2-Fluoropyridine-5-boronic acid
- CAS No.
- 351019-18-6
- Chemical Name:
- 2-Fluoropyridine-5-boronic acid
- Synonyms
- 2-Fluoropyridine-5-Boronic;AKOS BRN-0471;CAS:351019-18-6;RARECHEM AK ML 0441;2-fluoro-5-pyridine borate;2-FLUORO-5-PYRIDYLBORONIC ACID;2-FLUOROPYRIDIN-5-BORONIC ACID;6-fluoro-3-pyridylboronic acid;2-Fluoropyridyl-5-boronic acid;6-FLUOROPYRIDINE-3-BORONIC ACID
- CBNumber:
- CB2384003
- Molecular Formula:
- C5H5BFNO2
- Molecular Weight:
- 140.91
- MDL Number:
- MFCD03411559
- MOL File:
- 351019-18-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 177-178°C (dec.) |
|---|---|
| Boiling point | 311.5±52.0 °C(Predicted) |
| Density | 1.34±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 6.97±0.10(Predicted) |
| color | White to Almost white |
| BRN | 8974962 |
| InChI | InChI=1S/C5H5BFNO2/c7-5-2-1-4(3-8-5)6(9)10/h1-3,9-10H |
| InChIKey | OJBYZWHAPXIJID-UHFFFAOYSA-N |
| SMILES | B(C1=CC=C(F)N=C1)(O)O |
| CAS DataBase Reference | 351019-18-6(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Fluoropyridine-5-boronic acid price More Price(85)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 639184 | 6-Fluoro-3-pyridinylboronic acid | 351019-18-6 | 1g | $28.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 639184 | 6-Fluoro-3-pyridinylboronic acid | 351019-18-6 | 5g | $78.5 | 2026-04-30 | Buy |
| TCI Chemical | F0770 | 2-Fluoropyridine-5-boronic Acid (contains varying amounts of Anhydride) | 351019-18-6 | 1g | $41 | 2026-04-30 | Buy |
| TCI Chemical | F0770 | 2-Fluoropyridine-5-boronic Acid (contains varying amounts of Anhydride) | 351019-18-6 | 5g | $139 | 2026-04-30 | Buy |
| Usbiological | 276111 | 6-Fluoropyridine-3-boronic acid | 351019-18-6 | 10g | $382 | 2026-06-03 | Buy |
2-Fluoropyridine-5-boronic acid Chemical Properties, Uses, Production
Chemical Properties
white to light yellow solid
Uses
suzuki reaction
Uses
Used in a synthesis of halohydroxypyridines by hydroxydeboronation with basic hydrogen peroxide.
Synthesis
766-11-0
351019-18-6
The general procedure for the synthesis of 2-fluoropyridine-5-boronic acid from 2-fluoro-5-bromopyridine is as follows: 1. in a 72 L reactor equipped with a reflux condenser and temperature probe, 5-bromo-2-fluoropyridine (1.17 L, 0.568 mol), toluene (18.2 L) and triisopropyl borate (3.13 L, 0.68 mol, 1.2 eq.) were added and stirring was initiated. 2. tetrahydrofuran (4.4L) was added to the reactor and the reaction mixture was cooled to -35 to -50°C. 3. n-Butyllithium (2.5M hexane solution, 5.44L, 0.68mol, 1.2 eq.) was added slowly and dropwise while maintaining the temperature of the reaction mixture between -35 and -45 °C. 4. after 5 hours of reaction, confirming that the reaction is complete, the reaction mixture is slowly warmed to -15 to -20 °C. 5. 2M HCl (11.80L) was slowly added to the reaction mixture while maintaining the temperature between -15°C and 0°C. 6. The reaction mixture was stirred at 18 to 23 °C for 16 h followed by phase separation. 7. The organic phase was extracted with 6 M sodium hydroxide (6.0 L). 8. The acidic and basic aqueous phases were combined in a reactor and the pH was adjusted to 7.5 by slowly adding 6M HCl (2.5L). 9. Sodium chloride (6.0 kg) was added to the aqueous phase, followed by extraction with THF (3 x 20 L). 10. The organic phases were combined, dried with magnesium sulfate, and concentrated to give 1300 g of brown solid in 81% crude yield.
References
[1] Patent: WO2009/51848, 2009, A1. Location in patent: Page/Page column 65
[2] Tetrahedron, 2002, vol. 58, # 14, p. 2885 - 2890
[3] Journal of Medicinal Chemistry, 2005, vol. 48, # 1, p. 224 - 239
[4] Synthesis, 2003, # 7, p. 1035 - 1038
[5] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 10, p. 2858 - 2862
2-Fluoropyridine-5-boronic acid Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Liaoning Tianhua Chemical Co., Ltd. | 0418-6530555 2855550 | China | 338 | 69 | |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from 2-Fluoropyridine-5-boronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2-Fluoropyridine-5-boronic acid
351019-18-6
|
$1.10-36.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-05-23 | 2-Fluoropyridine-5-boronic acid
351019-18-6
|
$10.00 | 1kg | 99% | 20 ton | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2021-07-13 | 2-Fluoropyridine-5-boronic acid
351019-18-6
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-Fluoropyridine-5-boronic acid
351019-18-6
- $1.10-36.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Fluoropyridine-5-boronic acid
351019-18-6
- $10.00
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- 2-Fluoropyridine-5-boronic acid
351019-18-6
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
