	1.142±0.06 g/cm3(Predicted)
refractive index	27 ° (C=1, MeOH)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
pka	14.74±0.20(Predicted)
form	Crystalline Powder
color	White to pale yellow
optical activity	[α]20/D +26°, c = 1% in methanol
BRN	6271108
InChI	InChI=1S/C9H17NO3/c1-9(2,3)13-8(12)10-5-4-7(11)6-10/h7,11H,4-6H2,1-3H3/t7-/m0/s1
InChIKey	APCBTRDHCDOPNY-ZETCQYMHSA-N
SMILES	N1(C(OC(C)(C)C)=O)CC[C@H](O)C1
CAS DataBase Reference	101469-92-5(CAS DataBase Reference)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS06

Signal word

Danger

Hazard statements

H301-H315-H318-H335

Precautionary statements

P280-P301+P310+P330-P302+P352-P305+P351+P338+P310

Hazard Codes

T,Xi

Risk Statements

25-37/38-41-R41-R37/38-R25

Safety Statements

26-39-45-S45-S39-S26

RIDADR

UN 2811 6.1/PG 3

WGK Germany

HazardClass

6.1

PackingGroup

Ⅲ

HS Code

29339900

NFPA 704

	1
2		0

N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	634786	(S)-(+)-N-Boc-3-pyrrolidinol 97%	101469-92-5	1g	$27.9	2025-07-31	Buy
Sigma-Aldrich	634786	(S)-(+)-N-Boc-3-pyrrolidinol 97%	101469-92-5	5g	$90.3	2025-07-31	Buy
TCI Chemical	B3055	(S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol >98.0%(GC)	101469-92-5	1g	$31	2025-07-31	Buy
TCI Chemical	B3055	(S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol >98.0%(GC)	101469-92-5	5g	$46	2025-07-31	Buy
TRC	B809915	(S)-tert-Butyl3-hydroxypyrrolidine-1-carboxylate	101469-92-5	1g	$75	2021-12-16	Buy

Product number	Packaging	Price	Buy
634786	1g	$27.9	Buy
634786	5g	$90.3	Buy
B3055	1g	$31	Buy
B3055	5g	$46	Buy
B809915	1g	$75	Buy

N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

(S)-(+)-N-Boc-3-pyrrolidinol can be used as a reactant to synthesize:

tert-Butyl 3-(2-bromophenoxy)pyrrolidine-1-carboxylate, which is employed as a key intermediate in the preparation of IkB-kinase IKK2 inhibitor.
Dimethoxy-pyrrolidylquinazoline , and peptidomimetic quinoline derivatives.

Synthesis

24424-99-5

40499-83-0

83220-73-9

The general procedure for the synthesis of 1-tert-butoxycarbonyl-3-hydroxy-pyrrolidine from di-tert-butyl dicarbonate and 3-hydroxy-pyrrolidine was as follows: first, (R)-3-pyrrolidinol (539 mg, 6.19 mmol) was converted into compound 16b to afford a colorless oily substance (1.3 g, 100% yield). The spectral data of this product were consistent with the expected structure and in accordance with literature reports (see Kucznierz, R. et al. J. Med. Chem. 1998, 41, 4983-4994). Subsequently, compound 16b was converted by reaction to compound 16c, again as a colorless oil. Next, compound 16e was prepared from compound 16c by a two-step reaction, still as a colorless oily substance. Finally, compound 16e was further reacted to obtain the target product compound 16, which was rendered as a yellow oily substance.

