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Oxaceprol

Oxaceprol Structure
Oxaceprol structure
CAS No.
33996-33-7
Chemical Name:
Oxaceprol
Synonyms
(2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;AC-HYP-OH;N-ACETYL-L-HYDROXYPROLINE;TRANS-1-ACETYL-4-HYDROXY-L-PROLINE;NAHP;CO-61;AHP-200;Jonctum;Ac-L-Hyp;OXACEPROL
CBNumber:
CB2482503
Molecular Formula:
C7H11NO4
Molecular Weight:
173.17
MDL Number:
MFCD00037339
MOL File:
33996-33-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-12 09:13:37
Product description Number Pack Size Price
trans-1-Acetyl-4-hydroxy-L-proline ≥98% 441562 10g $187
AC-HYP-OH 95% AB1252 25G $59
AC-HYP-OH 95% AB1252 100G $179
Acetyl-L-trans-4-hydroxyproline ≥95%(TLC) 02614 1G $63.98
Acetyl-L-trans-4-hydroxyproline ≥95%(TLC) 02614 5G $218.33
More product size
Request For Quotation

Oxaceprol Properties

Melting point 132-133 °C (dec.)(lit.)
alpha -119 º (c=4 in H2O)
Boiling point 303.8°C (rough estimate)
Density 1.3346 (rough estimate)
vapor pressure 0Pa at 20℃
refractive index 1.4490 (estimate)
storage temp. Sealed in dry,2-8°C
solubility DMSO : ≥ 32 mg/mL (184.79 mM)
pka 3.48±0.40(Predicted)
form Crystalline Powder
color White
optical activity [α]20/D 119°, c = 4 in H2O
Merck 14,6903
BRN 84043
Major Application peptide synthesis
Cosmetics Ingredients Functions HUMECTANT
SKIN PROTECTING
SKIN CONDITIONING
SKIN CONDITIONING - EMOLLIENT
HAIR CONDITIONING
InChI 1S/C7H11NO4/c1-4(9)8-3-5(10)2-6(8)7(11)12/h5-6,10H,2-3H2,1H3,(H,11,12)/t5-,6+/m1/s1
InChIKey BAPRUDZDYCKSOQ-RITPCOANSA-N
SMILES CC(=O)N1C[C@H](O)C[C@H]1C(O)=O
LogP -1.51 at 20℃
CAS DataBase Reference 33996-33-7(CAS DataBase Reference)
FDA UNII Q0XV76B96L
ATC code D11AX09,M01AX24
EPA Substance Registry System L-Proline, 1-acetyl-4-hydroxy-, (4R)- (33996-33-7)
UNSPSC Code 12352209
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H318
Precautionary statements  P280-P305+P351+P338
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  41
Safety Statements  26-36
WGK Germany  3
F  10
TSCA  TSCA listed
HS Code  29339900
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Dam. 1
REACH Registrations Inactive
NFPA 704
1
2 0

Oxaceprol price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 441562 trans-1-Acetyl-4-hydroxy-L-proline ≥98% 33996-33-7 10g $187 2026-04-30 Buy
AstaTech AB1252 AC-HYP-OH 95% 33996-33-7 25G $59 2026-04-30 Buy
AstaTech AB1252 AC-HYP-OH 95% 33996-33-7 100G $179 2026-04-30 Buy
Chem-Impex 02614 Acetyl-L-trans-4-hydroxyproline ≥95%(TLC) 33996-33-7 1G $63.98 2026-05-19 Buy
Chem-Impex 02614 Acetyl-L-trans-4-hydroxyproline ≥95%(TLC) 33996-33-7 5G $218.33 2026-05-19 Buy
Product number Packaging Price Buy
441562 10g $187 Buy
AB1252 25G $59 Buy
AB1252 100G $179 Buy
02614 1G $63.98 Buy
02614 5G $218.33 Buy

Oxaceprol Chemical Properties,Uses,Production

Chemical Properties

White powder

Originator

Jonctum,Merrell,France,1970

Uses

trans-1-Acetyl-4-hydroxy-L-proline can be used:

  • In the stereospecific synthesis of 4-fluoroglutamic acid.
  • To synthesize molecular targets for von Hippel-Lindau (VHL) E3 ubiquitin ligase.
  • As a precursor to synthesize pseudopoly(amino acids) such as poly(trans-4-hydroxy-4-acyl-L-proline ester) and a biodegradable polymer, poly(lactic acid-glycolic acid-4-hydroxyproline).

