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2'-O-Methylguanosine

2'-O-Methylguanosine structure

CAS No.: 2140-71-8

Chemical Name:: 2'-O-Methylguanosine

Synonyms: OMe-rG;2'-OMe-G;2'-OMe-Gr;2'-OMe-rG;2'-OMe Guanosine;2′,-O-Me-Guo;2'-O-Methylguanosine;2'-O-Methylguanosine;2 '- Methoxyguanosine;2'- 0 -Methylguanosine

CBNumber:: CB2276641

Molecular Formula:: C11H15N5O5

Molecular Weight:: 297.27

MDL Number:: MFCD00057053

MOL File:: 2140-71-8.mol

MSDS File:: SDS

Last updated:2025-12-29 14:06:09

Product description	Number	Pack Size	Price
2'-O-Methylguanosine Hydrate >98.0%(HPLC)(T)	M2318	1g	$252
2'-O-Methylguanosine Hydrate >98.0%(HPLC)(T)	M2318	200mg	$80
2'-O-Methylguanosine ≥98%	21039	250mg	$57
2'-O-Methylguanosine ≥98%	21039	500mg	$93
2'-O-Methylguanosine ≥98%	21039	1g	$153
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2'-O-Methylguanosine Properties

Melting point	227-231°C (dec.)
Density	1.98±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Aqueous Base (Slightly), DMSO (Slightly),
pka	9?+-.0.20(Predicted)
form	Powder
color	White to Off-white
λmax	256 (pH 1)；258 (pH 11)
InChI	InChI=1S/C11H15N5O5/c1-20-7-6(18)4(2-17)21-10(7)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1
InChIKey	OVYNGSFVYRPRCG-KQYNXXCUSA-N
SMILES	OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](OC)[C@@H]1O
CAS DataBase Reference	2140-71-8(CAS DataBase Reference)
FDA UNII	W722H4PA1S

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38-22

Safety Statements

26-36-60-36/37

HS Code

29349990

NFPA 704

	0
2		0

2'-O-Methylguanosine price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	M2318	2'-O-Methylguanosine Hydrate >98.0%(HPLC)(T)	2140-71-8	1g	$252	2025-07-31	Buy
TCI Chemical	M2318	2'-O-Methylguanosine Hydrate >98.0%(HPLC)(T)	2140-71-8	200mg	$80	2025-07-31	Buy
Cayman Chemical	21039	2'-O-Methylguanosine ≥98%	2140-71-8	250mg	$57	2024-03-01	Buy
Cayman Chemical	21039	2'-O-Methylguanosine ≥98%	2140-71-8	500mg	$93	2024-03-01	Buy
Cayman Chemical	21039	2'-O-Methylguanosine ≥98%	2140-71-8	1g	$153	2024-03-01	Buy

Product number	Packaging	Price	Buy
M2318	1g	$252	Buy
M2318	200mg	$80	Buy
21039	250mg	$57	Buy
21039	500mg	$93	Buy
21039	1g	$153	Buy

2'-O-Methylguanosine Chemical Properties,Uses,Production

Description

2'-O-Methylguanosine is a nucleoside that contains a 2'-O-methyl group at the 2' position of the ribose. It is a component of many nucleic acids and is usually found as a minor component in RNA. 2'-O-Methylguanosine has been shown to be an inhibitor of DNA polymerase and an activator of RNA polymerase, which may be due to its ability to form hydrogen bonds with the phosphate backbone.

Chemical Properties

White Solid

Uses

Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.

Definition

ChEBI: Guanosine with the hydrogen on the hydroxyl at position C-2' substituted with a methyl group.

Synthesis

8-Thio-2'-O-methylguanosine (1 mmole) is dissolved in water and the solution is heated at reflux with Raney nickel for 6 h. The product is isolated by passing the solution through a short pad of celite and is further crystallizing to afford 2'-O-methylguanosine.

Physiological effects

2'-O-Methylguanosine is a modified nucleoside, it is thought to stabilize the structure of the tRNA.2'-O-Methylguanosine can also be found in rRNA. Normal and modified nucleosides, including 2'-O-methylguanosine, have been shown to be secreted by a natural suppressor cell line and induce apoptosis in K562/Molt4 target cells.

References

[1] B C PERSSON C G G J?ger. The spoU gene of Escherichia coli, the fourth gene of the spoT operon, is essential for tRNA (Gm18) 2’-O-methyltransferase activity.[J]. Nucleic Acids Research, 1997, 25 20: 4093-4097. DOI: 10.1093/nar/25.20.4093
[2] RYOTA YAMAGAMI. Folate-/FAD-dependent tRNA methyltransferase from Thermus thermophilus regulates other modifications in tRNA at low temperatures[J]. Genes to Cells, 2016, 21 7: 740-754. DOI: 10.1111/gtc.12376
[3] JAUNIUS URBONAVICIUS Glenn R B Jér?me M B Durand. Three modifications in the D and T arms of tRNA influence translation in Escherichia coli and expression of virulence genes in Shigella flexneri.[J]. Journal of Bacteriology, 2002, 184 19: 5348-5357. DOI: 10.1128/jb.184.19.5348-5357.2002
[4] MIROS?AWA Z. BARCISZEWSKA Jan B Tamara D Mashkova. The primary structure of lupin seed 5.8 S ribosomal RNA[J]. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1990, 1049 3: Pages 343-345. DOI: 10.1016/0167-4781(90)90108-e
[5] K SIRUM-CONNOLLY T L M. The role of nucleotide modifications in the yeast mitochondrial ribosome.[J]. Nucleic acids symposium series, 1995, 33: 73-75.
[6] TSUNEATSU MORI . Isolation and Identification of Apoptosis Inducing Nucleosides from CD57+HLA-DRbrightNatural Suppressor Cell Line[J]. Biochemical and biophysical research communications, 1998, 251 2: Pages 416-422. DOI: 10.1006/bbrc.1998.9423

