Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2'-O-Methylguanosine

2'-O-Methylguanosine

2'-O-Methylguanosine Structure
2'-O-Methylguanosine structure
CAS No.
2140-71-8
Chemical Name:
2'-O-Methylguanosine
Synonyms
2'-OMe-G;OMe-rG;2'-OMe-rG;2'-OMe-Gr;2'-OMe Guanosine;2′,-O-Me-Guo;2'-O-Methylguanosine;2'-O-Methylguanosine;2 '- Methoxyguanosine;2'- 0 -Methylguanosine
CBNumber:
CB2276641
Molecular Formula:
C11H15N5O5
Molecular Weight:
297.27
MDL Number:
MFCD00057053
MOL File:
2140-71-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:04:49
Request For Quotation

2'-O-Methylguanosine Properties

Melting point 227-231°C (dec.)
Density 1.98±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Aqueous Base (Slightly), DMSO (Slightly),
form Powder
pka 9+-.0.20(Predicted)
color White to Off-white
λmax 256 (pH 1)；258 (pH 11)
InChI InChI=1S/C11H15N5O5/c1-20-7-6(18)4(2-17)21-10(7)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1
InChIKey OVYNGSFVYRPRCG-KQYNXXCUSA-N
SMILES OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](OC)[C@@H]1O
CAS DataBase Reference 2140-71-8(CAS DataBase Reference)
FDA UNII W722H4PA1S

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38-22
Safety Statements  26-36-60-36/37
HS Code  29349990
NFPA 704
0
2 0

2'-O-Methylguanosine price More Price(59)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical M2318 2'-O-Methylguanosine Hydrate >98.0%(HPLC)(T) 2140-71-8 1g $202 2026-04-30 Buy
TCI Chemical M2318 2'-O-Methylguanosine Hydrate >98.0%(HPLC)(T) 2140-71-8 200mg $64 2026-04-30 Buy
Cayman Chemical 21039 2''-O-Methylguanosine ≥98% 2140-71-8 250mg $63 2026-04-30 Buy
Cayman Chemical 21039 2''-O-Methylguanosine ≥98% 2140-71-8 500mg $103 2026-04-30 Buy
Cayman Chemical 21039 2''-O-Methylguanosine ≥98% 2140-71-8 1g $169 2026-04-30 Buy
Product number Packaging Price Buy
M2318 1g $202 Buy
M2318 200mg $64 Buy
21039 250mg $63 Buy
21039 500mg $103 Buy
21039 1g $169 Buy

2'-O-Methylguanosine Chemical Properties,Uses,Production

Description

2'-O-Methylguanosine is a nucleoside that contains a 2'-O-methyl group at the 2' position of the ribose. It is a component of many nucleic acids and is usually found as a minor component in RNA. 2'-O-Methylguanosine has been shown to be an inhibitor of DNA polymerase and an activator of RNA polymerase, which may be due to its ability to form hydrogen bonds with the phosphate backbone.

Chemical Properties

White Solid

Uses

Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.

Definition

ChEBI: Guanosine with the hydrogen on the hydroxyl at position C-2' substituted with a methyl group.

Synthesis

8-Thio-2'-O-methylguanosine (1 mmole) is dissolved in water and the solution is heated at reflux with Raney nickel for 6 h. The product is isolated by passing the solution through a short pad of celite and is further crystallizing to afford 2'-O-methylguanosine.
2'-O-Methylguanosine

Physiological effects

2'-O-Methylguanosine is a modified nucleoside, it is thought to stabilize the structure of the tRNA.2'-O-Methylguanosine can also be found in rRNA. Normal and modified nucleosides, including 2'-O-methylguanosine, have been shown to be secreted by a natural suppressor cell line and induce apoptosis in K562/Molt4 target cells.

References

[1] B C PERSSON  C G  G Jger. The spoU gene of Escherichia coli, the fourth gene of the spoT operon, is essential for tRNA (Gm18) 2’-O-methyltransferase activity.[J]. Nucleic Acids Research, 1997, 25 20: 4093-4097. DOI: 10.1093/nar/25.20.4093
[2] RYOTA YAMAGAMI. Folate-/FAD-dependent tRNA methyltransferase from Thermus thermophilus regulates other modifications in tRNA at low temperatures[J]. Genes to Cells, 2016, 21 7: 740-754. DOI: 10.1111/gtc.12376
[3] JAUNIUS URBONAVICIUS  Glenn R B  Jérme M B Durand. Three modifications in the D and T arms of tRNA influence translation in Escherichia coli and expression of virulence genes in Shigella flexneri.[J]. Journal of Bacteriology, 2002, 184 19: 5348-5357. DOI: 10.1128/jb.184.19.5348-5357.2002
[4] MIROSAWA Z. BARCISZEWSKA  Jan B  Tamara D Mashkova. The primary structure of lupin seed 5.8 S ribosomal RNA[J]. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1990, 1049 3: Pages 343-345. DOI: 10.1016/0167-4781(90)90108-e
[5] K SIRUM-CONNOLLY  T L M. The role of nucleotide modifications in the yeast mitochondrial ribosome.[J]. Nucleic acids symposium series, 1995, 33: 73-75.
[6] TSUNEATSU MORI . Isolation and Identification of Apoptosis Inducing Nucleosides from CD57+HLA-DRbrightNatural Suppressor Cell Line[J]. Biochemical and biophysical research communications, 1998, 251 2: Pages 416-422. DOI: 10.1006/bbrc.1998.9423

