2-Fluoro-4-iodonicotinic acid
- CAS No.
- 884494-51-3
- Chemical Name:
- 2-Fluoro-4-iodonicotinic acid
- Synonyms
- 2-Fluoro-4-iodonicotinic acid;REF DUPL: 2-fluoro-4-iodonicotinicacid;2-Fluoro-4-iodo-3-pyridinecarboxylic acid;2-fluoro-4-iodopyridine-3-carboxylic acid;2-Fluoro-4-iodopyridin-3-ylcaboxylic acid;3-Pyridinecarboxylic acid, 2-fluoro-4-iodo-;2-Fluoro-4-iodopyridine-3-carboxylic acid, 3-Carboxy-2-fluoro-4-iodopyridine
- CBNumber:
- CB2275033
- Molecular Formula:
- C6H3FINO2
- Molecular Weight:
- 267
- MDL Number:
- MFCD03095310
- MOL File:
- 884494-51-3.mol
- MSDS File:
- SDS
| Boiling point | 347.0±42.0 °C(Predicted) |
|---|---|
| Density | 2.198 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 1.20±0.10(Predicted) |
| form | solid |
| color | Off-white |
| InChI | InChI=1S/C6H3FINO2/c7-5-4(6(10)11)3(8)1-2-9-5/h1-2H,(H,10,11) |
| InChIKey | QKPLTGKHTYHYLU-UHFFFAOYSA-N |
| SMILES | C1(F)=NC=CC(I)=C1C(O)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933399990 |
2-Fluoro-4-iodonicotinic acid price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC49358 | 2-Fluoro-4-iodonicotinic acid 95% | 884494-51-3 | 1g | $21 | 2026-06-04 | Buy |
| Matrix Scientific | 073692 | 2-Fluoro-4-iodonicotinic acid | 884494-51-3 | 10.00g | $52 | 2026-05-18 | Buy |
| Matrix Scientific | 073692 | 2-Fluoro-4-iodonicotinic acid | 884494-51-3 | 25.00g | $100 | 2026-05-18 | Buy |
| Matrix Scientific | 073692 | 2-Fluoro-4-iodonicotinic acid | 884494-51-3 | 100.00g | $404 | 2026-05-18 | Buy |
| Synthonix | F41952 | 2-Fluoro-4-iodonicotinic acid 95+% | 884494-51-3 | 250mg | $13 | 2026-05-06 | Buy |
2-Fluoro-4-iodonicotinic acid Chemical Properties, Uses, Production
Synthesis
153034-82-3
884494-51-3
The general procedure for the synthesis of 2-fluoro-4-iodonicotinic acid from 2-fluoro-4-iodopyridine-3-carboxaldehyde was as follows: to a stirred solution of 2-fluoro-4-iodopyridine-3-carboxaldehyde (10.0 g, 39.8 mmol) in a solvent mixture of tert-butanol (350 mL) and water (100 mL) at room temperature was added sequentially 2-methyl-2-butene (42.1 mL, 398 mmol) and sodium chlorite (18.0 g, 199 mmol). 398 mmol), sodium phosphate monohydrate (60.5 g, 438 mmol) and sodium chlorite (18.0 g, 199 mmol). The reaction mixture was stirred continuously for 75 minutes at room temperature. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and the pH was adjusted to about 2 by slow addition of 6 M aqueous hydrochloric acid. subsequently, the aqueous layer was extracted with dichloromethane. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. Finally, the target product 2-fluoro-4-iodonicotinic acid (10.63 g, 39.8 mmol, 100% yield) was purified by medium pressure liquid chromatography (MPLC) using a gradient elution (100/0 to 80/20) of dichloromethane/methanol (containing 1% acetic acid). Mass spectrum (ESI positive ion mode) m/z: 268 ([M+H]+). exact mass calculated for C6H3FINO2 was 267.
References
[1] Patent: WO2006/116713, 2006, A1. Location in patent: Page/Page column 194-195
[2] Patent: WO2016/95204, 2016, A1. Location in patent: Page/Page column 62; 63
2-Fluoro-4-iodonicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Summedchem Co.,Ltd | 0319-5801333-8008 15630992918 | sales@summedchem.com | China | 1000 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| QINGDAO CARELONGPHARMATECH CO.,LTD | 053288191853 13061484198 | sales@carelongchem.com | China | 455 | 57 |
| Pharmsynth Pharmaceutical (Chengdu) Technology Co.,LTD | 15528092102 | Pharmsynth@hotmail.com | China | 116 | 60 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Shanghai Witofly Chemical Co.,Ltd | sales@witofly.com | China | 2853 | 52 |
View Latest Price from 2-Fluoro-4-iodonicotinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-03-08 | 2-FLUORO-4-IODONICOTINIC ACID
884494-51-3
|
$3.00 | 1KG | 99%min | 500kg | Career Henan Chemical Co |
-
- 2-FLUORO-4-IODONICOTINIC ACID
884494-51-3
- $3.00
- 99%min
- Career Henan Chemical Co
