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4-Phenyl-pyridin-2-ylamine

4-Phenyl-pyridin-2-ylamine Structure
4-Phenyl-pyridin-2-ylamine structure
CAS No.
60781-83-1
Chemical Name:
4-Phenyl-pyridin-2-ylamine
Synonyms
4-phenylpyridin-2-amine;4-phenyl-;4-phenyl-2-pyridinamin;4-Phenyl-2-pyridinamine;4-phenyl-2-aminopyridine;2-AMINO-4-PHENYLPYRIDINE;4-Phenylpyridine-2-amine;2-Pyridinamine, 4-phenyl-;4-Phenyl-pyridin-2-ylamine
CBNumber:
CB2415301
Molecular Formula:
C11H10N2
Molecular Weight:
170.21
MDL Number:
MFCD00137848
MOL File:
60781-83-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:51:18
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4-Phenyl-pyridin-2-ylamine Properties

Melting point 164-165 °C(Solv: benzene (71-43-2))
Boiling point 343.7±30.0 °C(Predicted)
Density 1.133±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
form solid
pka 6.63±0.11(Predicted)
color Yellow
EPA Substance Registry System 2-Amino-4-phenylpyridine (60781-83-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Risk Statements  41
Safety Statements  26-39
TSCA  TSCA listed
HS Code  2933399990

4-Phenyl-pyridin-2-ylamine price More Price(60)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 287979 4-Phenyl-pyridin-2-ylamine Asreported 60781-83-1 100mg $373 2026-06-03 Buy
Usbiological 287979 4-Phenyl-pyridin-2-ylamine Asreported 60781-83-1 250mg $478 2026-06-03 Buy
Usbiological 287979 4-Phenyl-pyridin-2-ylamine Asreported 60781-83-1 500mg $644 2026-06-03 Buy
Usbiological 287979 4-Phenyl-pyridin-2-ylamine Asreported 60781-83-1 1g $914 2026-06-03 Buy
Usbiological 287979 4-Phenyl-pyridin-2-ylamine Asreported 60781-83-1 2g $1257 2026-06-03 Buy
Product number Packaging Price Buy
287979 100mg $373 Buy
287979 250mg $478 Buy
287979 500mg $644 Buy
287979 1g $914 Buy
287979 2g $1257 Buy

4-Phenyl-pyridin-2-ylamine Chemical Properties, Uses, Production

Synthesis Reference(s)

Journal of Medicinal Chemistry, 21, p. 874, 1978 DOI: 10.1021/jm00207a007
The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y

Synthesis

2-Amino-4-bromopyridine

84249-14-9

Phenylboronic acid

98-80-6

4-PHENYL-PYRIDIN-2-YLAMINE

60781-83-1

General procedure for the synthesis of 2-amino-4-phenylpyridine from 2-amino-4-bromopyridine and phenylboronic acid: phenylboronic acid (141 mg, 1.156 mmol), 4-bromo-2-amino-pyridine (200 mg, 1.156 mmol) and PdCl2(dppf)-CH2Cl2 adduct (94 mg, 0.116 mmol) were suspended in a mixture of 1,2 -dimethoxyethane (3 mL) and 1 M aqueous sodium carbonate (3.47 mL, 3.47 mmol) in a mixed solvent. The reaction mixture was stirred at 90 °C for 5 h and subsequently cooled to room temperature. The reaction mixture was filtered through a diatomaceous earth pad and the filter cake was washed with dichloromethane (DCM). The filtrate was concentrated under reduced pressure to remove the solvent, and the resulting crude product was purified by silica gel column chromatography (Biotage 40M column) using 0-10% methanol/dichloromethane gradient elution to afford the target product 2-amino-4-phenylpyridine (195 mg, 1.146 mmol, 99% yield). The product structure was confirmed by 1H NMR (400 MHz, CDCl3) and UPLC-MS: 1H NMR δ 4.49 (dd, 2H), 6.69-6.78 (m, 1H), 6.90 (dd, 1H), 7.39-7.52 (m, 3H), 7.56-7.68 (m, 2H), 8.10-8.17 (m, 1H); UPLC-MS: tR = 0.42 min, m/z = 171 [M + H]+.

References

[1] Patent: US2009/203705, 2009, A1. Location in patent: Page/Page column 49
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 24, p. 11171 - 11181
[3] Patent: WO2017/141036, 2017, A1. Location in patent: Page/Page column 50

4-Phenyl-pyridin-2-ylamine Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide Ethyl acetate Hydrochloric acid 5-Ethyl-2-methylpyridine Dichloromethane
Methanol Petroleum ether Sodium amide 2-Amino-4-bromopyridine Phenylboronic acid

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Preparation Products

4-Phenyl-pyridin-2-ylamine Suppliers

Global Suppliers ( 107)
Supplier Tel Email Country ProdList Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Tetranov Biopharm 13526569071 sales@leadmedpharm.com China 7881 64
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Wuhan Luohua Medical Technology Co.,Ltd. 13477084141; 13477084141 sales@luohuapharm.com China 468 60
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
Supplier Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Pure Chemistry Scientific Inc. 62
Tetranov Biopharm 64
Shanghai Longsheng chemical Co.,Ltd. 59
Chemsky（shanghai）International Co.,Ltd. 50
Wuhan Luohua Medical Technology Co.,Ltd. 60
Shanghai Ennopharm Co., Ltd. 65

View Latest Price from 4-Phenyl-pyridin-2-ylamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-PHENYL-PYRIDIN-2-YLAMINE pictures 2020-02-02 4-PHENYL-PYRIDIN-2-YLAMINE
60781-83-1
 $3.00 1KG 98% 100KG Career Henan Chemical Co

4-Phenyl-pyridin-2-ylamine Spectrum

4-PHENYL-PYRIDIN-2-YLAMINE(60781-83-1)1HNMR

60781-83-1 (4-Phenyl-pyridin-2-ylamine) Related Search:

3-Amino-2-phenylpyridine 6-Phenyl-pyridin-2-ylamine 4-Phenylpyridine 3-Amino-4-phenylpyridine 2-(4-Methoxyphenyl)-3-pyridinamine
2-Amino-5-phenylpyridine 4-Phenyl-pyridin-2-ylamine 3-Phenyl-pyridin-2-ylamine 4-Phenyl-pyridin-3-ylamine dihydrochloride 2-Phenyl-pyridin-3-ylamine hydrochloride
2-Amino-4-(4-chlorophenyl)-5-methyl-6-phenylnicotinonitrile 2-Amino-4-(3-chlorophenyl)-6-(4-methoxyphenyl)nicotinonitrile 2-Amino-4-(2-chlorophenyl)-6-isobutylnicotinonitrile 2-Phenyl-pyridin-4-ylamine 2-(4-Trifluoromethyl-phenyl)-pyridin-3-ylamine
6-Phenyl-3-pyridinamine 5-Phenyl-pyridin-3-ylamine 2-Amino-3-bromo-5-phenylpyridine

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2-AMINO-4-PHENYLPYRIDINE 4-phenyl-2-pyridinamin 4-phenyl- 4-phenyl-2-aminopyridine 4-Phenyl-2-pyridinamine 4-Phenylpyridine-2-amine 2-Pyridinamine, 4-phenyl- 4-phenylpyridin-2-amine 4-Phenyl-pyridin-2-ylamine 60781-83-1 API intermediates