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Flunarizine dihydrochloride

Flunarizine dihydrochloride Structure
Flunarizine dihydrochloride structure
CAS No.
30484-77-6
Chemical Name:
Flunarizine dihydrochloride
Synonyms
FLUNARIZINE HYDROCHLORIDE;FLUNARIZINE HCL;Gradient;FLUNARIZINE 2HCL;Flunarizine dihydrochloride CRS;Flunarizine Dihydrochloride (EP/BP);Issium;Mondus;r14950;Flunarl
CBNumber:
CB2377940
Molecular Formula:
C26H28Cl2F2N2
Molecular Weight:
477.42
MDL Number:
MFCD00058198
MOL File:
30484-77-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
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Flunarizine dihydrochloride Properties

Melting point 188-190C
storage temp. 2-8°C
solubility chloroform/methanol (9:1): 50 mg/mL, clear, colorless
form Solid
color White to Off-White
Merck 13,4170
BRN 4284243
InChI InChI=1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;
InChIKey RXKMOPXNWTYEHI-RDRKJGRWSA-N
SMILES C(C1C=CC(F)=CC=1)(C1=CC=C(F)C=C1)N1CCN(C/C=C/C2C=CC=CC=2)CC1.Cl.Cl
CAS DataBase Reference 30484-77-6(CAS DataBase Reference)
FDA UNII C11102TO53
UNSPSC Code 41116107
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312+P330-P501
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
RTECS  TK9187000
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
NFPA 704
0
2 0

Flunarizine dihydrochloride price More Price(67)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F8257 Flunarizine dihydrochloride ≥98% (TLC) 30484-77-6 1g $92 2026-04-30 Buy
Sigma-Aldrich F8257 Flunarizine dihydrochloride ≥98% (TLC) 30484-77-6 10g $516 2026-04-30 Buy
Sigma-Aldrich F0189900 Flunarizine dihydrochloride European Pharmacopoeia (EP) Reference Standard 30484-77-6 50 mg $241 2026-04-30 Buy
TCI Chemical B6727 Flunarizine Dihydrochloride 30484-77-6 25G $68 2026-04-30 Buy
Cayman Chemical 20385 Flunarizine (hydrochloride) ≥98% 30484-77-6 1g $40 2026-04-30 Buy
Product number Packaging Price Buy
F8257 1g $92 Buy
F8257 10g $516 Buy
F0189900 50 mg $241 Buy
B6727 25G $68 Buy
20385 1g $40 Buy

Flunarizine dihydrochloride Chemical Properties, Uses, Production

Chemical Properties

White Solid

Originator

Sibelium,Janssen,W. Germany,1977

Uses

Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.

Uses

antipsychotic, H1 antihistamine

Uses

Calcium channel blocker; fluorinated derivative of Cinnarizine. Vasodilator (cerebral and peripheral). This is the labeled analog.

Definition

ChEBI: Flunarizine hydrochloride is a diarylmethane.

Manufacturing Process

A mixture of 14.3 parts of di-(p-fluorophenyl)-chloromethane, 10.1 parts of 1- cinnamylpiperazine, 12.7 parts of sodium carbonate, a few crystals of potassium iodide in 200 parts of 4-methyl-2-pentanone is stirred and refluxed for 21 hours. The reaction mixture is cooled and 50 parts of water are added. The organic layer is separated, dried, filtered and evaporated.
The oily residue is dissolved in 480 parts of anhydrous diisopropyl ether. This solution is boiled with activated charcoal, filtered and to the clear filtrate is added an excess of 2-propanol, previously saturated with gaseous hydrogen chloride. The precipitated salt is filtered off and recrystallized from a mixture of 2-propanol and ethanol, yielding 1-cinnamyl-4-(di-p-fluorobenzhydryl) piperazine dihydrochloride, MP 251.5°C.

Therapeutic Function

Vasodilator

General Description

Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.

Biological Activity

Dual Na + /Ca 2+ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective.

