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ChemicalBook >> CAS DataBase List >>2-Amino-4,5-dimethyl-thiophene-3-carboxylic acid methyl ester

2-Amino-4,5-dimethyl-thiophene-3-carboxylic acid methyl ester

2-Amino-4,5-dimethyl-thiophene-3-carboxylic acid methyl ester Structure
2-Amino-4,5-dimethyl-thiophene-3-carboxylic acid methyl ester structure
CAS No.
4651-93-8
Chemical Name:
2-Amino-4,5-dimethyl-thiophene-3-carboxylic acid methyl ester
Synonyms
AKOS 92456;AKOS B000679;AKOS NCG-0059;ART-CHEM-BB B000679;SPECS AK-968/37166326;METHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE;METHYL 2-AMINO-4,5-DIMETHYL-3-THIOPHENECARBOXYLATE;2-AMINO-4,5-DIMETHYL-3-THIOPHENECARBOXYLIC ACID METHYL ESTER;2-Amino-4,5-dimethyl-thiophene-3-carboxylic acid methyl ester;3-Thiophenecarboxylic acid, 2-amino-4,5-dimethyl-, methyl ester
CBNumber:
CB2391373
Molecular Formula:
C8H11NO2S
Molecular Weight:
185.24
MDL Number:
MFCD00461707
MOL File:
4651-93-8.mol
MSDS File:
SDS
Last updated:2026-09-12 18:51:17
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2-Amino-4,5-dimethyl-thiophene-3-carboxylic acid methyl ester Properties

Melting point 123-125 °C
Boiling point 287.8±35.0 °C(Predicted)
Density 1+-.0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 0.55±0.10(Predicted)
Appearance Light yellow to yellow Solid
InChIKey MZBOBUPJGXDOFT-UHFFFAOYSA-N
CAS DataBase Reference 4651-93-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xi
HazardClass  IRRITANT

2-Amino-4,5-dimethyl-thiophene-3-carboxylic acid methyl ester price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich TMT00479 Methyl 2-amino-4,5-dimethylthiophene-3-carboxylate 4651-93-8 1g $512 2023-01-07 Buy
Matrix Scientific 028833 Methyl 2-amino-4,5-dimethylthiophene-3-carboxylate 4651-93-8 500.00mg $189 2026-05-18 Buy
Synthonix M46935 Methyl 2-amino-4,5-dimethylthiophene-3-carboxylate 95+% 4651-93-8 1g $55 2026-05-06 Buy
Synthonix M46935 Methyl 2-amino-4,5-dimethylthiophene-3-carboxylate 95+% 4651-93-8 5g $59 2026-05-06 Buy
Synthonix M46935 Methyl 2-amino-4,5-dimethylthiophene-3-carboxylate 95+% 4651-93-8 10g $60 2026-05-06 Buy
Product number Packaging Price Buy
TMT00479 1g $512 Buy
028833 500.00mg $189 Buy
M46935 1g $55 Buy
M46935 5g $59 Buy
M46935 10g $60 Buy

2-Amino-4,5-dimethyl-thiophene-3-carboxylic acid methyl ester Chemical Properties, Uses, Production

Synthesis

2-Butanone

78-93-3

Methyl cyanoacetate

105-34-0

2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER

4651-93-8

The general procedure for the synthesis of methyl 2-amino-3,5-dimethylthiophene-3-carboxylate from 2-butanone and methyl cyanoacetate was as follows: sulfur powder (160.0 mg, 5.0 mmol) was placed in a single-necked flask and 1.5 mL of DMF was added to dissolve it. Methyl cyanoacetate (495.4 mg, 5.0 mmol) and morpholine (435.6 mg, 5.0 mmol) were then added sequentially, and the reaction solution immediately changed to dark brown color. Then 2-butanone (901.4 mg, 12.5 mmol) was added and the reaction mixture was stirred at 50 °C overnight. After completion of the reaction, the mixture was cooled to room temperature, diluted with an appropriate amount of water and extracted three times with ethyl acetate. The organic phases were combined, washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give the crude product. Finally, the crude product was separated and purified by column chromatography to give a light yellow solid target compound in 40.7% yield.

