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N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol

N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol structure

CAS No.: 101469-92-5

Chemical Name:: N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol

Synonyms: tert-butyl (S)-3-hydroxypyrrolidine-1-carboxylate;(S)-TERT-BUTYL 3-HYDROXYPYRROLIDINE-1-CARBOXYLATE;(S)-1-BOC-3-HYDROXYPYRROLIDINE;(S)-N-BOC-3-PYRROLIDINOL;(S)-1-N-Boc-3-pyrrolidinol;(S)-N-BOC-3-HYDROXYPYRROLIDINE;(S)-1-Boc-3;Evocalcet impurity 35;(S)-1-BOC-3-Pyrolidinol;Cilnidipine Impurity 62

CBNumber:: CB4232377

Molecular Formula:: C9H17NO3

Molecular Weight:: 187.24

MDL Number:: MFCD01317839

MOL File:: 101469-92-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:02:46

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N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol Properties

Melting point	60-64 °C (lit.)
alpha	26 º (c=1%, MeOH)
Boiling point	273.3±33.0 °C(Predicted)
Density	1.142±0.06 g/cm3(Predicted)
refractive index	27 ° (C=1, MeOH)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
pka	14.74±0.20(Predicted)
form	Crystalline Powder
color	White to pale yellow
optical activity	[α]20/D +26°, c = 1% in methanol
BRN	6271108
InChI	InChI=1S/C9H17NO3/c1-9(2,3)13-8(12)10-5-4-7(11)6-10/h7,11H,4-6H2,1-3H3/t7-/m0/s1
InChIKey	APCBTRDHCDOPNY-ZETCQYMHSA-N
SMILES	N1(C(OC(C)(C)C)=O)CC[C@H](O)C1
CAS DataBase Reference	101469-92-5(CAS DataBase Reference)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS06

Signal word

Danger

Hazard statements

H301-H315-H318-H335

Precautionary statements

P280-P301+P310+P330-P302+P352-P305+P351+P338+P310

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes

T,Xi

Risk Statements

25-37/38-41-R41-R37/38-R25

Safety Statements

26-39-45-S45-S39-S26

RIDADR

UN 2811 6.1/PG 3

WGK Germany

HazardClass

6.1

PackingGroup

Ⅲ

HS Code

29339900

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol price More Price(73)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	634786	(S)-(+)-N-Boc-3-pyrrolidinol 97%	101469-92-5	1g	$59.4	2026-04-30	Buy
Sigma-Aldrich	634786	(S)-(+)-N-Boc-3-pyrrolidinol 97%	101469-92-5	5g	$137	2026-04-30	Buy
TCI Chemical	B3055	(S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol >98.0%(GC)	101469-92-5	1g	$25	2026-04-30	Buy
TCI Chemical	B3055	(S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol >98.0%(GC)	101469-92-5	5g	$37	2026-04-30	Buy
Usbiological	264239	S-N-Boc-3-hydroxypyrrolidine Asreported	101469-92-5	10g	$365	2026-06-03	Buy

Product number	Packaging	Price	Buy
634786	1g	$59.4	Buy
634786	5g	$137	Buy
B3055	1g	$25	Buy
B3055	5g	$37	Buy
264239	10g	$365	Buy

N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

(S)-(+)-N-Boc-3-pyrrolidinol can be used as a reactant to synthesize:

tert-Butyl 3-(2-bromophenoxy)pyrrolidine-1-carboxylate, which is employed as a key intermediate in the preparation of IkB-kinase IKK2 inhibitor.
Dimethoxy-pyrrolidylquinazoline , and peptidomimetic quinoline derivatives.

Synthesis

24424-99-5

40499-83-0

83220-73-9

The general procedure for the synthesis of 1-tert-butoxycarbonyl-3-hydroxy-pyrrolidine from di-tert-butyl dicarbonate and 3-hydroxy-pyrrolidine was as follows: first, (R)-3-pyrrolidinol (539 mg, 6.19 mmol) was converted into compound 16b to afford a colorless oily substance (1.3 g, 100% yield). The spectral data of this product were consistent with the expected structure and in accordance with literature reports (see Kucznierz, R. et al. J. Med. Chem. 1998, 41, 4983-4994). Subsequently, compound 16b was converted by reaction to compound 16c, again as a colorless oil. Next, compound 16e was prepared from compound 16c by a two-step reaction, still as a colorless oily substance. Finally, compound 16e was further reacted to obtain the target product compound 16, which was rendered as a yellow oily substance.