Manufacturing Process

16.7 g (0.127 mol) of L-hydroxyproline are dissolved in 400 ml of pure boiling acetic acid. With vigorous boiling and agitation, a mixture of 13.7 ml (0.154 mol) of rectified acetic anhydride and 250 ml of pure acetic acid is added during 25 minutes. Without discontinuing the stirring, contents of the flask are cooled by simply causing fresh air to circulate externally round the flask until the temperature of the mixture is reduced to about 35°C. The acetic acid is removed by using a rotary evaporator without exceeding 35°C under a vacuum of about 15 mm Hg. After one hour, 20 ml of anhydrous toluene are added, then 10 ml of anhydrous acetone; the mixture is homogenized and concentrated again as above during 30 minutes. Then 25 ml of acetone are added again, and subsequently 20 ml of toluene, the product being concentrated again; gradually the solution is converted into an amber-colored crystallized paste. Finally, 30 ml of acetone are added to the residue, and stirring is carried out until the oily fraction surrounding the crystals is dissolved. The product is then cooled in an ice chamber, centrifuged, washed with anhydrous acetone and eventually dried, After recrystallization from acetone, crystals are obtained, melting point 132°C.

Therapeutic Function

Antirheumatic

Flammability and Explosibility

Not classified

reaction suitability

reaction type: solution phase peptide synthesis

Oxaceprol synthesis

108-24-7
51-35-4
33996-33-7
Synthesis of Oxaceprol from Acetic anhydride and L-Hydroxyproline

Oxaceprol Preparation Products And Raw materials

Raw materials

L-Hydroxyproline Acetic anhydride

Preparation Products

2-Oxa-5-azabicyclo[2.2.1]heptan-3-one, 5-acetyl-, (1R,4R)- (9CI)

Oxaceprol Suppliers

Global( 292)Suppliers
Supplier Tel Email Country ProdList Advantage
DONBOO AMINO ACID COMPANY
+8618051385538 donboo@donboo.com China 9363 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 997 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883 niki@zlchemi.com China 7245 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21588 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29816 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10404 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8615060885618 sales@amoychem.com China 6366 58
Supplier Advantage
DONBOO AMINO ACID COMPANY
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shaanxi Haibo Biotechnology Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Xiamen AmoyChem Co., Ltd 		58

Related articles

View Lastest Price from Oxaceprol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Acetyl-L-hydroxyproline pictures 2026-05-23 N-Acetyl-L-hydroxyproline
33996-33-7
 US $0.00 / Kg/Drum 1KG 98%min 500kgs WUHAN FORTUNA CHEMICAL CO., LTD
Oxaceprol pictures 2026-04-22 Oxaceprol
33996-33-7
 US $29.00 / mL 99.32% 10g TargetMol Chemicals Inc.
Oxaceprol pictures 2026-03-20 Oxaceprol
33996-33-7
 US $10.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
  • Oxaceprol pictures
  • Oxaceprol
    33996-33-7
  • US $29.00 / mL
  • 99.32%
  • TargetMol Chemicals Inc.
  • Oxaceprol pictures
  • Oxaceprol
    33996-33-7
  • US $10.00 / KG
  • 99%
  • Hebei Chuanghai Biotechnology Co., Ltd

Oxaceprol Spectrum

Oxaceprol(33996-33-7)MSOxaceprol(33996-33-7)1HNMROxaceprol(33996-33-7)IR1Oxaceprol(33996-33-7)IR2

33996-33-7(Oxaceprol)Related Search:

