4-Chloro-2-iodoaniline
- CAS No.
- 63069-48-7
- Chemical Name:
- 4-Chloro-2-iodoaniline
- Synonyms
- oro-2-iodoaniL;4-Chloro-2-iodoanili;4-CHLORO-2-IODOANILINE;2-IODO-4-CHLOROANILINE;4-Chloro-2-lodoaniline;4-ChIoro-2-Iodoaniline;p-chloro-o-iodoaniline;4-Chloro-2-iodoanilineE;2-iodine-4-chloroaniline;4-CHLORO-2-IODOANILINE 98%
- CBNumber:
- CB2475288
- Molecular Formula:
- C6H5ClIN
- Molecular Weight:
- 253.47
- MDL Number:
- MFCD01863737
- MOL File:
- 63069-48-7.mol
- MSDS File:
- SDS
| Melting point | 40 °C |
|---|---|
| Boiling point | 295.0±25.0 °C(Predicted) |
| Density | 2.015±0.06 g/cm3(Predicted) |
| Flash point | >110 °C |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | soluble in Methanol |
| form | Powder |
| pka | 1.90±0.10(Predicted) |
| color | White to off-white |
| Sensitive | Light Sensitive |
| InChI | InChI=1S/C6H5ClIN/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2 |
| InChIKey | FLEJOBRWKBPUOX-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=C(Cl)C=C1I |
| CAS DataBase Reference | 63069-48-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H318-H335 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P310-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | Xi,N,T | |||||||||
| Risk Statements | 20/21/22-36/37/38-51/53-41-37/38-25 | |||||||||
| Safety Statements | 26-36/37/39-61-45 | |||||||||
| RIDADR | UN 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214200 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
4-Chloro-2-iodoaniline price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 516139 | 4-Chloro-2-iodoaniline 98% | 63069-48-7 | 5g | $65.6 | 2026-04-30 | Buy |
| TCI Chemical | C1800 | 4-Chloro-2-iodoaniline >98.0%(GC) | 63069-48-7 | 5g | $92 | 2026-04-30 | Buy |
| TCI Chemical | C1800 | 4-Chloro-2-iodoaniline >98.0%(GC) | 63069-48-7 | 25g | $290 | 2026-04-30 | Buy |
| Strem Chemicals | 07-0064 | 4-Chloro-2-iodoaniline, min. 98% min.98% | 63069-48-7 | 25g | $73 | 2026-04-30 | Buy |
| Strem Chemicals | 07-0064 | 4-Chloro-2-iodoaniline, min. 98% min.98% | 63069-48-7 | 100g | $185 | 2026-04-30 | Buy |
4-Chloro-2-iodoaniline Chemical Properties, Uses, Production
Uses
Iodinated aminoaryl compounds such as 2-iodo-4-chloroaniline are of considerable value as synthetic intermediates and can be used in a variety of industrial environments, including the pharmaceutical industry.
Chemical Properties
Pale brown to purple low melting solid
Synthesis
106-47-8
63069-48-7
88149-53-5
General method: 4-Chloroaniline (20.0 mmol) was dissolved in a solvent mixture of H2O (100 mL) and MeOH (300 mL) and the pH was adjusted to 1-2 by adding concentrated HCl (tested using pH paper). Subsequently, NaICl2 aqueous solution (50% w/w, 1.1-4.8 molar equivalents, see table for exact dosage) was slowly added dropwise and the reaction mixture was stirred for 3-4 hours at room temperature. Upon completion of the reaction, the reaction was quenched by adding saturated NaHSO3 aqueous solution until the starch test was negative. If no significant precipitate was generated in the reaction mixture, the pH was adjusted to alkaline by dropwise addition of 1 M NaOH aqueous solution (tested using pH paper), followed by extraction with Et2O. The organic phases were combined, dried with MgSO4, filtered and concentrated under reduced pressure to give the solid product. If a precipitate was generated in the reaction mixture, the solid was first separated by gravity filtration, then the filtrate was adjusted to slightly basic (using 1 M NaOH aqueous solution) and extracted with Et2O. The organic extracts were combined, dried with MgSO4, filtered and concentrated under reduced pressure to give the solid product. All solid products were analyzed by TLC (silica gel plates, different ratios of hexane/ethyl acetate as unfolding agent). If the products were mixtures, they were separated and purified by fast column chromatography (silica gel, hexane/ethyl acetate = 9:1, unless otherwise stated). The final products were characterized by melting point (compared to literature values), IR, MS, 1H-NMR, 13C-NMR spectra and elemental analysis (for new compounds). It should be noted that the reaction products of anilines 1a-1j are mostly known compounds, while theanisidines failed to yield characterizable products.
References
[1] Organic Preparations and Procedures International, 2016, vol. 48, # 5, p. 385 - 392
[2] Synlett, 2014, vol. 25, # 6, p. 831 - 834
4-Chloro-2-iodoaniline Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Hanxuan Biotechnology Co., Ltd | 18602598900，18605190599 18602598900 | 1669093670@qq.com | China | 95 | 58 |
| Anhui Jianzhu Biotechnology Co., Ltd. | 15855184105 | 3150278607@qq.com | China | 64 | 58 |
| Suzhou Haihe Pharmaceutical Technology Co., Ltd. | 13816002113 | 68249111@qq.com | China | 51 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from 4-Chloro-2-iodoaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 4-Chloro-2-iodoaniline
63069-48-7
|
$1.00-50.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 4-Chloro-2-iodoaniline
63069-48-7
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2023-10-22 | 4-Chloro-2-iodoaniline
63069-48-7
|
1drums | 99%min. | 10tons | Shanghai Xinchem Co., Ltd. |
-
- 4-Chloro-2-iodoaniline
63069-48-7
- $1.00-50.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Chloro-2-iodoaniline
63069-48-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4-Chloro-2-iodoaniline
63069-48-7
- 99%min.
- Shanghai Xinchem Co., Ltd.