References

[1] Patent: CN106167497, 2016, A. Location in patent: Paragraph 0414; 0415; 0416
[2] ChemMedChem, 2018,
[3] European Journal of Medicinal Chemistry, 2019, vol. 161, p. 239 - 251

2-Amino-4,5-dimethyl-thiophene-3-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

2-Butanone Methyl cyanoacetate Sulfur Morpholine N,N-Dimethylformamide

Preparation Products

3-Allyl-5,6-dimethyl-2-thioxo-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-one

2-Amino-4,5-dimethyl-thiophene-3-carboxylic acid methyl ester Suppliers

Global Suppliers ( 66)
Supplier Tel Email Country ProdList Advantage
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
Yancheng Orgunion Pharmaceutical Sci & Tech Co., Ltd. 0515-89701588 13770166955 orgunion@orgunion.com China 620 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66028182 17714375163 yftan@aikonchem.com China 16674 50
Wuhan Chemwish Technology Co.， Ltd 027-67849912 sales@chemwish.com China 9144 60
Henan CoreyChem Co., Ltd 0371-86658258 info@coreychem.com China 10442 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Supplier Advantage
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Hangzhou Sage Chemical Co., Ltd. 58
Yancheng Orgunion Pharmaceutical Sci & Tech Co., Ltd. 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 50
Wuhan Chemwish Technology Co.， Ltd 60
Henan CoreyChem Co., Ltd 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Amadis Chemical Company Limited 58

View Latest Price from 2-Amino-4,5-dimethyl-thiophene-3-carboxylic acid methyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER pictures 2026-08-20 2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER
4651-93-8
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited

2-Amino-4,5-dimethyl-thiophene-3-carboxylic acid methyl ester Spectrum

2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER(4651-93-8)1HNMR

4651-93-8 (2-Amino-4,5-dimethyl-thiophene-3-carboxylic acid methyl ester) Related Search:

Diethyl 5-amino-3-methyl-2,4-thiophenedicarboxylate Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate 2-Amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid methyl ester 5-Amino-3-methyl-thiophene-2,4-dicarboxylic acid dimethyl ester 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid ethyl ester
2-Amino-4-methyl-5-phenylcarbamoyl-thiophene-3-carboxylic acid methyl ester Ethyl 2-acetamido-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate Ethyl 2-[(2-chloroacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate ethyl 5-acetyl-2-amino-4-methyl-thiophene-3-carboxylate BUTTPARK 123\48-20
AKOS 89941 AURORA 3766 BUTTPARK 128\48-16 AKOS 93369 Ethyl 2-[2-(2,4-dichlorophenoxy)acetamido]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
Ethyl 2-(((4-(trifluoromethoxy)phenyl)amino)carbonylamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate Ethyl 2-(((4-chlorophenyl)amino)carbonylamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate Ethyl 2-((thioxo((4-(trifluoromethoxy)phenyl)amino)methyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

1of4

SPECS AK-968/37166326 ART-CHEM-BB B000679 METHYL 2-AMINO-4,5-DIMETHYL-3-THIOPHENECARBOXYLATE METHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE AKOS B000679 AKOS 92456 AKOS NCG-0059 3-Thiophenecarboxylic acid, 2-amino-4,5-dimethyl-, methyl ester 2-AMINO-4,5-DIMETHYL-3-THIOPHENECARBOXYLIC ACID METHYL ESTER 2 - AMino-3, 5 - diMethyl-thiophene-3 - carboxylic acid Methyl ester 2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER ISO 9001：2015 REACH 2-Amino-4,5-dimethyl-thiophene-3-carboxylic acid methyl ester 4651-93-8 C8H11NO2S Thiophene&Benzothiophene Thiophene