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2-Phenyl-pyridin-4-ylamine

2-Phenyl-pyridin-4-ylamine Structure
2-Phenyl-pyridin-4-ylamine structure
CAS No.
21203-86-1
Chemical Name:
2-Phenyl-pyridin-4-ylamine
Synonyms
2-PPA;2-Phenylpyridin-4-aMine;4-AMINO-2-PHENYLPYRIDINE;2-phenyl-4-aminopyridine;4-Pyridinamine, 2-phenyl-;2-Phenyl-pyridin-4-ylamine;Pyridine, 4-amino-2-phenyl-
CBNumber:
CB8370897
Molecular Formula:
C11H10N2
Molecular Weight:
170.21
MDL Number:
MFCD01646280
MOL File:
21203-86-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:42
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2-Phenyl-pyridin-4-ylamine Properties

Boiling point 384.2±30.0 °C(Predicted)
Density 1.133±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 8.22±0.10(Predicted)
form solid
color Pale yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Risk Statements  41
Safety Statements  26-39
HS Code  2933399990

2-Phenyl-pyridin-4-ylamine price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 287994 2-Phenyl-pyridin-4-ylamine Asreported 21203-86-1 50mg $337 2026-06-03 Buy
Usbiological 287994 2-Phenyl-pyridin-4-ylamine Asreported 21203-86-1 100mg $462 2026-06-03 Buy
Usbiological 287994 2-Phenyl-pyridin-4-ylamine Asreported 21203-86-1 250mg $566 2026-06-03 Buy
Usbiological 287994 2-Phenyl-pyridin-4-ylamine Asreported 21203-86-1 500mg $744 2026-06-03 Buy
Usbiological 287994 2-Phenyl-pyridin-4-ylamine Asreported 21203-86-1 1g $1313 2026-06-03 Buy
Product number Packaging Price Buy
287994 50mg $337 Buy
287994 100mg $462 Buy
287994 250mg $566 Buy
287994 500mg $744 Buy
287994 1g $1313 Buy

2-Phenyl-pyridin-4-ylamine Chemical Properties,Uses,Production

Uses

2-PPA is a selective inhibitor of TMEM175 (IC50=32 μM) with activity in modulating lysosomal function. Acute inhibition of TMEM175 by 2-PPA increases lysosomal macromolecular catabolism, thereby accelerating macrophage and other digestive processes. 2-PPA can be used in the study of Parkinson's disease[1].

Synthesis

4-Amino-2-chloropyridine

14432-12-3

Phenylboronic acid

98-80-6

2-PHENYL-PYRIDIN-4-YLAMINE

21203-86-1

a) Synthesis of 2-phenyl-pyridin-4-ylamine: To a stirred solution of 16.0 g (124 mmol) of 2-chloro-4-aminopyridine dissolved in 200 ml of toluene, 18.2 g (149 mmol) of phenylboronic acid, 7.19 g (6.22 mmol) of tetrakis(triphenylphosphine)palladium(0), and 130 ml (260 mmol) of 2M sodium carbonate were added in turn. aqueous solution. The reaction mixture was heated to reflux at 100 °C for 16 h and subsequently cooled to room temperature. The reaction solution was extracted three times with ethyl acetate and the organic phases were combined. The organic phase was washed three times with 200 ml of 1 M hydrochloric acid aqueous solution. The acidic and aqueous phases were combined, adjusted to alkaline with 5 M aqueous sodium hydroxide and extracted three times with dichloromethane. The organic extracts were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by fast column chromatography (eluent: acetone) and subsequently ground in hexane containing a small amount of ether to give 18.5 g (87% yield) of 2-phenyl-pyridin-4-ylamine as a white solid.ES-MS m/e (relative abundance): 171 ([M+H]+, 100).

References

[1] SeCheol, et al. "Discovery of Selective Inhibitors for the Lysosomal Parkinson’s Disease Channel TMEM175." Journal of the American Chemical Society (2024). DOI:10.1021/jacs.4c05623

2-Phenyl-pyridin-4-ylamine Preparation Products And Raw materials

Raw materials

4-Amino-2-chloropyridine 2-Amino-4-chloropyridine 4-Amino-2-bromopyridine Phenylboronic acid Sodium carbonate
Toluene

1of2

Preparation Products

2-Phenyl-pyridin-4-ylamine Suppliers

Global( 76)Suppliers
Supplier Tel Email Country ProdList Advantage
Tetranov Biopharm 13526569071 sales@leadmedpharm.com China 7881 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Shanghai yirong biology science and technology co., ltd 18049974220 3060526242@qq.com China 999 60
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 85114309 18982182443 yangli@happysyn.com China 2283 55
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
SynAsst Chemical. 021-60343070 China 12731 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
NovoChemy Ltd. 86-(0)21-31261262 373522135 sales@novochemy.com China 6491 58
Supplier Advantage
Tetranov Biopharm 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
Shanghai yirong biology science and technology co., ltd 60
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 55
Shanghai Topbiochem Technology Co., Ltd 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
SynAsst Chemical. 55
Bide Pharmatech Ltd. 60
NovoChemy Ltd. 58

View Lastest Price from 2-Phenyl-pyridin-4-ylamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-PHENYL-PYRIDIN-4-YLAMINE pictures 2019-07-06 2-PHENYL-PYRIDIN-4-YLAMINE
21203-86-1
 $1.00 1KG 95% 500KG Career Henan Chemical Co

2-Phenyl-pyridin-4-ylamine Spectrum

2-PHENYL-PYRIDIN-4-YLAMINE(21203-86-1)1HNMR

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4-AMINO-2-PHENYLPYRIDINE Pyridine, 4-amino-2-phenyl- 4-Pyridinamine, 2-phenyl- 2-phenyl-4-aminopyridine 2-Phenylpyridin-4-aMine 2-PPA 2-Phenyl-pyridin-4-ylamine 21203-86-1 API intermediates