Oxaceprol TRANS-1-BENZOYL-4-HYDROXY-L-PROLINE METHYL ESTER N-Tetradecanoyl-4-hydroxy-L-proline TRANS-1-BENZOYL-4-HYDROXY-L-PROLINE Dipalmitoyl hydroxyproline
N-Acetyl-L-Hydroxyproline L-Hydroxyproline L-Proline 1-(4-FLUOROBENZOYL)-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID H-GLY-ALA-HYP-OH
H-GLY-PRO-HYP-OH H-PRO-HYP-OH H-GLY-HYP-OH GLY-PRO-HYDROXY-PRO ACETATE SALT 1-(2-FURYLCARBONYL)-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID
METHYL 1-(4-FLUOROBENZOYL)-4-HYDROXY-2-PYRROLIDINECARBOXYLATE Z-PRO-HYP-OH O-acetyl-L-hydroxyproline homopolymer,POLY-O-ACETYL-L-HYDROXYPROLINE)

1of4

N-ACETYLHYDROXY-L-PROLINE N-ALPHA-ACETYL-TRANS-4-HYROXY-L-PYROLLIDINE N-ALPHA-ACETYL-L-4-TRANS-HYDROXYPROLINE N-ALPHA-ACETYL-L-HYROXYPROLINE (-)-1-Acetyl-4β-hydroxy-L-proline (4R)-1-Acetyl-4-hydroxy-L-proline trans-1-Acetyl-4-hydroxy-L-proline 99% trans-1-Acetyl-4-hydroxy-L-proline, >=98% Ac-Hyp-OH≥ 95% (TLC) Nα-Acetyl-L-4-trans-hydroxyproline trans-1-Acetyl-4-hydroxy-L-proline Ac-L-Hyp (4R,2S)-1-ACETYL-4-HYDROXY-PYRROLIDINE-2-CARBOXYLIC ACID ACETYL-L-4-HYDROXYPROLINE ACETYL-4-HYDROXY-L-PROLINE AC-HYDROXYPROLINE OXACEPROL N-ACETYL-4-HYDROXY-L-PROLINE N-AC-L-HYP trans-l-prolin (R)-N-Acetyl-4-hydroxy-L-proline N-Acetyl-4-hydroxyproline N-Acetylhydroxyproline N-Acetyl-trans-4-hydroxy-L-proline AHP-200 CO-61 Jonctum N-Acetyl-L-hydroxyproline;trans-1-Acetyl-4-hydroxy-L-proline;1-Acetyl-4-hydroxy-2-pyrrolidinecarboxylic acid;AHP-200;CO-61;Jonctum;Oxaceprol 1-Acetyl-4-hydroxy-2-pyrrolidinecarboxylic acid Oxaceprol (trans-1-Acetyl-4-hydroxy-L-proline,monhydrate) Acetyl-trans-4-hydroxy-L-proline Hyp4001Ac-Hyp-Oh L-Proline, 1-acetyl-4-hydroxy-, (4R)- (9CI) (2S,4R)-N-ACETYL-4-HYDROXY-L-PROLINE N-Acetyl-L- 4-Hydroxyproline (2S,4R)-1-Acetyl-4-hydroxypyrrolidine-2-carboxylic acid Ac-L-Hyp-OH N-alpha-Acetyl-L-4-hydroxyproline N-Acetyl-L-Hydroproline L-Proline, 1-acetyl-4-hydroxy-, (4R)- Oxaceprol USP/EP/BP OxaceprolQ: What is Oxaceprol Q: What is the CAS Number of Oxaceprol Q: What is the storage condition of Oxaceprol Q: What are the applications of Oxaceprol trans< NAHP Oxaceprol (N-acetyl-L-hydroxyproline) Oxaceprol, 10 mM in DMSO TRANS-1-ACETYL-4-HYDROXY-L-PROLINE N-ACETYL-L-HYDROXYPROLINE AC-HYP-OH (2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID 33996-33-7 33966-33-7 33996-33-8 C7H11NO4 Peptide Synthesis Proline Derivatives Specialty Synthesis Unnatural Amino Acid Derivatives