4-Bromo-3,5-dimethylisoxazole
- CAS No.
- 10558-25-5
- Chemical Name:
- 4-Bromo-3,5-dimethylisoxazole
- Synonyms
- SKL268;BUTTPARK 33\06-98;TIMTEC-BB SBB003784;4-Bromo-dimethylisoxazole;4-Bromo-3,5-dimethylisoxa...;4-BROMO-3,5-DIMETHYLISOXAZOLE;Isoxazole, 4-broMo-3,5-diMethyl-;4-Bromo-3,5-dimethylisoxazole >4-BROMO-3,5-DIMETHYLISOXAZOLE 97%;4-Bromo-3,5-dimethylisoxazole,97%
- CBNumber:
- CB2339447
- Molecular Formula:
- C5H6BrNO
- Molecular Weight:
- 176.01
- MDL Number:
- MFCD00068187
- MOL File:
- 10558-25-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 176 °C(lit.) |
|---|---|
| Density | 1.478 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| pka | -2.35±0.28(Predicted) |
| form | clear liquid |
| color | Colorless to Light orange to Yellow |
| Sensitive | Light Sensitive |
| BRN | 108522 |
| InChI | InChI=1S/C5H6BrNO/c1-3-5(6)4(2)8-7-3/h1-2H3 |
| InChIKey | GYHZPSUAMYIFQD-UHFFFAOYSA-N |
| SMILES | O1C(C)=C(Br)C(C)=N1 |
| CAS DataBase Reference | 10558-25-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227 | |||||||||
| Precautionary statements | P210-P280-P403+P235-P501-P210e-P280a-P370+P378a-P501a | |||||||||
| PPE | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Keep Cold/Light Sensitive | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| NFPA 704 |
|
4-Bromo-3,5-dimethylisoxazole price More Price(74)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 544299 | 4-Bromo-3,5-dimethylisoxazole 95% | 10558-25-5 | 1g | $21.9 | 2023-06-20 | Buy |
| Sigma-Aldrich | 544299 | 4-Bromo-3,5-dimethylisoxazole 95% | 10558-25-5 | 5g | $63.4 | 2023-06-20 | Buy |
| TCI Chemical | B3519 | 4-Bromo-3,5-dimethylisoxazole >98.0%(GC) | 10558-25-5 | 1g | $20 | 2024-03-01 | Buy |
| TCI Chemical | B3519 | 4-Bromo-3,5-dimethylisoxazole >98.0%(GC) | 10558-25-5 | 5g | $79 | 2024-03-01 | Buy |
| Usbiological | 266374 | 4-Bromo-3,5-dimethylisoxazole Asreported | 10558-25-5 | 25g | $372 | 2026-06-03 | Buy |
4-Bromo-3,5-dimethylisoxazole Chemical Properties, Uses, Production
Chemical Properties
clear colorless to light yellow liquid
Uses
4-Bromo-3,5-dimethylisoxazole may be used in the preparation of (tert-butyldimethylsilyl)-(3,5-dimethylisoxazol-4-yl)phenylamine and 3,3′,5,5′-tetramethyl-4,4′-diisoxazole.[21}
General Description
4-Bromo-3,5-dimethylisoxazole is also known as 3,5-dimethyl-4-bromoisoxazole.
Synthesis
300-87-8
10558-25-5
The general procedure for the synthesis of 4-bromo-3,5-dimethylisoxazole from 3,5-dimethylisoxazole is as follows: 1. Preparation of intermediate 105 (4-bromo-3,5-dimethyl-1,2-oxazole): DMF (53 mL) was added to a 250 mL round-bottomed flask fitted with a magnetic stirrer. 2. 3,5-dimethyl-1,2-oxazole (5.3 g, 54.57 mmol) and N-iodosuccinimide (11.659 g, 65.49 mmol) were sequentially added to the stirred DMF. 3. After completion of the addition, the reaction mixture was heated to 75°C and maintained for 3 hours. 4. Upon completion of the reaction, the mixture was diluted with ethyl acetate (100 mL). 5. The organic layer was washed sequentially with saturated NaHCO3 solution (100 mL), sodium thiosulfate solution (100 mL), water (200 mL) and brine (100 mL). 6. The organic layer was dried over anhydrous Na2SO4 and then concentrated under reduced pressure to remove the solvent to afford the target product 4-bromo-3,5-dimethyl-1,2-oxazole (6.1 g, 63.4% yield).
References
[1] Patent: WO2012/11125, 2012, A1. Location in patent: Page/Page column 148; 149
[2] Rend. Ist. lomb., 1936, vol. 69, p. 587,600
4-Bromo-3,5-dimethylisoxazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from 4-Bromo-3,5-dimethylisoxazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 4-Bromo-3,5-dimethylisoxazole
10558-25-5
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 4-Bromo-3,5-dimethylisoxazole
10558-25-5
- $1.00
- 98%
- Career Henan Chemical Co
