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Roquinimex

Roquinimex Structure
Roquinimex structure
CAS No.
84088-42-6
Chemical Name:
Roquinimex
Synonyms
FCF89;CS-1231;LS-2616;LINOMIDE;ABR212616;ROQUINIMEX;PNU 212616;Roquinimex(Linomide);Roquinimex, 10 mM in DMSO;N,1-Dimethyl-N-phenyl-2-oxo-4-hydroxy-1,2-dihydroquinoline-3-carboxamide
CBNumber:
CB2391777
Molecular Formula:
C18H16N2O3
Molecular Weight:
308.33
MDL Number:
MFCD00866331
MOL File:
84088-42-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Roquinimex Properties

Melting point 200-204°
Boiling point 436.2±45.0 °C(Predicted)
Density 1.357±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility DMSO: 11 mg/mL
form solid
pka 4.50±1.00(Predicted)
color White to off-white
Merck 14,8259
FDA UNII 372T2944C0
NCI Drug Dictionary Linomide
ATC code L03AX02

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312a-P330-P501a
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36/37
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
HS Code  2933.49.2600
NFPA 704
0
2 0

Roquinimex price More Price(58)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical L0270 Linomide >98.0%(HPLC) 84088-42-6 10mg $122 2026-04-30 Buy
Cayman Chemical 30206 Roquinimex ≥98% 84088-42-6 5mg $98 2026-04-30 Buy
Cayman Chemical 30206 Roquinimex ≥98% 84088-42-6 10mg $185 2026-04-30 Buy
Cayman Chemical 30206 Roquinimex ≥98% 84088-42-6 50mg $435 2026-04-30 Buy
Cayman Chemical 30206 Roquinimex ≥98% 84088-42-6 100mg $770 2026-04-30 Buy
Product number Packaging Price Buy
L0270 10mg $122 Buy
30206 5mg $98 Buy
30206 10mg $185 Buy
30206 50mg $435 Buy
30206 100mg $770 Buy

Roquinimex Chemical Properties,Uses,Production

Description

Roquinimex is an immunomodulator with diverse biological activities. In vivo, roquinimex (80 mg/kg) increases the number of myocardial MHC class II-expressing cells, the ratio of cytotoxic to helper T cells, and survival and decreases necrotic lesion area in a mouse model of murine coxsackievirus B3-induced myocarditis. It induces IFN-γ production, reduces TNF-α and IL-1β production, prevents the development of proteinuria, and ameliorates nephritis in a mouse model of chronic graft versus host disease (GVHD). Roquinimex (300 mg/kg) decreases colonic myeloperoxidase (MPO) activity and mucosal damage in a mouse model of colitis induced by dextran sulfate (DSS; ). It also decreases tumor weight and tumor blood flow in a von Hippel-Lindau (VHL) type 2a paraganglioma mouse xenograft model.

Uses

Biological response modifier; immunomodulator.

Uses

An immunomodulator with antitumour properties. Inhibits T-cell apoptosis in vivo; also inhibits angiogenesis in rats

Definition

ChEBI: 4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide is an aromatic amide.

Biological Activity

Immunomodulator with stimulatory and antitumor properties. Inhibits in vivo apoptosis of T-cells and inhibits angiogenesis in rats in vivo .

References

[1] N. ILBCK. Effects of the immunomodulator LS 2616 on lymphocyte subpopulations in murine Coxsackievirus B3 myocarditis.[J]. Journal of immunology, 1989, 142 9 1: 3225-3228. DOI: 10.4049/jimmunol.142.9.3225
[2] ZHI-YONG XIAO. Roquinimex-mediated protection effect on the development of chronic graft-versus-host disease in mice is associated with induction of Th1 cytokine production and inhibition of proinflammatory cytokine production[J]. Life sciences, 2007, 81 19: Pages 1403-1410. DOI: 10.1016/j.lfs.2007.08.044
[3] Q LIU. Roquinimex inhibits dextran sodium sulfate-induced murine colitis.[J]. Inflammation Research, 2003, 52 2: 64-68. DOI: 10.1007/s000110300002
[4] D J GROSS. The antiangiogenic agent linomide inhibits the growth rate of von Hippel-Lindau paraganglioma xenografts to mice.[J]. Clinical Cancer Research, 1999, 5 11: 3669-3675.

Roquinimex synthesis

100-61-8
84088-50-6
84088-42-6
Synthesis of Roquinimex from N-Methylaniline and 3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-, Methyl ester

Roquinimex Preparation Products And Raw materials

Raw materials

3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-Methyl-2-oxo- methyl 3-(N-methyl-N-phenylamino)-3-oxopropanoate 3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-, Methyl ester 1,2-Dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester N-methylisatoic anhydride
Isatoic Anhydride N-Methylaniline Anthranilic acid

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Preparation Products

Roquinimex Suppliers

Global( 129)Suppliers
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
TOKYO CHEMICAL INDUSTRY CO., LTD. 03-36680489 Sales-JP@TCIchemicals.com Japan 28364 80
TCI Europe 320-37350700 sales@tcieurope.eu Europe 23654 75
TCI AMERICA 800-4238616 sales@tciamerica.com Americas 23636 75
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2374 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4861 55
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
TCI (Shanghai) Development Co., Ltd. 81
VDM Biochemicals 64
TOKYO CHEMICAL INDUSTRY CO., LTD. 80
TCI Europe 75
TCI AMERICA 75
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
MedChemexpress LLC 58
LETOPHARM LIMITED 58
Shanghai Lollane Biological Technology Co.,Ltd. 55

View Lastest Price from Roquinimex manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Roquinimex pictures 2026-07-27 Roquinimex
84088-42-6
 $30.00-94.00 99.65% 10g TargetMol Chemicals Inc.
  • Roquinimex pictures
  • Roquinimex
    84088-42-6
  • $30.00-94.00
  • 99.65%
  • TargetMol Chemicals Inc.

Roquinimex Spectrum

Roquinimex(84088-42-6)1HNMR

84088-42-6(Roquinimex)Related Search:

Dimethyl sebacate Dimethyl carbonate Dimethyl phthalate Dihydromyrcenol Dimethyl ether
Dimethyl fumarate Ethane N,N-Dimethylformamide Dimethyl sulfoxide CIVENTICHEM CV-4057
Roquinimex

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N-PHENYLMETHYL-1,2-DIHYDRO-4-HYDROXYL-N,1-DIMETHYL-2-OXO-QUINOLINE-3-CARBOXAMIDE ROQUINIMEX LINOMIDE LS-2616 1,2-DIHYDRO-4-HYDROXY-N,1-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE 1,2-DIHYDRO-4-HYDROXY-N,N-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE CS-1231 Roquinimex(Linomide) 4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide 1,2-Dihydro-4-hydroxy-1,N-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide N,1-Dimethyl-N-phenyl-2-oxo-4-hydroxy-1,2-dihydroquinoline-3-carboxamide PNU 212616 N-phenyl-N-Methyl-1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-quinoline-3-carboxaMide ABR212616 FCF89 3-Quinolinecarboxamide, 1,2-dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl- Tumor Necrosis Factor Receptor,FCF-89,TNF Receptor,TNFR,Roquinimex,Inhibitor,ABR-212616,ABR 212616,FCF 89,inhibit Roquinimex, 10 mM in DMSO 4-hydroxy-N,1-dimethyl-2-oxy-N-phenyl-1,2-dihydroquinoline-3-carboxamide 84088-42-6 C18H16N2O3 Cell Signaling and Neuroscience Cell Biology BioChemical Immune System Regulation Immunomodulators and Antibiotics Immune Cell Signaling and Blood Antitumour