References

[1] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 10, p. 969 - 973
[2] Patent: WO2015/9731, 2015, A2. Location in patent: Paragraph 00106
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 25, p. 4983 - 4994
[4] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 17, p. 5812 - 5832
[5] Patent: WO2010/84767, 2010, A1. Location in patent: Page/Page column 86

N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol Preparation Products And Raw materials

Raw materials

N-Boc-3-pyrrolidinone Di-tert-butyl dicarbonate 3-Pyrrolidinol (R)-(-)-3-Pyrrolidinol hydrochloride Triethylamine

1,4-Dioxane

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Preparation Products

ethyl 2-chloro-4-ethoxy-nicotinate (S)-1-Boc-3-methanesulfonyloxy-pyrrolidine (R)-1-Boc-3-cyanopyrrolidine (S)-tert-butyl 3-isopropoxypyrrolidine-1-carboxylate 1-Pyrrolidinecarboxylic acid, 3-(2-bromo-5-chlorophenoxy)-, 1,1-dimethylethyl ester, (3S)-

(S)-1-(tert-Butoxycarbonyl)piperidin-3-yl methanesulfonate (S)-3-Hydroxypyrrolidine hydrochloride

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N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol Suppliers

Global( 406)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuxi Hailun Bio-Technology Co., Ltd.	0510-85629785 18051595327;	sales@hlsw-bio.com	China	101	58
Sichuan Argalbio Technology Co,.Ltd	028-028-60651388 13980413900	slyu@hengkangtech.com	China	575	58
Chengdu Firster Pharmaceutical Co., Ltd.	028-87078428 028-87074958	chengzhenyong@cdfirster.com	China	2580	60
BTC Pharmaceutical CO. Ltd	+86-15716293042 15716293042	info@btcpharm.com	China	823	55
Tianjin Propharm Co., Ltd.	185-11025967 18511025967	wubin@propharm.cn	China	60	58
Nanjing Huarui Biopharmaceutical Technology Co., Ltd.	18014824111	1623163500@qq.com	China	336	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84

Supplier	Advantage
Wuxi Hailun Bio-Technology Co., Ltd.	58
Sichuan Argalbio Technology Co,.Ltd	58
Chengdu Firster Pharmaceutical Co., Ltd.	60
BTC Pharmaceutical CO. Ltd	55
Tianjin Propharm Co., Ltd.	58
Nanjing Huarui Biopharmaceutical Technology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Alfa Aesar	84

View Lastest Price from N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-08	(S)-1-N-Boc-3-pyrrolidinol 101469-92-5		1kg	99.0%	20 tons	Hangzhou ICH Biofarm Co., Ltd
2026-07-30	N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol 101469-92-5	$180.00-200.00	1KG	less more than 98%	20tons	Anhui Dexinjia Biopharm Co., Ltd
2025-12-16	Evocalcet Impurity 10 101469-92-5		10mg	95%+	10000	Moxin Chemicals

(S)-1-N-Boc-3-pyrrolidinol
101469-92-5
99.0%
Hangzhou ICH Biofarm Co., Ltd

N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol
101469-92-5
$180.00-200.00
less more than 98%
Anhui Dexinjia Biopharm Co., Ltd

Evocalcet Impurity 10
101469-92-5
95%+
Moxin Chemicals

N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol Spectrum

N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol(101469-92-5)¹HNMR N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol(101469-92-5)FT-IR

101469-92-5(N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol)Related Search:

DL-3-Pyrrolidinol 3-Pyrrolidinol 1-(tert-Butoxycarbonyl)-3-pyrrolidinol (R)-1-Boc-3-hydroxypyrrolidine N-Boc-cis-4-Hydroxy-L-proline methyl ester

N-Boc-cis-4-Hydroxy-L-proline (3R,4R)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate (2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol Boc-cis-3-hydroxy-D-proline

Boc-(2S,3S)-3-hydroxypyrrolidine-2-carboxylic acid (2S,4S)-1-(tert-Butoxycarbonyl)-4-phenoxy-2-pyrrolidinecarboxylic acid Boc-4-hydroxy-L-pyrrolidine lactone Boc-D-Hyp-OtBu (2S,4S)-1-(tert-Butoxycarbonyl)-4-(2-naphthyloxy)-2-pyrrolidinecarboxylic acid