Biochem/physiol Actions

Blocks T-type Ca2+/Na+ channels; inhibits K+-induced catecholamine release from chromaffin cells

Flunarizine dihydrochloride Preparation Products And Raw materials

Raw materials

Fluorobenzene Cinnamyl alcohol Piperazine Fluoroboric acid 4,4'-Methylenedianiline
Sodium carbonate trans-1-Cinnamylpiperazine

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Preparation Products

Flunarizine dihydrochloride Suppliers

Global Suppliers ( 438)
Supplier Tel Email Country ProdList Advantage
Shanxi Zhendong Ante Biological Pharmaceutical Co., Ltd. -- zdat@zdjt.com China 6 58
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2202 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
ShengXiong Biological Technology Development Co., Ltd. 86-021-64960112 13774219177 alpha9196@gmail.com China 52 65
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Supplier Advantage
Shanxi Zhendong Ante Biological Pharmaceutical Co., Ltd. 58
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Energy Chemical 61
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Adamas Reagent, Ltd. 59
ShengXiong Biological Technology Development Co., Ltd. 65
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50

View Latest Price from Flunarizine dihydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Flunarizine dihydrochloride pictures 2026-09-16 Flunarizine dihydrochloride
30484-77-6
 0.99 RongNa Biotechnology Co.,Ltd
Flunarizine dihydrochloride pictures 2026-08-25 Flunarizine dihydrochloride
30484-77-6
 1kg 0.99 1000kg Shaanxi Xianhe Biotech Co., Ltd
Flunarizine dihydrochloride pictures 2026-07-15 Flunarizine dihydrochloride
30484-77-6
 $40.00 99.99% 10g TargetMol Chemicals Inc.

Flunarizine dihydrochloride Spectrum

Flunarizine dihydrochloride(30484-77-6)1HNMR

30484-77-6 (Flunarizine dihydrochloride) Related Search:

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Flugeral Flunarl Fluxarten Gradient Issium Flunarizine dihydrochloride,1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride Flunarizine-d8 dihydrochloride 1-[Bis(4-fluorophenyl)Methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]piperazine Hydrochloride Dinaplex Flunagen Mondus Piperazine,1-[bis(4-fluorophenyl)Methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-, hydrochloride(1:2) 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-piperazine,hydrochloride (1:2) (e)-1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)piperazinedihydroch 1-(BIS[4-FLUOROPHENYL]) DIHYDROCHLORIDE 1-[BIS(4-FLUOROPHENYL)METHYL]-4-(3-PHENYL-2-PROPENYL)PIPERAZINE 2 HCL 1-[BIS(4-FLUOROPHENYL)METHYL]-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLO RIDE (e)-1-(bis(p-fluorophenyl)methyl)-4-cinnamylpiperazinedihydrochloride 1-(bis(p-fluorophenyl)methyl)-4-cinnamyl-,dihydrochloride,(e)-piperazin kw-3149 r14950 (E)-1-[BIS(4-FLUOROPHENYL)METHYL]-4-(3-PHENYL-2-PROPENYL)PIPERAZINE DIHYDROCHLORIDE FLUNARIZINE DIHYDROCHLORIDE Flunarizine, DiHCl (E)-1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine dihydrochloride FLUNARIZINE DIHYDROCHLORIDE CA2+/NA+ CHA NNEL ANTA FLUNARIZIN-DIHYDROCHLORIDE FLUNARIZINE HYDROCHLORIDE EPF(CRM STANDARD) 1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine dihydrochloride Flunarizine dihydrochloride CRS Flunarizine dihydrochloride for system suitability CRS Flunarizine dihydrochloride USP/EP/BP Flunarizine dihydrochloride for system suitability (Y0000266) 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine dihydrochloride FLURIZINE EP IMPURITY D Flunarizine dihydrochloride, 10 mM in DMSO Flunarizine for system suitability Flunarizine dihydrochloride - Bio-X ? Flunarizine Dihydrochloride 1.0 mg/ml in Methanol (as free base) D8-Flunarizine Dihydrochloride Flunarizine Dihydrochloride (EP/BP) FLUNARIZINE 2HCL FLUNARIZINE HCL FLUNARIZINE HYDROCHLORIDE Flunarizine dihydrochloride 99% Flunarizine dihydrochloride 99.5% 30484-77-6 30784-77-6 30848-77-6 C26H26F2N22HCl C26H26F2N22ClH C26H28Cl2F2N2 C26H28F2N2 47742 Alphabetic FA - FL Voltage-gated Ion Channels BioChemical