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ChemicalBook >> CAS DataBase List >>1-Naphthalenamine, 4-cyclopropyl-

1-Naphthalenamine, 4-cyclopropyl-

1-Naphthalenamine, 4-cyclopropyl- Structure
1-Naphthalenamine, 4-cyclopropyl- structure
CAS No.
878671-94-4
Chemical Name:
1-Naphthalenamine, 4-cyclopropyl-
Synonyms
4-Cyclopropylnaphthalen-1-aMine;4-cyclopropyl-1-naphthalamine;1-phthalemine, 4-cyclopropyl-;4- cyclopropyl-1-naphthylamine;4-Cyclopropyl-1-Naphthalenamine;1-amino-4-cyclopropylnaphthalene;1-Naphthalenamine, 4-cyclopropyl-;4- cyclopropyl-1-naphthylamine oxalate;4-Cyclopropyl-1-naphthalenaMine oxalate
CBNumber:
CB81465732
Molecular Formula:
C13H13N
Molecular Weight:
183.25
MDL Number:
MFCD11109543
MOL File:
878671-94-4.mol
MSDS File:
SDS
Last updated:2026-05-28 03:20:31
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1-Naphthalenamine, 4-cyclopropyl- Properties

Boiling point 361.6±21.0 °C(Predicted)
Density 1.191
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 4.62±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

1-Naphthalenamine, 4-cyclopropyl- price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Activate Scientific AS86655 4-Cyclopropyl-1-naphthalenamine HCl 97% 878671-94-4 5g $35 2026-06-04 Buy
Activate Scientific AS86655 4-Cyclopropyl-1-naphthalenamine HCl 97% 878671-94-4 25g $105 2026-06-04 Buy
Matrix Scientific 223976 4-Cyclopropylnaphthalen-1-amine 878671-94-4 1.00g $257 2026-05-18 Buy
Matrix Scientific 223976 4-Cyclopropylnaphthalen-1-amine 878671-94-4 5.00g $897 2026-05-18 Buy
aablocks AA004EB9 4-Cyclopropylnaphthalen-1-amine 98% 878671-94-4 1g $205 2026-05-28 Buy
Product number Packaging Price Buy
AS86655 5g $35 Buy
AS86655 25g $105 Buy
223976 1.00g $257 Buy
223976 5.00g $897 Buy
AA004EB9 1g $205 Buy

1-Naphthalenamine, 4-cyclopropyl- Chemical Properties, Uses, Production

Uses

4-Cyclopropyl-1-naphthylamine is an amine derivative that can be used as an intermediate in organic synthesis.

Synthesis

4-Bromo-1-naphthylamine

2298-07-9

Cyclopropylboronic acid

411235-57-9

1-Naphthalenamine, 4-cyclopropyl-

878671-94-4

Tetrakis(triphenylphosphine)palladium (0.26 g, 0.23 mmol) and potassium phosphate (1.67 g, 7.87 mmol) were added to a 50 mL round-bottomed flask under nitrogen protection using 4-bromo-1-naphthylamine (0.50 g, 2.25 mmol) and cyclopropylboronic acid (0.212 g, 2.47 mmol). A solvent mixture of dioxane and water (25:1, 26 mL) was then added, and after three nitrogen displacements, the reaction mixture was heated to reflux in a 90 °C oil bath for 6 hours. After completion of the reaction, it was cooled to room temperature and filtered to remove insoluble material. The filtrate was concentrated under reduced pressure to remove the solvent, diluted with 50 mL of water and extracted with ethyl acetate (2 x 10 mL). The organic layers were combined, washed twice with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated to give the intermediate 4-cyclopropyl-1-aminonaphthalene as a purplish red oil in 95.3% yield.

References

[1] Chemical Biology and Drug Design, 2016, vol. 88, # 2, p. 241 - 253
[2] Patent: CN105175414, 2017, B. Location in patent: Paragraph 0040
[3] Patent: CN105566237, 2016, A. Location in patent: Paragraph 0060; 0061; 0062
[4] Patent: CN106083847, 2016, A. Location in patent: Paragraph 0133; 0134; 0170; 0171
[5] Patent: WO2006/26356, 2006, A2. Location in patent: Page/Page column 35-36

1-Naphthalenamine, 4-cyclopropyl- Preparation Products And Raw materials

Raw materials

1-Cyclopropyl-4-nitronaphthalene 4-Bromo-1-naphthylamine Cyclopropylboronic acid Tetrakis(triphenylphosphine)palladium Water
1,4-Dioxane Potassium phosphate tribasic

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Preparation Products

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione RDEA-594 sodiuM Naphthalene, 1-cyclopropyl-4-isothiocyanato-

1-Naphthalenamine, 4-cyclopropyl- Suppliers

Global Suppliers ( 87)
Supplier Tel Email Country ProdList Advantage
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16306 64
Shanghai Feibo Chemical Technology Co., Ltd 021-58955608,2250286 15921236618 blinkzeng@gmail.com China 522 62
SpringPharma Tech Co.,Ltd +86-25-68710855, +86-25-68710897 sales@springpharma.net China 1260 62
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. +86-28-85122536 85324413 market@astatech.cn China 8016 55
Ningbo Taikang Chemical Co., Ltd. 0574-87365517 18074210286 sales@taikangchem.com China 294 58
Suzhou Lakestar Pharmatech Co., Ltd. 0512-63970158-603 18018108880 info@lakestarpharma.com China 401 59
Taizhou Yikang Chemical Co., Ltd. 0576-88501337 18057652630 sales@yikangchemicals.com China 272 58
Supplier Advantage
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Adamas Reagent, Ltd. 59
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Feibo Chemical Technology Co., Ltd 62
SpringPharma Tech Co.,Ltd 62
Hangzhou Sage Chemical Co., Ltd. 58
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. 55
Ningbo Taikang Chemical Co., Ltd. 58
Suzhou Lakestar Pharmatech Co., Ltd. 59
Taizhou Yikang Chemical Co., Ltd. 58

View Latest Price from 1-Naphthalenamine, 4-cyclopropyl- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4- cyclopropyl-1-naphthylamine pictures 2023-05-04 4- cyclopropyl-1-naphthylamine
878671-94-4
 $40.00-48.00 1公斤 98% 50 tons Guangzhou Sunton Biotechnology Co., Ltd.
1-Naphthalenamine, 4-cyclopropyl- pictures 2021-07-13 1-Naphthalenamine, 4-cyclopropyl-
878671-94-4
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
1-Naphthalenamine, 4-cyclopropyl- pictures 2021-07-10 1-Naphthalenamine, 4-cyclopropyl-
878671-94-4
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

878671-94-4 (1-Naphthalenamine, 4-cyclopropyl-) Related Search:

3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro 1-Naphthalenamine, 4-cyclopropyl- Naphthalene, 1-cyclopropyl-4-isothiocyanato- 4-cyclopropylnaphthalen-1-aMine hydrochloride 1-aMino-4-cyclopropylnaphthalene oxalate
tert-Butyl 4-cyclopropylnaphthalen-1-ylcarbamate

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4-Cyclopropyl-1-Naphthalenamine 1-Naphthalenamine, 4-cyclopropyl- 4-Cyclopropyl-1-naphthalenaMine oxalate 1-phthalemine, 4-cyclopropyl- 1-amino-4-cyclopropylnaphthalene 4-cyclopropyl-1-naphthalamine 4- cyclopropyl-1-naphthylamine 4- cyclopropyl-1-naphthylamine oxalate 4-Cyclopropylnaphthalen-1-aMine 878671-94-4 Lesinurad (RDEA-594)