5-Nitro-2-hydroxy-4-methoxypyridine
- CAS No.
- 607373-82-0
- Chemical Name:
- 5-Nitro-2-hydroxy-4-methoxypyridine
- Synonyms
- 4-METHOXY-5-NITROPYRIDIN-2-OL;4-Methoxy-5-nitropyridin-2(1H);4-Methoxy-5-nitropyridin-2(1H)-one;4-Methoxy-5-nitro-1H-pyridin-2-one;4-Methoxy-5-nitro-2(1H)-pyridinone;5-Nitro-2-hydroxy-4-methoxypyridine;2-HYDROXY-4-METHOXY-5-NITROPYRIDINE;2(1H)-Pyridinone, 4-methoxy-5-nitro-;2(1H)-Pyridinone,4-methoxy-5-nitro-(9CI);2-Hydroxy-4-methoxy-5-nitropyridine ,98%
- CBNumber:
- CB2359559
- Molecular Formula:
- C6H6N2O4
- Molecular Weight:
- 170.12
- MDL Number:
- MFCD07367779
- MOL File:
- 607373-82-0.mol
- MSDS File:
- SDS
| Melting point | >161°C (dec.) |
|---|---|
| Boiling point | 345.7±42.0 °C(Predicted) |
| Density | 1.42±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Very Slightly) |
| pka | 7.12±0.10(Predicted) |
| form | Solid |
| color | Dark Beige to Brown |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| HS Code | 2933399990 |
5-Nitro-2-hydroxy-4-methoxypyridine price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-M262735-5G | 4-Methoxy-5-nitro-1H-pyridin-2-one | 607373-82-0 | 5g | $1511 | 2026-06-03 | Buy |
| TRC | TRC-M262735-500MG | 4-Methoxy-5-nitro-1H-pyridin-2-one | 607373-82-0 | 500mg | $376 | 2026-06-03 | Buy |
| TRC | TRC-M262735-1G | 4-Methoxy-5-nitro-1H-pyridin-2-one | 607373-82-0 | 1g | $574 | 2026-06-03 | Buy |
| Usbiological | 161468 | 4-Methoxy-5-nitro-1H-pyridin-2-one | 607373-82-0 | 500g | $665 | 2026-06-03 | Buy |
| Apolloscientific | OR14756 | 2-Hydroxy-4-methoxy-5-nitropyridine ≥95% | 607373-82-0 | 250mg | $55 | 2026-06-04 | Buy |
5-Nitro-2-hydroxy-4-methoxypyridine Chemical Properties, Uses, Production
Uses
2-Hydroxy-methoxy-5-nitropyridine is used in the preparation of Rho-Kinase inhibitors that display antihypertensive activity. Also it is used in the preparation of aminofurans as potent inhibitors of AKT kinase.
Synthesis
31872-62-5
607373-82-0
General procedure for the synthesis of 4-methoxy-5-nitropyridin-2(1H)-one from 4-methoxy-3-nitropyridine: 250 mL of anhydrous THF was added to a 1 L flask, cooled to -78 °C, and then concentrated NH3 (100-150 mL). Solid t-BuOK (200 mmol, 22.5 g) was added to THF and stirred vigorously for 10 min until completely dissolved. In another 500 mL flask, 4-methoxy-3-nitropyridine (12.3 g, 80 mmol) was dissolved in 100 mL of anhydrous THF and cooled to 0°C. To this solution was added t-BuOOH (88 mmol, 16 mL). The t-BuOOH/THF solution was then slowly added to an ammonia solution at -78 °C via a dropping funnel over 20 min. The reaction mixture was slowly warmed to -40 °C and stirred at this temperature for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated NH4Cl solution (20 mL) and the cooling bath was removed. The reaction mixture was stirred overnight at room temperature. The precipitate was collected by filtration and dried under vacuum to give a tan solid product (9.5 g, 70% yield). lC/MS analysis showed m/z 171 [M+H]+ as a single component.
References
[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 1, p. 2 - 5
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 5, p. 1508 - 1511
[3] Patent: WO2006/113837, 2006, A2. Location in patent: Page/Page column 36; 62-63
[4] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 1, p. 42 - 46
[5] Patent: WO2005/37197, 2005, A2. Location in patent: Page/Page column 94
5-Nitro-2-hydroxy-4-methoxypyridine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| ChemShuttle, Inc. | 0510-83588313-811 18800520310 | sales@chemshuttle.com | China | 2999 | 62 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Candia Thamtech Company Limited | 0371-86615086 18203638366 0371-86159066 13526786601 | China | 2011 | 60 | |
| Runpharm Technology Limited | 18171398856 2968382473 | service@runpharm.com | China | 716 | 55 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 4904 | 55 |
| Hebei Summedchem Co.,Ltd | 0319-5801333-8008 15630992918 | sales@summedchem.com | China | 1000 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Mashilabs (Shanghai) Co.,Ltd. | 19916721580 | mafarm@126.com | China | 4534 | 58 |
View Latest Price from 5-Nitro-2-hydroxy-4-methoxypyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 5-NITRO-2-HYDROXY-4-METHOXYPYRIDINE
607373-82-0
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-01-13 | 5-NITRO-2-HYDROXY-4-METHOXYPYRIDINE
607373-82-0
|
$9.80 | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- 5-NITRO-2-HYDROXY-4-METHOXYPYRIDINE
607373-82-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 5-NITRO-2-HYDROXY-4-METHOXYPYRIDINE
607373-82-0
- $9.80
- ≥98%
- Career Henan Chemical Co
