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ChemicalBook >> CAS DataBase List >>6-chloro-1H-indazol-3-amine

6-chloro-1H-indazol-3-amine

6-chloro-1H-indazol-3-amine Structure
6-chloro-1H-indazol-3-amine structure
CAS No.
16889-21-7
Chemical Name:
6-chloro-1H-indazol-3-amine
Synonyms
Zinc00154498;Einecs 240-925-9;6-chloro-1H-indazol-3-amine;3-Amino-6-chloro-1H-indazole;1H-Indazol-3-amine, 6-chloro-;6-chloro-1H-indoleazole-3-amine;6-Chloro-1H-Indazol-3-Amine (6-Chloro-1H-Indazol-3-Yl)Amine
CBNumber:
CB7932205
Molecular Formula:
C7H6ClN3
Molecular Weight:
167.6
MDL Number:
MFCD00047207
MOL File:
16889-21-7.mol
MSDS File:
SDS
Last updated:2026-05-28 02:56:32
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6-chloro-1H-indazol-3-amine Properties

Boiling point 408.7±25.0 °C(Predicted)
Density 1.533±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
pka 13.72±0.40(Predicted)
Appearance Off-white to pale purple Solid
InChI InChI=1S/C7H6ClN3/c8-4-1-2-5-6(3-4)10-11-7(5)9/h1-3H,(H3,9,10,11)
InChIKey BPTYMRSBTUERSW-UHFFFAOYSA-N
SMILES N1C2=C(C=CC(Cl)=C2)C(N)=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

6-chloro-1H-indazol-3-amine price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth C-4160 6-Chloro-1H-indazol-3-amine 16889-21-7 10g $262.4 2026-06-04 Buy
Biosynth C-4160 6-Chloro-1H-indazol-3-amine 16889-21-7 25g $570.25 2026-06-04 Buy
Biosynth C-4160 6-Chloro-1H-indazol-3-amine 16889-21-7 50g $991.5 2026-06-04 Buy
Biosynth C-4160 6-Chloro-1H-indazol-3-amine 16889-21-7 100g $1724 2026-06-04 Buy
Biosynth C-4160 6-Chloro-1H-indazol-3-amine 16889-21-7 250g $3745 2026-06-04 Buy
Product number Packaging Price Buy
C-4160 10g $262.4 Buy
C-4160 25g $570.25 Buy
C-4160 50g $991.5 Buy
C-4160 100g $1724 Buy
C-4160 250g $3745 Buy

6-chloro-1H-indazol-3-amine Chemical Properties,Uses,Production

Uses

Starting from 6-chloro-1H-indazol-3-amine, the EDC/HOAt promoted coupling with the (S)-carboxylic acid derivative furnished (S)-1-(3-Amino-6-chloro-1H-indazol-1-yl)-2-methyl-3-phenoxypro-pan-1-one. This synthesis was performed to explore the structure-activity relationships (SAR) by substituting the indazole scaffold at the 6-position with a chlorine atom, facilitating the identification of novel CFTR potentiators.[1]

References

[1] Liu, F., Kaplan, A. L., Levring, J., Einsiedel, J., Tiedt, S., Distler, K., Omattage, N. S., Kondratov, I. S., Moroz, Y. S., Pietz, H. L., Irwin, J. J., Gmeiner, P., Shoichet, B. K., & Chen, J. (2024). Structure-based discovery of CFTR potentiators and inhibitors. Cell, 42 1. https://doi.org/10.1016/j.cell.2024.04.046

6-chloro-1H-indazol-3-amine synthesis

63069-48-7
16889-21-7
Synthesis of 6-chloro-1H-indazol-3-amine from 4-Chloro-2-iodoaniline

6-chloro-1H-indazol-3-amine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide N-Methyl-2-pyrrolidone Hydrazine hydrate Thionyl chloride 2,4-Dichlorobenzoic acid
4-Chloro-2-iodoaniline Benzonitrile, 2-broMo-4-hydrazinyl- 2-Chloro-4-hydrazinylbenzonitrile(WX191485) 2-Bromo-4-chlorobenzonitrile 2-Bromo-4-chlorobenzamide
4-Chloro-2-fluorobenzonitrile 2,4-Dichlorobenzonitrile

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Preparation Products

6-chloro-1H-indazol-3-amine Suppliers

Global( 58)Suppliers
Supplier Tel Email Country ProdList Advantage
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Xi’an chemsoar Medical Technology Co., ltd 029-86538357 China 234 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Shanghai Jian Chao Chemical Technology Co., Ltd. 150-2103-5486 18017383231 983544897@qq.com China 9336 55
SuZhou ShiYa Biopharmaceuticals, Inc. 86(512)5235 8471 17715136450 sales@shiyabiopharm.com China 4167 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
Shanghai ChriChem Co., Ltd. 021-54880687 China 510 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 14982 55
Accela ChemBio Inc. +1(858) 699-3322 marketing@accelachem.com United States 6022 65
Supplier Advantage
Accela ChemBio Co.,Ltd. 64
Xi’an chemsoar Medical Technology Co., ltd 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Shanghai Jian Chao Chemical Technology Co., Ltd. 55
SuZhou ShiYa Biopharmaceuticals, Inc. 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Shanghai ChriChem Co., Ltd. 55
Bide Pharmatech Ltd. 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55
Accela ChemBio Inc. 65

6-chloro-1H-indazol-3-amine Spectrum

6-chloro-1H-indazol-3-amine(16889-21-7)1HNMR

16889-21-7(6-chloro-1H-indazol-3-amine)Related Search:

(3-Amino-5-nitrophenyl)methanol 5-Chloro-1H-indazol-3-ylamine 3-Amino-4-cyanopyridine 2-Chloro-5-iodo-pyridin-3-ylamine 3-Amino-4-methoxypyridine
3-Amino-6-bromopyrazine-2-carbonitrile 2-Chloro-5-(trifluoromethyl)-3-pyridinamine 3-Amino-6-iodopyrazine-2-carboxylic acid methyl ester 3-Amino-3-(4-cyanophenyl)propanoic acid 3-Pyridinamine, 6-(1-methylethyl)-
3-Amino-5-hydroxybenzoic acid 3-Amino-6-morpholin-4-ylpyridazine 3-aMino-5-broMo-4-chloropyridine 3-Amino-6-trifluoromethyl-pyridin-2-ol 3-amino-6-chloropyrazine-2-carboxylic acid
3-Amino-5-chloropyridin-2-ol HCl (3-aminopyrazin-2-yl)methanol 3-Amino-3-(4-methoxyphenyl)propionic acid

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6-Chloro-1H-Indazol-3-Amine (6-Chloro-1H-Indazol-3-Yl)Amine Zinc00154498 6-chloro-1H-indazol-3-amine Einecs 240-925-9 3-Amino-6-chloro-1H-indazole 1H-Indazol-3-amine, 6-chloro- 6-chloro-1H-indoleazole-3-amine 16889-21-7