Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>3,5-Dimethoxyphenylacetonitrile

3,5-Dimethoxyphenylacetonitrile

3,5-Dimethoxyphenylacetonitrile Structure
3,5-Dimethoxyphenylacetonitrile structure
CAS No.
13388-75-5
Chemical Name:
3,5-Dimethoxyphenylacetonitrile
Synonyms
2-(3,5-dimethoxyphenyl)acetonitrile;NSC 245126;HOMOVERATONITRILE;TIMTEC-BB SBB005899;5-DiMethoxyphenylacetonitrile;3,5-Dimethoxyphenylacetonitrile;3,5-DIMETHOXY-BENZENEACETONITRILE;Benzeneacetonitrile,3,5-dimethoxy-;(3,5-DiMethoxyphenyl)acetonitrile 97%;3,5-Dimethoxyphenylacetonitrile, 98+%
CBNumber:
CB2372596
Molecular Formula:
C10H11NO2
Molecular Weight:
177.2
MDL Number:
MFCD00016395
MOL File:
13388-75-5.mol
MSDS File:
SDS
Last updated:2026-09-12 18:50:38
Request For Quotation

3,5-Dimethoxyphenylacetonitrile Properties

Melting point 54-57 °C(lit.)
Boiling point 316.7±27.0 °C(Predicted)
Density 1.082±0.06 g/cm3(Predicted)
Flash point >230 °F
storage temp. Sealed in dry,Room Temperature
solubility soluble in Dichloromethane, Ethyl Acetate
form powder to crystal
color White to Orange to Green
BRN 2096481
InChI InChI=1S/C10H11NO2/c1-12-9-5-8(3-4-11)6-10(7-9)13-2/h5-7H,3H2,1-2H3
InChIKey UUNRWZQWCNTSCV-UHFFFAOYSA-N
SMILES C1(CC#N)=CC(OC)=CC(OC)=C1
CAS DataBase Reference 13388-75-5(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H312
Precautionary statements  P280h
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,T
Risk Statements  22
Safety Statements  36/37-24/25
RIDADR  3439
WGK Germany  3
HazardClass  6.1
PackingGroup  III
HS Code  29269090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
NFPA 704
1
2 0

3,5-Dimethoxyphenylacetonitrile price More Price(62)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 591149 (3,5-Dimethoxyphenyl)acetonitrile 97% 13388-75-5 1g $90.5 2023-06-20 Buy
TCI Chemical D5186 3,5-Dimethoxyphenylacetonitrile >98.0%(GC) 13388-75-5 1g $55 2026-04-30 Buy
TCI Chemical D5186 3,5-Dimethoxyphenylacetonitrile >98.0%(GC) 13388-75-5 5g $167 2026-04-30 Buy
TRC TRC-D460585-500MG (3,5-Dimethoxyphenyl)acetonitrile 13388-75-5 500mg $65 2026-06-03 Buy
TRC TRC-D460585-2.5G (3,5-Dimethoxyphenyl)acetonitrile 13388-75-5 2.5g $109 2026-06-03 Buy
Product number Packaging Price Buy
591149 1g $90.5 Buy
D5186 1g $55 Buy
D5186 5g $167 Buy
TRC-D460585-500MG 500mg $65 Buy
TRC-D460585-2.5G 2.5g $109 Buy

3,5-Dimethoxyphenylacetonitrile Chemical Properties, Uses, Production

Chemical Properties

Yellow Solid

Uses

(3,5-Dimethoxyphenyl)acetonitrile (cas# 13388-75-5) is a compound useful in organic synthesis.

Synthesis

Trimethylsilyl cyanide

7677-24-9

3,5-DIMETHOXYBENZYL BROMIDE

877-88-3

3,5-DIMETHOXYPHENYLACETONITRILE

13388-75-5

General procedure for the synthesis of 3,5-dimethoxyphenylacetonitrile from trimethylsilyl cyanide and 3,5-dimethoxybenzyl bromide: In 100 mL of acetonitrile, 2.310 g (0.01 mol) of 3,5-dimethoxy-4-bromobenzyl bromide, 1.485 g (0.015 mol) of trimethylsilyl cyanide, and 4.725 g (0.015 mol) of tetra butylammonium fluoride in a 30 mL three-neck flask. The mixture was stirred and heated to reflux and the reaction was carried out for 6 hours, during which time the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, it was cooled to room temperature and the reaction solution was poured into 100 mL of ice water and stirred until a white solid precipitated. The solid was collected by filtration, washed with 50% methanol and dried to afford the target compound 3,5-dimethoxyphenylacetonitrile in 66.7% yield.