2'-O-Methylguanosine synthesis

Synthesis of 2'-O-Methylguanosine from Triethylenediamine and 2-AMino-6-chloropurine-9-(2'-O-Methyl)riboside

2'-O-Methylguanosine Preparation Products And Raw materials

Raw materials

Preparation Products

2'-O-Methylguanosine Suppliers

Global( 289)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhu Nuowei chemistry Co., Ltd.	+86-0553-2911116-802 +86-18055326116	sales1@nuowei-chem.com	China	1628	58
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
Zhengzhou Chemprize Biotech Co., Ltd.	+86-86-0371-56768238 +8615981919713	sales@chemprize.com	China	297	58
Xinxiang Aurora Biotechnology Co.,Ltd.	+86-0086-0373-3088722 +8618637352520	info@aurora-biotech.com	China	112	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21600	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29837	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Nanjing Baifuli Technology Co., Ltd.	+86-15335185688	sales@unisyn.cn	CHINA	332	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58

Supplier	Advantage
Wuhu Nuowei chemistry Co., Ltd.	58
Yunbio Tech Co.,Ltd.	58
Zhengzhou Chemprize Biotech Co., Ltd.	58
Xinxiang Aurora Biotechnology Co.,Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Nanjing Baifuli Technology Co., Ltd.	58
Hubei xin bonus chemical co. LTD	58

View Lastest Price from 2'-O-Methylguanosine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-14	2'-O-Methylguanosine 2140-71-8	US $99.00 / Kg	1Kg	98%	1000KG	Xinxiang Aurora Biotechnology Co.,Ltd.
2026-01-14	2'-OMe Guanosine 2140-71-8	US $59.00-99.00 / Kg	1Kg	98%	500kg	Xinxiang Aurora Biotechnology Co.,Ltd.
2024-08-08	2'-O-Methylguanosine 2140-71-8	US $0.00 / g	1g	98%	100kg	Hefei Huana Biomedical Technology Co.,Ltd.

2'-O-Methylguanosine
2140-71-8
US $99.00 / Kg
98%
Xinxiang Aurora Biotechnology Co.,Ltd.

2'-OMe Guanosine
2140-71-8
US $59.00-99.00 / Kg
98%
Xinxiang Aurora Biotechnology Co.,Ltd.

2'-O-Methylguanosine
2140-71-8
US $0.00 / g
98%
Hefei Huana Biomedical Technology Co.,Ltd.

2'-O-Methylguanosine Spectrum

2'-O-Methylguanosine(2140-71-8)¹HNMR

2140-71-8(2'-O-Methylguanosine)Related Search:

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N2-Isobutyryl-2'-O-Methyl-guanosine 2'-O-Methyl-N2-dimethylformamide-5'-O-DMT-Guanosine 2-Methylguanosine,N2-METHYLGUANOSINE,N-Methylguanosine N2-dimethylformamidine-2'-O-Methyl-guanosine 2'-O-Methyl-N2-Isobutyryl-5'-O-DMT-Guanosine

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2'-OMe-G 2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]-3H-purin-6-one 2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-3H-purin-6-one 2-azanyl-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]-3H-purin-6-one 2'-OMe Guanosine 2'-O-Methyl-D-guanosine 2'-O-Methyl Guanosine, >=99% 2-aMino-9-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)-3-Methoxyoxolan-2-yl]-6,9-dihydro-1H-purin-6-one 2'-O-Methylguanosine Hydrate 2'-OMe-Gr 2'-O-MethylguanosineHydrate> Guanosine, 2'-O-methyl- 2'-OMe-rG 2'-O-Methylguanosine USP/EP/BP 2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one 2’-O-Methylguanosine,RNA modified nucleoside Gm Apoptosis,2’ OMe Guanosine,rRNA,inhibit,2’OMeGuanosine,Inhibitor,Nucleoside Antimetabolite/Analog,tRNA 2 '- Methoxyguanosine 2'-O-Methylguanosine 2'- 0 -Methylguanosine OMe-rG 2’-OMe-Guanosine, 10 mM in DMSO 2′,-O-Me-Guo 2'-O-Methylguanosine 2'-O-Methylguanosine - [X72830] 2140-71-8 C11H15N5O5xH2O C11H15N5O5H2O Nucleotides Bases & Related Reagents Carbohydrates & Derivatives Heterocycles Nucleosides Modified（deoxy）nucleoside Nucleosides-2'-OMe Nucleosides