4-Bromo-3,5-dimethylisoxazole
- CAS No.
- 10558-25-5
- Chemical Name:
- 4-Bromo-3,5-dimethylisoxazole
- Synonyms
- SKL268;BUTTPARK 33\06-98;TIMTEC-BB SBB003784;4-Bromo-dimethylisoxazole;4-Bromo-3,5-dimethylisoxa...;4-BROMO-3,5-DIMETHYLISOXAZOLE;Isoxazole, 4-broMo-3,5-diMethyl-;4-Bromo-3,5-dimethylisoxazole >4-BROMO-3,5-DIMETHYLISOXAZOLE 97%;4-Bromo-3,5-dimethylisoxazole,97%
- CBNumber:
- CB2339447
- Molecular Formula:
- C5H6BrNO
- Molecular Weight:
- 176.01
- MDL Number:
- MFCD00068187
- MOL File:
- 10558-25-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Bromo-3,5-dimethylisoxazole 95% | 544299 | 1g | $21.9 |
| 4-Bromo-3,5-dimethylisoxazole 95% | 544299 | 5g | $63.4 |
| 4-Bromo-3,5-dimethylisoxazole >98.0%(GC) | B3519 | 1g | $20 |
| 4-Bromo-3,5-dimethylisoxazole >98.0%(GC) | B3519 | 5g | $79 |
| 4-Bromo-3,5-dimethylisoxazole ≥99%(GC) | 27803 | 5G | $18.53 |
| More product size | |||
| Boiling point | 176 °C(lit.) |
|---|---|
| Density | 1.478 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| pka | -2.35±0.28(Predicted) |
| form | clear liquid |
| color | Colorless to Light orange to Yellow |
| Sensitive | Light Sensitive |
| BRN | 108522 |
| InChI | InChI=1S/C5H6BrNO/c1-3-5(6)4(2)8-7-3/h1-2H3 |
| InChIKey | GYHZPSUAMYIFQD-UHFFFAOYSA-N |
| SMILES | O1C(C)=C(Br)C(C)=N1 |
| CAS DataBase Reference | 10558-25-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227 | |||||||||
| Precautionary statements | P210-P280-P403+P235-P501-P210e-P280a-P370+P378a-P501a | |||||||||
| PPE | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Keep Cold/Light Sensitive | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| NFPA 704 |
|
4-Bromo-3,5-dimethylisoxazole price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 544299 | 4-Bromo-3,5-dimethylisoxazole 95% | 10558-25-5 | 1g | $21.9 | 2023-06-20 | Buy |
| Sigma-Aldrich | 544299 | 4-Bromo-3,5-dimethylisoxazole 95% | 10558-25-5 | 5g | $63.4 | 2023-06-20 | Buy |
| TCI Chemical | B3519 | 4-Bromo-3,5-dimethylisoxazole >98.0%(GC) | 10558-25-5 | 1g | $20 | 2024-03-01 | Buy |
| TCI Chemical | B3519 | 4-Bromo-3,5-dimethylisoxazole >98.0%(GC) | 10558-25-5 | 5g | $79 | 2024-03-01 | Buy |
| Chem-Impex | 27803 | 4-Bromo-3,5-dimethylisoxazole ≥99%(GC) | 10558-25-5 | 5G | $18.53 | 2026-05-19 | Buy |
4-Bromo-3,5-dimethylisoxazole Chemical Properties,Uses,Production
Chemical Properties
clear colorless to light yellow liquid
Uses
4-Bromo-3,5-dimethylisoxazole may be used in the preparation of (tert-butyldimethylsilyl)-(3,5-dimethylisoxazol-4-yl)phenylamine and 3,3′,5,5′-tetramethyl-4,4′-diisoxazole.[21}
General Description
4-Bromo-3,5-dimethylisoxazole is also known as 3,5-dimethyl-4-bromoisoxazole.
Synthesis
300-87-8
10558-25-5
The general procedure for the synthesis of 4-bromo-3,5-dimethylisoxazole from 3,5-dimethylisoxazole is as follows: 1. Preparation of intermediate 105 (4-bromo-3,5-dimethyl-1,2-oxazole): DMF (53 mL) was added to a 250 mL round-bottomed flask fitted with a magnetic stirrer. 2. 3,5-dimethyl-1,2-oxazole (5.3 g, 54.57 mmol) and N-iodosuccinimide (11.659 g, 65.49 mmol) were sequentially added to the stirred DMF. 3. After completion of the addition, the reaction mixture was heated to 75°C and maintained for 3 hours. 4. Upon completion of the reaction, the mixture was diluted with ethyl acetate (100 mL). 5. The organic layer was washed sequentially with saturated NaHCO3 solution (100 mL), sodium thiosulfate solution (100 mL), water (200 mL) and brine (100 mL). 6. The organic layer was dried over anhydrous Na2SO4 and then concentrated under reduced pressure to remove the solvent to afford the target product 4-bromo-3,5-dimethyl-1,2-oxazole (6.1 g, 63.4% yield).
References
[1] Patent: WO2012/11125, 2012, A1. Location in patent: Page/Page column 148; 149
[2] Rend. Ist. lomb., 1936, vol. 69, p. 587,600
4-Bromo-3,5-dimethylisoxazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29816 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49955 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from 4-Bromo-3,5-dimethylisoxazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 4-Bromo-3,5-dimethylisoxazole
10558-25-5
|
US $1.00 / KG | 1KG | 98% | 100KG | Career Henan Chemical Co |
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- 4-Bromo-3,5-dimethylisoxazole
10558-25-5
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