References

[1] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 10, p. 969 - 973
[2] Patent: WO2015/9731, 2015, A2. Location in patent: Paragraph 00106
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 25, p. 4983 - 4994
[4] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 17, p. 5812 - 5832
[5] Patent: WO2010/84767, 2010, A1. Location in patent: Page/Page column 86

N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol Preparation Products And Raw materials

Raw materials

N-Boc-3-pyrrolidinone Di-tert-butyl dicarbonate 3-Pyrrolidinol (R)-(-)-3-Pyrrolidinol hydrochloride Triethylamine

1,4-Dioxane

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Preparation Products

ethyl 2-chloro-4-ethoxy-nicotinate (S)-1-Boc-3-methanesulfonyloxy-pyrrolidine (R)-1-Boc-3-cyanopyrrolidine (S)-tert-butyl 3-isopropoxypyrrolidine-1-carboxylate 1-Pyrrolidinecarboxylic acid, 3-(2-bromo-5-chlorophenoxy)-, 1,1-dimethylethyl ester, (3S)-

(S)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE (S)-3-Hydroxypyrrolidine hydrochloride

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N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol Suppliers

Global( 398)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +86-15064153060	sales01@jndxj.com	China	297	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1014	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Moxin Chemicals	+8617320513646	Anna@molcoo.com	China	9902	58
Chembon Pharmaceutical Co., Ltd.	+86-28-8425-2981		CHINA	722	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Shanghai Arbor Chemical Co., Ltd.	021-60451682	act@arborchemical.com	CHINA	904	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58

Supplier	Advantage
Anhui Dexinjia Biopharm Co., Ltd	58
Hangzhou ICH Biofarm Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Moxin Chemicals	58
Chembon Pharmaceutical Co., Ltd.	55
career henan chemical co	58
Shanghai Arbor Chemical Co., Ltd.	58
Jinan Carbotang Biotech Co.,Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Accela ChemBio Inc.	58

View Lastest Price from N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-07-31	Evocalcet Impurity 10 101469-92-5	US $0.00-0.00 / mg	10mg	95%+	10000	Moxin Chemicals
2025-07-08	(S)-1-N-Boc-3-pyrrolidinol 101469-92-5	US $0.00-0.00 / kg	1kg	99.0%	20 tons	Hangzhou ICH Biofarm Co., Ltd
2025-06-20	N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol 101469-92-5	US $200.00-180.00 / KG	1KG	less more than 98%	20tons	Anhui Dexinjia Biopharm Co., Ltd

Evocalcet Impurity 10
101469-92-5
US $0.00-0.00 / mg
95%+
Moxin Chemicals

(S)-1-N-Boc-3-pyrrolidinol
101469-92-5
US $0.00-0.00 / kg
99.0%
Hangzhou ICH Biofarm Co., Ltd

N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol
101469-92-5
US $200.00-180.00 / KG
less more than 98%
Anhui Dexinjia Biopharm Co., Ltd

N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol Spectrum

N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol(101469-92-5)¹HNMR N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol(101469-92-5)FT-IR

101469-92-5(N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol)Related Search:

N-Boc-cis-4-Hydroxy-L-proline (2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol (3R,4R)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate N-Boc-cis-4-Hydroxy-L-proline methyl ester

(R)-1-Boc-3-hydroxypyrrolidine 1-(tert-Butoxycarbonyl)-3-pyrrolidinol 3-Pyrrolidinol DL-3-PYRROLIDINOL (2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-(2-NAPHTHYLOXY)-2-PYRROLIDINECARBOXYLIC ACID

BOC-4-HYDROXY-L-PYRROLIDINE LACTONE BOC-(2S,3S)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID BOC-CIS-3-HYDROXY-D-PROLINE (2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-PHENOXY-2-PYRROLIDINECARBOXYLIC ACID BOC-D-HYP-OTBU

BOC-CISHYP(BZL)-OH (2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-(2-CHLORO-4-FLUOROPHENOXY)-2-PYRROLIDINECARBOXYLIC ACID (2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-(4-CHLORO-2-FLUOROPHENOXY)-2-PYRROLIDINECARBOXYLIC ACID

