6-Nitroquinoline
- CAS No.
- 613-50-3
- Chemical Name:
- 6-Nitroquinoline
- Synonyms
- 40 kg;6-NitroquinoL;6-Nitrochinolin;6-nitro-quinolin;6-Nitroquinoline;6-Nittroquinoline;Quinoline,6-nitro-;6-Nitroquinoline>6-Nitroquinoline98%;6-Nitro Quinoline - 50g
- CBNumber:
- CB2332655
- Molecular Formula:
- C9H6N2O2
- Molecular Weight:
- 174.16
- MDL Number:
- MFCD00006799
- MOL File:
- 613-50-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 151-153 °C(lit.) |
|---|---|
| Boiling point | 305.12°C (rough estimate) |
| Density | 1.2190 (estimate) |
| refractive index | 1.6820 (rough estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| Water Solubility | Slightly soluble in water |
| form | powder to crystal |
| pka | 3.24±0.10(Predicted) |
| color | Needles from water or alc |
| BRN | 136138 |
| InChI | InChI=1S/C9H6N2O2/c12-11(13)8-3-4-9-7(6-8)2-1-5-10-9/h1-6H |
| InChIKey | SMHPLBXIVNQFBA-UHFFFAOYSA-N |
| SMILES | N1C2C(=CC([N+]([O-])=O)=CC=2)C=CC=1 |
| CAS DataBase Reference | 613-50-3(CAS DataBase Reference) |
| FDA UNII | 7033583N3J |
| EPA Substance Registry System | 6-Nitroquinoline (613-50-3) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H351 | |||||||||
| Precautionary statements | P201-P280-P301+P312-P302+P352+P312-P304+P340+P312-P308+P313 | |||||||||
| PPE | Eyeshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-40 | |||||||||
| Safety Statements | 7-22-36-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VC1900000 | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Carc. 2 |
|||||||||
| Toxicity | mma-sat 100 mmol/plate MUREAV 58,11,78 | |||||||||
| NFPA 704 |
|
6-Nitroquinoline price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N24005 | 6-Nitroquinoline 98% | 613-50-3 | 25g | $111 | 2026-04-30 | Buy |
| TCI Chemical | N0252 | 6-Nitroquinoline >98.0%(GC)(T) | 613-50-3 | 5g | $36 | 2026-04-30 | Buy |
| TCI Chemical | N0252 | 6-Nitroquinoline >98.0%(GC)(T) | 613-50-3 | 25g | $136 | 2026-04-30 | Buy |
| Usbiological | 285429 | 6-Nitroquinoline Asreported | 613-50-3 | 10g | $319 | 2026-06-03 | Buy |
| Usbiological | 285429 | 6-Nitroquinoline Asreported | 613-50-3 | 25g | $442 | 2026-06-03 | Buy |
6-Nitroquinoline Chemical Properties,Uses,Production
Chemical Properties
beige to light brown powder
Uses
6-Nitroquinoline serves as a precursor for synthesizing 6-hydroxylaminoquinoline via reduction with hydrazine hydrate in the presence of Raney nickel. It acts as a pro-fluorescent substrate that is converted to the fluorophore 6-aminoquinoline by xanthine/xanthine oxidase under hypoxic conditions, or to 6-nitroquinolin-2(1H)-one by xanthine oxidase under aerobic conditions. The compound is also employed for the quantitative determination and removal of palladium from solution using hot saturated aqueous conditions, and its electrochemical behavior allows for detection via polarographic and voltammetric methods[3][4][5].
Safety Profile
Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx. Seealso other nitroquinoline entries.
Synthesis
5332-25-2
613-50-3
GENERAL STEPS: 6-bromoquinoline (0.5 mmol), copper(II) trifluoromethanesulfonate (45 mg, 0.125 mmol), potassium nitrite (KNO2, 128 mg, 1.5 mmol), and anhydrous dimethylsulfoxide (DMSO, 0.6 mL) were sequentially added to a pre-dried oven-dried pressure tube under nitrogen protection. The pressure tube was sealed with a PTFE screw cap with a micro-valve and purged by nitrogen for 5 min to remove air. Subsequently, the reaction mixture was stirred at room temperature for 10 minutes and then gradually warmed up to 130°C and the reaction was continued at this temperature for 48 hours. Upon completion of the reaction, the mixture was cooled to room temperature, washed with excess ice water and extracted with ethyl acetate (3 x 10 mL). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography on silica gel (for entries 1-18 in Table 2) or basic alumina (for entries 19-23 in Table 2), using a solvent mixture of ethyl acetate and hexane as eluent, and the target product, 6-nitroquinoline, was finally obtained in good yield.
References
[1] Tetrahedron Letters, 2012, vol. 53, # 12, p. 1511 - 1513
[2] Tetrahedron, 2013, vol. 69, # 31, p. 6409 - 6414
[3]
Rajapakse, A., Linder, C., Morrison, R. D., Sarkar, U., Leigh, N. D., Barnes, C. L., Daniels, J. S., Gates, K. S. (2013). Enzymatic Conversion of 6-Nitroquinoline to the Fluorophore 6-Aminoquinoline Selectively under Hypoxic Conditions. Chemical Research in Toxicology, 26(4), 555–563. https://doi.org/10.1021/tx300483z
[4]
Vyskočil, V., Jiránek, I., Daňhel, A., Zima, J., Barek, J., Wang, J., Pecková, K. (2011). Polarographic and voltammetric determination of genotoxic nitro derivatives of quinoline using mercury electrodes. Collection of Czechoslovak Chemical Communications, 76(12), 1991–2004. https://doi.org/10.1135/cccc2011173
[5]
Ogburn, S. C., Riesmeyer, A. H. (1928). THE QUANTITATIVE DETERMINATION OF PALLADIUM BY MEANS OF 6-NITROQUINOLINE. Journal of the American Chemical Society, 50(11), 3018–3022. https://doi.org/10.1021/ja01398a023
6-Nitroquinoline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanzheng Green Lerves Mrterial Technology Co.,LTD. | 13909164069 | taohuang18@163.com | China | 30 | 58 |
| Nanbu County Chengxin Technology Co., Ltd. | 0838-5675166 15883665058 | nbcxkj@126.com | China | 956 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Lastest Price from 6-Nitroquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 6-NITROQUINOLINE
613-50-3
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2025-04-04 | 6-NITROQUINOLINE
613-50-3
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2022-02-25 | 6-Nitroquinoline
613-50-3
|
$2.00 | 1KG | 99% | 100kg | Hong Kong Tiansheng New Material Trading Co., Ltd |
-
- 6-NITROQUINOLINE
613-50-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 6-NITROQUINOLINE
613-50-3
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 6-Nitroquinoline
613-50-3
- $2.00
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
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