3-Amino-2-phenylpyridine
- CAS No.
- 101601-80-3
- Chemical Name:
- 3-Amino-2-phenylpyridine
- Synonyms
- Abametapir Impurity 6;2-Phenylpyridin-3-amine;2-PHENYL-3-PYRIDINAMINE;3-Amino-2-phenylpyridine;2-phenyl-3-aminopyridine;3-Pyridinamine, 2-phenyl-;2-PHENYL-PYRIDIN-3-YLAMINE;3-AMINO-2-PHENYLPYRIDINE ISO 9001：2015 REACH;2-Phenylpyridin-3-amine, (3-Aminopyridin-2-yl)benzene
- CBNumber:
- CB0483793
- Molecular Formula:
- C11H10N2
- Molecular Weight:
- 170.21
- MDL Number:
- MFCD04114113
- MOL File:
- 101601-80-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | Xi |
| Hazard Note | Irritant |
| HS Code | 2933399990 |
3-Amino-2-phenylpyridine price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 231552 | 3-Amino-2-phenylpyridine | 101601-80-3 | 250mg | $200 | 2026-06-03 | Buy |
| Usbiological | 231552 | 3-Amino-2-phenylpyridine | 101601-80-3 | 1g | $259 | 2026-06-03 | Buy |
| Usbiological | 231552 | 3-Amino-2-phenylpyridine | 101601-80-3 | 5g | $645 | 2026-06-03 | Buy |
| Usbiological | 231552 | 3-Amino-2-phenylpyridine | 101601-80-3 | 10g | $1120 | 2026-06-03 | Buy |
| Activate Scientific | AS49705 | 2-Phenylpyridin-3-amine 95% | 101601-80-3 | 1g | $99 | 2026-06-04 | Buy |
3-Amino-2-phenylpyridine Chemical Properties,Uses,Production
Uses
3-Amino-2-phenylpyridine is arylpyridine building block that can be prepared using palladium charcoal-catalyzed Suzuki-Miyaura coupling using halopyridinamine and phenylboronic acid as starting materials.
Synthesis
6298-19-7
98-80-6
101601-80-3
General procedure for the synthesis of 2-phenyl-3-aminopyridine from 3-amino-2-chloropyridine and phenylboronic acid: palladium acetate (224.5 mg, 1.00 mmol) and triphenylphosphine (1.05 g, 4.00 mmol) were dissolved in toluene (1000 mL) and stirred for 15 min at room temperature. Subsequently, phenylboronic acid (114 g, 935 mmol), 2-chloro-3-aminopyridine (100 g, 778 mmol), benzaldehyde (83.4 g, 786 mmol) and additional toluene (500 mL) were added to the reaction system. Next, a solution prepared from sodium carbonate (200 g, 1.89 mol) dissolved in water (1500 mL) was added. The reaction mixture was heated to reflux and maintained for 18 hours and then cooled to room temperature. Upon completion of the reaction, the organic and aqueous layers were separated. The organic layer was washed with water (500 mL) and subsequently acidified by adding 2.5 M aqueous hydrochloric acid (630 mL). The aqueous layer was separated and washed with toluene (300 mL). The pH of the aqueous layer was adjusted to 12-13 using 50% aqueous sodium hydroxide, followed by extraction with methyl tert-butyl ether (500 mL). The organic layers were combined, concentrated and the target product 2-phenyl-3-aminopyridine (128 g, 97% yield) was obtained by crystallization from diisopropyl ether. The melting point was determined to be 67-68 °C. 1H NMR (300 MHz, CDCl3) δ 3.88 (broad peak, 2H), 7.02-7.11 (multiple peaks, 2H), 7.28-7.53 (multiple peaks, 3H), 7.67-7.71 (multiple peaks, 2H), 8.13-8.16 (multiple peaks, 1H). 13C NMR (100 MHz. CDCl3) δ 122.57, 122.96, 128.14, 128.38, 128.72, 138.54, 139.86, 139.93, 144.93.
References
[1] Journal of Organic Chemistry, 2003, vol. 68, # 24, p. 9412 - 9415
[2] Patent: US6316632, 2001, B1
[3] European Journal of Organic Chemistry, 2012, # 31, p. 6248 - 6259,12
[4] European Journal of Organic Chemistry, 2012, # 31, p. 6248 - 6259
[5] Tetrahedron Letters, 2005, vol. 46, # 20, p. 3573 - 3577
3-Amino-2-phenylpyridine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7882 | 64 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2283 | 58 |
| Shanghai Hong-chuang Pharma Tech Co., Ltd. | 18151128828 | hc-sales@foxmail.com | China | 2635 | 55 |
View Lastest Price from 3-Amino-2-phenylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-25 | 3-AMINO-2-PHENYLPYRIDINE
101601-80-3
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd |
-
- 3-AMINO-2-PHENYLPYRIDINE
101601-80-3
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
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