(2S,4S)-1-(tert-Butoxycarbonyl)-4-(2-chloro-4-fluorophenoxy)-2-pyrrolidinecarboxylic acid Boc-cishyp(Bzl)-OH (2S,4S)-1-(tert-Butoxycarbonyl)-4-(4-chloro-2-fluorophenoxy)-2-pyrrolidinecarboxylic acid

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BOC-(S)-3-HYDROXYPYRROLIDINE (3S)-(+)-N-BOC-3-HYDROXYPYRROLIDINE 1-PYRROLIDINECARBOXYLIC ACID, 3-HYDROXY-, 1,1-DIMETHYLETHYL ESTER, (3S)- (S)-3-Hydroxypyrrolidine, N-BOC protected (S)-(+)-1-Boc-3-hydroxypyrrolidine, 99%, ee 99% (S)-N-(tert-Butoxycarbonyl)-(+)-3-pyrrolidinol (S)-(+)-N-BOC-3-pyrrolidinol,98+% (S)-1-Boc-3-pyrrolidinol (S)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine (S)-1-Boc-3-pyrrolidinol,(S)-1-Boc-3-hydroxypyrrolidine S-1-N-Boc-3- hydroxy-pyrroline (3S)-3-Hydroxypyrrolidine, N-BOC protected (3S)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine, tert-Butyl (3S)-3-hydroxypyrrolidine-1-carboxylate tert-butyl 3-hydro×ypyrrolidine-1-carbo×ylate (S)-N-Boc-3-hydroxypyrrolidine, ee: 98% (S)-1-Boc-3-pyrrolidinol (S)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine (S)-1-Boc-3-hydroxypyrrolidine (S)-(+)-1-Boc-3-hydroxypyrrolidine (S)-1-BOC-3-Pyrolidinol (S)-1-N-Boc-3-hydroxypyrrolidine, 99%, ee: 98% (3S)-1-Boc-3-pyrrolidinol~(3S)-1-tert-Butoxycarbonyl-3-hydroxypyrrolidine (3S)-1-tert-Butoxycarbonyl-3-pyrrolidinol (S)-1-N-Boc-3-pyrrolidinol (S)-(+)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE (S)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE (S)-N-BOC-3-PYRROLIDINOL (S)-N-BOC-3-HYDROXYPYRROLIDINE HYDROCHLORIDE (S)-(+)-BOC-3-PYRROLIDINOL (S)-3-HYDROXY-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (S)-1-BOC-3-PYRROLIDINOL (S)-1-N-BOC-3-HYDROXYPYRROLIDINE (S)-1-N-(T-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE (S)-1-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE (S)-(+)-1-BOC-3-HYDROXYPYRROLIDINE N-BOC-(S)-3-HYDROXYPYRROLIDINE N-(TERT-BUTOXYCARBONYL)-(S)-(+)-3-PYRROLIDINOL N-T-BOC-(S)-3-HYDROXYPYRROLIDINE (S)-(+)-1-Boc-3-hydroxypyrrolidine N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol N-(TERT-BUTOXYCARBONYL)-(S)-(+)-3-PYRRO& (S)-N-BOC-3-HYDROXYPYRROLIDINE (S)-1-N-Boc-3-Hydroxypyrrolidin (3S)-1-boc-3-Pyrrolidinol (3S)-1-Tert-butoxycarbonyl-3-hydroxypyrrolidine (S)-1-N-Boc-3-Hydroxypyrrolidi (s)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine (S)-(+)-B-BOC-3-PYRROLIDINOL S-N-BOC-3-PYRROLIDINOL 98% (S)-N-Boc-3-hydroxypyrrolidine, 99%, ee: 98% N-(tert-Butoxycarbonyl)-(S)-3-hydroxypyrrolidine (3S)-Hydroxy-1-pyrrolidinecaboxylic acid-1,1-dimethylethyl ester (S)-N-Boc-3-hydroxypyrroline (S)-1-Boc-3 (S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol > (S)-1-Boc-3-HydroxypyrroL (S) -1-n-tert-butyloxycarbonyl-3-hydroxypyrrolidone N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol USP/EP/BP 1-Pyrrolidinecarboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester, (3S)- (9CI, ACI) 3-hydroxy-1-Pyrrolidinecarboxylic acid 1,1-dimethylethyl ester (3S)- (9CI ACI) N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidino tert-Butyl (1S)-3-hydroxypyrrolidine-1-carboxylate