2'-O-Methylguanosine synthesis

280-57-9
194034-59-8
2140-71-8
Synthesis of 2'-O-Methylguanosine from Triethylenediamine and 2-AMino-6-chloropurine-9-(2'-O-Methyl)riboside

2'-O-Methylguanosine Preparation Products And Raw materials

Raw materials

Preparation Products

2'-O-Methylguanosine Suppliers

Global( 291)Suppliers
Supplier Tel Email Country ProdList Advantage
HeFei ShenShen Medical Technology Co.,Ltd 15375050680; 15375050680 gdz2.71828@163.com China 31 58
Jiangsu Synthgene Biotechnology Co.,Ltd. 15852554546 starre@syngenebio.com China 901 58
Aikon International Limited 025-66113011 19370895928 qzhang@aikonchem.com China 15390 58
Wuhu Huaren Science and Technology Co., Ltd. 5842013 18155347026 xujuan@hdpharm.com China 255 64
Allbiosyn Biotechnology Co.,LTD +86-18666985712; 18666985712 info@allbiosyn.com China 298 58
AMITT Biotechnology Co., Ltd. 19157858790 19157858790 chen@amittbio.com China 560 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Hongene Biotech Corporation 021-64757213 info@hongene.com China 672 61
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Supplier Advantage
HeFei ShenShen Medical Technology Co.,Ltd 58
Jiangsu Synthgene Biotechnology Co.,Ltd. 58
Aikon International Limited 58
Wuhu Huaren Science and Technology Co., Ltd. 64
Allbiosyn Biotechnology Co.,LTD 58
AMITT Biotechnology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Hongene Biotech Corporation 61
TCI (Shanghai) Development Co., Ltd. 81
Adamas Reagent, Ltd. 59

View Lastest Price from 2'-O-Methylguanosine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2'-O-Methylguanosine pictures 2026-09-04 2'-O-Methylguanosine
2140-71-8
 $99.00 1Kg 98% 1000KG Xinxiang Aurora Biotechnology Co.,Ltd.
2'-OMe Guanosine pictures 2026-09-04 2'-OMe Guanosine
2140-71-8
 $59.00-99.00 1Kg 98% 500kg Xinxiang Aurora Biotechnology Co.,Ltd.
2'-O-Methylguanosine pictures 2024-08-08 2'-O-Methylguanosine
2140-71-8
 1g 98% 100kg Hefei Huana Biomedical Technology Co.,Ltd.

2'-O-Methylguanosine Spectrum

2'-O-Methylguanosine(2140-71-8)1HNMR

2140-71-8(2'-O-Methylguanosine)Related Search:

Methyl hesperidin Guanosine Guanosine 5'-monophosphate disodium salt Acyclovir 7,8-Dihydro-7-methylguanosine
5'-Guanylic acid 2',3'-O-Isopropylideneguanosine 2',3',5'-Triacetylguanosine 1-METHYLGUANOSINE N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
N2-Isobutyryl-2'-O-Methyl-guanosine 2'-O-Methyl-N2-dimethylformamide-5'-O-DMT-Guanosine 2-Methylguanosine,N2-METHYLGUANOSINE,N-Methylguanosine N2-dimethylformamidine-2'-O-Methyl-guanosine 2'-O-Methyl-N2-Isobutyryl-5'-O-DMT-Guanosine
2'-C-Methylguanosine 2'-O-Methylguanosine 2'-(N-Methylanthraniloyl)guanosine 3',5'-Cyclicmonophosphate, Sodium Salt

1of4

2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]-3H-purin-6-one 2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-3H-purin-6-one 2-azanyl-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]-3H-purin-6-one 2'-OMe Guanosine 2'-O-Methyl-D-guanosine 2'-O-Methyl Guanosine, >=99% 2-aMino-9-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)-3-Methoxyoxolan-2-yl]-6,9-dihydro-1H-purin-6-one 2'-O-Methylguanosine Hydrate 2'-OMe-Gr 2'-O-MethylguanosineHydrate> Guanosine, 2'-O-methyl- 2'-O-Methylguanosine USP/EP/BP 2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one 2’-O-Methylguanosine,RNA modified nucleoside Gm Apoptosis,2’ OMe Guanosine,rRNA,inhibit,2’OMeGuanosine,Inhibitor,Nucleoside Antimetabolite/Analog,tRNA 2 '- Methoxyguanosine 2'-O-Methylguanosine 2'- 0 -Methylguanosine 2’-OMe-Guanosine, 10 mM in DMSO 2′,-O-Me-Guo 2'-O-Methylguanosine 2'-O-Methylguanosine - [X72830] 2'-OMe-G 2'-OMe-rG OMe-rG 2'-O-Methylguanosine C 2140-71-8 C11H15N5O5xH2O C11H15N5O5H2O Nucleotides Bases & Related Reagents Carbohydrates & Derivatives Heterocycles Nucleosides Modified（deoxy）nucleoside Nucleosides-2'-OMe Nucleosides