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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 2'-O-Methylguanosine
2140-71-8

2'-O-Methylguanosine synthesis

12synthesis methods
8-Thio-2'-O-methylguanosine (1 mmole) is dissolved in water and the solution is heated at reflux with Raney nickel for 6 h. The product is isolated by passing the solution through a short pad of celite and is further crystallizing to afford 2'-O-methylguanosine.
2'-O-Methylguanosine
280-57-9 Synthesis
Triethylenediamine

280-57-9
595 suppliers
$5.00/5g

194034-59-8 Synthesis
2-AMino-6-chloropurine-9-(2'-O-Methyl)riboside

194034-59-8
18 suppliers
$1066.00/1g

2'-O-Methylguanosine

2140-71-8
249 suppliers
$20.20/250mg

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Yield:2140-71-8 1.25 g (65%)

Reaction Conditions:

in water;

Steps:

9 2'-O-Methyl Guanosine (9)

2'-O-Methyl Guanosine (9) A mixture of 5 (2.05 g, 6.5 mmol), 1,4-diazabicyclo[2.2.2]octane (1 equiv.) and water (30 mL) was heated to 90° C. for 45 minutes. Then the solution was cooled to ambient temperature, basified to pH 12 with 2M NaOH, and washed with methylene chloride (3*60 mL). The aqueous phase was acidified to pH 6 with 6M HCl and left at refrigerator overnight. Formed precipitate was filtered off. Mother liquor was evaporated to dryness, the residue was dissolved in water and applied to the short column with RP-18 silica gel. Solid phase was washed with water and remaining product was eluted with 5% aq methanol. Appropriate fractions were combined, evaporated to dryness and recrystallized from to provide 1.25 g (65%) of 2'-O-methyl guanosine 9. Analytical sample was recrystallized from water, m.p. The product was identical to authentic sample by HPLC, UV, 1 H-NMR-spectroscopy. 3',5'-di-O-Acetyl-2'-O-Methyl-6-Chloropurine Riboside (7)

References:

US5962675,1999,A

80791-87-3 Synthesis
2-AMINO-2'-O-METHYLADENOSINE

80791-87-3
62 suppliers
$26.40/250mg

2'-O-Methylguanosine

2140-71-8
249 suppliers
$20.20/250mg

References
Guanosine, 2'-O-methyl-3',5'-O-[methylenebis[bis(1-methylethyl)silylene]]-

572912-50-6
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2'-O-Methylguanosine

2140-71-8
249 suppliers
$20.20/250mg

References
194034-59-8 Synthesis
2-AMino-6-chloropurine-9-(2'-O-Methyl)riboside

194034-59-8
18 suppliers
$1066.00/1g

2'-O-Methylguanosine

2140-71-8
249 suppliers
$20.20/250mg

References
Guanosine, 2'-O-methyl-1-(phenylmethyl)- (9CI)

194034-67-8
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2'-O-Methylguanosine

2140-71-8
249 suppliers
$20.20/250mg

References

2'-O-Methylguanosine Related Search:

Acyclovir Guanosine 5'-monophosphate disodium salt Guanosine 7,8-Dihydro-7-methylguanosine 5'-Guanylic acid 2',3'-O-Isopropylideneguanosine 2',3',5'-Triacetylguanosine N2-Isobutyryl-2'-O-Methyl-guanosine guanosine 2',3',5'-tribenzoate 7-METHYLGUANOSINE