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BOC-(S)-3-HYDROXYPYRROLIDINE (3S)-(+)-N-BOC-3-HYDROXYPYRROLIDINE 1-PYRROLIDINECARBOXYLIC ACID, 3-HYDROXY-, 1,1-DIMETHYLETHYL ESTER, (3S)- (S)-3-Hydroxypyrrolidine, N-BOC protected (S)-(+)-1-Boc-3-hydroxypyrrolidine, 99%, ee 99% (S)-N-(tert-Butoxycarbonyl)-(+)-3-pyrrolidinol (S)-(+)-N-BOC-3-pyrrolidinol,98+% (S)-1-Boc-3-pyrrolidinol (S)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine (S)-1-Boc-3-pyrrolidinol,(S)-1-Boc-3-hydroxypyrrolidine S-1-N-Boc-3- hydroxy-pyrroline (3S)-3-Hydroxypyrrolidine, N-BOC protected (3S)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine, tert-Butyl (3S)-3-hydroxypyrrolidine-1-carboxylate tert-butyl 3-hydro×ypyrrolidine-1-carbo×ylate (S)-N-Boc-3-hydroxypyrrolidine, ee: 98% (S)-1-Boc-3-pyrrolidinol (S)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine (S)-1-Boc-3-hydroxypyrrolidine (S)-(+)-1-Boc-3-hydroxypyrrolidine (S)-1-BOC-3-Pyrolidinol (S)-1-N-Boc-3-hydroxypyrrolidine, 99%, ee: 98% (3S)-1-Boc-3-pyrrolidinol~(3S)-1-tert-Butoxycarbonyl-3-hydroxypyrrolidine (3S)-1-tert-Butoxycarbonyl-3-pyrrolidinol (S)-1-N-Boc-3-pyrrolidinol (S)-(+)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE (S)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE (S)-N-BOC-3-PYRROLIDINOL (S)-N-BOC-3-HYDROXYPYRROLIDINE HYDROCHLORIDE (S)-TERT-BUTYL 3-HYDROXYPYRROLIDINE-1-CARBOXYLATE (S)-(+)-BOC-3-PYRROLIDINOL (S)-3-HYDROXY-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (S)-1-BOC-3-PYRROLIDINOL (S)-1-N-BOC-3-HYDROXYPYRROLIDINE (S)-1-N-(T-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE (S)-1-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE (S)-(+)-1-BOC-3-HYDROXYPYRROLIDINE (S)-1-BOC-3-HYDROXYPYRROLIDINE N-BOC-(S)-3-HYDROXYPYRROLIDINE N-(TERT-BUTOXYCARBONYL)-(S)-(+)-3-PYRROLIDINOL N-T-BOC-(S)-3-HYDROXYPYRROLIDINE (S)-(+)-1-Boc-3-hydroxypyrrolidine N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol N-(TERT-BUTOXYCARBONYL)-(S)-(+)-3-PYRRO& (S)-N-BOC-3-HYDROXYPYRROLIDINE (S)-1-N-Boc-3-Hydroxypyrrolidin (3S)-1-boc-3-Pyrrolidinol (3S)-1-Tert-butoxycarbonyl-3-hydroxypyrrolidine (S)-1-N-Boc-3-Hydroxypyrrolidi (s)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine (S)-(+)-B-BOC-3-PYRROLIDINOL S-N-BOC-3-PYRROLIDINOL 98% (S)-N-Boc-3-hydroxypyrrolidine, 99%, ee: 98% N-(tert-Butoxycarbonyl)-(S)-3-hydroxypyrrolidine (3S)-Hydroxy-1-pyrrolidinecaboxylic acid-1,1-dimethylethyl ester tert-butyl (S)-3-hydroxypyrrolidine-1-carboxylate (S)-N-Boc-3-hydroxypyrroline (S)-1-Boc-3 (S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol > (S)-1-Boc-3-HydroxypyrroL (S) -1-n-tert-butyloxycarbonyl-3-hydroxypyrrolidone N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol USP/EP/BP 1-Pyrrolidinecarboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester, (3S)- (9CI, ACI)