NBI 27914 hydrochloride
- CAS No.
- 1215766-76-9
- Chemical Name:
- NBI 27914 hydrochloride
- Synonyms
- NBI 27914 hydrochloride,NBI27914 hydrochloride;4,6-Pyrimidinediamine, 5-chloro-N4-(cyclopropylmethyl)-2-methyl-N4-propyl-N6-(2,4,6-trichlorophenyl)-, hydrochloride (1:1)
- CBNumber:
- CB24806437
- Molecular Formula:
- C18H20Cl4N4.ClH
- Molecular Weight:
- 470.65
- MDL Number:
- MFCD03791321
- MOL File:
- 1215766-76-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
NBI 27914 hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 460604 | NBI 27914 Hydrochloride | 1215766-76-9 | 1mg | $368 | 2026-06-03 | Buy |
| Usbiological | 460604 | NBI 27914 Hydrochloride | 1215766-76-9 | 2.5mg | $566 | 2026-06-03 | Buy |
| Usbiological | 255950 | NBI 27914 hydrochloride Asreported | 1215766-76-9 | 10mg | $423 | 2026-06-03 | Buy |
| Usbiological | 255950 | NBI 27914 hydrochloride Asreported | 1215766-76-9 | 50mg | $1103 | 2026-06-03 | Buy |
| Biosynth | QYB76676 | Nbi 27914 hydrochloride | 1215766-76-9 | 10mg | $545.6 | 2026-06-04 | Buy |
NBI 27914 hydrochloride Chemical Properties, Uses, Production
Uses
NBI 27914 Hydrochloride is a selective non-peptide corticotropin-releasing factor 1 (CRF1) antagonist. Shown to block behavioral seizures in vivo.
in vivo
NBI 27914 (3~30 mg/kg; i.p.) hydrochloride attenuates the referred abdominal pain at the highest dose tested, it is efficacious both 4 and 24 h post-indomethacin dosing[1].
NBI 27914 (1~10 mg/kg; i.p.) hydrochloride dose dependently attenuates Freund's Complete Adjuvant-induced mechanical hyperalgesia. NBI 27914 (10 mg/kg) hydrochloride reverses the thermal hyperalgesia. NBI 27914 hydrochloride attenuates spinal nerve ligation-induced mechanical hyperalgesia and tactile allodynia with minimal effective doses equal to 5 and 10 mg/kg, respectively[1]. The higher doses of NBI 27914 hydrochloride blocks the behavioral seizures and prevents epileptic discharges in concurrent electroencephalograms recorded from the amygdala[2].
| Animal Model: | Male CD-1 mice (20~25 g)[1] |
| Dosage: | 3~30 mg/kg |
| Administration: | I.p. |
| Result: | Attenuated the referred abdominal pain at the highest dose tested, it was efficacious both 4 and 24 h post-indomethacin dosing. |
IC 50
CRFR1
storage
Store at RT
NBI 27914 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
NBI 27914 hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2994 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 5000 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50068 | 58 |
View Latest Price from NBI 27914 hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | NBI-27914 hydrochloride
1215766-76-9
|
$783.00 | 10g | TargetMol Chemicals Inc. |
-
- NBI-27914 hydrochloride
1215766-76-9
- $783.00
- TargetMol Chemicals Inc.