Purification Methods

Crystallise the nitrile from MeOH or pet ether (b 90-110o). [Adams et al. J Am Chem Soc 70 664 1948, Sankaraman et al. J Am Chem Soc 109 5235 1987, Beilstein 10 I 198, 10 II 269, 10 III 1470.]

References

[1] Patent: CN105503652, 2016, A. Location in patent: Paragraph 0048; 0049
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 1, p. 81 - 85

3,5-Dimethoxyphenylacetonitrile synthesis

7677-24-9
877-88-3
13388-75-5
Synthesis of 3,5-Dimethoxyphenylacetonitrile from Trimethylsilyl cyanide and 3,5-Dimethoxybenzyl bromide

3,5-Dimethoxyphenylacetonitrile Preparation Products And Raw materials

Raw materials

Sodium borohydride Sodium cyanide Methanol Dimethyl sulfoxide 3,5-Dimethoxybenzaldehyde
Phosphorus tribromide Trimethylsilyl cyanide 3,5-Dimethoxybenzyl bromide Acetonitrile Tetrabutylammonium Fluoride

1of2

Preparation Products

3,5-Dimethoxyphenylacetonitrile Suppliers

Global Suppliers ( 211)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Jia Xing Isenchem Co.,Ltd 66
Pure Chemistry Scientific Inc. 62

View Latest Price from 3,5-Dimethoxyphenylacetonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dobutamine Impurity 46 pictures 2025-12-16 Dobutamine Impurity 46
13388-75-5
 10mg 99%+ HPLC 1000 Moxin Chemicals
(3,5-Dimethoxyphenyl)acetonitrile pictures 2021-07-02 (3,5-Dimethoxyphenyl)acetonitrile
13388-75-5
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
3,5-DIMETHOXYPHENYLACETONITRILE pictures 2019-07-06 3,5-DIMETHOXYPHENYLACETONITRILE
13388-75-5
 $8.00 1kg 99% 100KG Career Henan Chemical Co

3,5-Dimethoxyphenylacetonitrile Spectrum

3,5-DIMETHOXYPHENYLACETONITRILE(13388-75-5)1HNMR

13388-75-5 (3,5-Dimethoxyphenylacetonitrile) Related Search:

Nexopamil Dagapamil 3,4,5-Trimethoxyphenylacetonitrile 3,5-DIMETHOXYPHENYLACETONITRILE,3,4-DIMETHOXYPHENYLACETONITRILE / HOMOVERATRONITRILE 3,5-Dimethoxyphenylacetonitrile
2,5-Dimethoxyphenylacetonitrile Methoxy-(-)-verapamil hydrochloride Verapamil 2-BROMO-4,5-DIMETHOXYPHENYLACETONITRILE,6-BROMO-3,4-DIMETHOXYPHENYLACETONITRILE 2-Fluoro-3,4-dimethoxyphenylacetonitrile
2,3-Dimethoxyphenylacetonitrile l-a-Isopropyl-a-[(N-methyl-N-homoveratryl)-g-aminopropyl]-3,4-dimethoxyphenylacetonitrile Methoxyverapamil hydrochloride 3,4,5-trimethoxy-alpha-(1-methylethyl)phenylacetonitrile 1-(3,5-Dimethoxy-phenyl)-cyclopentanecarbonitrile
3,5-Dimethoxy-4-hydroxyphenyl acetonitrile 2-(3,5-Dimethoxy-phenyl)-2-methyl-propionitrile norgallopamil

1of4

HOMOVERATONITRILE 3,5-DIMETHOXY-BENZENEACETONITRILE 3,5-Dimethoxyphenylacetonitrile, 98+% Benzeneacetonitrile,3,5-dimethoxy- 5-DiMethoxyphenylacetonitrile NSC 245126 (3,5-DiMethoxyphenyl)acetonitrile 97% TIMTEC-BB SBB005899 2-(3,5-dimethoxyphenyl)acetonitrile 3,5-Dimethoxyphenylacetonitrile 13388-75-5 CH3O2C6H3CH2CN C10 to C27 Building Blocks Biochemicals and Reagents BioChemical Fluorescent Indicators and Probes Fluorescent Probes, Labels, Particles and Stains Alphabetical Detection Cyanides/Nitriles Organic Building Blocks pH Sensitive Probes and Indicators Nitrogen Compounds Aromatics Intermediates Miscellaneous Reagents Aromatic Nitriles C10 to C27 Cyanides/Nitriles Nitrogen Compounds