Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Oxaceprol

Oxaceprol

Oxaceprol Structure
Oxaceprol structure
CAS No.
33996-33-7
Chemical Name:
Oxaceprol
Synonyms
(2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;N-ACETYL-L-HYDROXYPROLINE;NAHP;AC-HYP-OH;TRANS-1-ACETYL-4-HYDROXY-L-PROLINE;(2S,4R)-1-Acetyl-4-hydroxypyrrolidine-2-carboxylic acid;CO-61;AHP-200;Jonctum;Ac-L-Hyp
CBNumber:
CB2482503
Molecular Formula:
C7H11NO4
Molecular Weight:
173.17
MDL Number:
MFCD00037339
MOL File:
33996-33-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-03 18:06:58
Request For Quotation

Oxaceprol Properties

Melting point 132-133 °C (dec.)(lit.)
alpha -119 º (c=4 in H2O)
Boiling point 303.8°C (rough estimate)
Density 1.3346 (rough estimate)
vapor pressure 0Pa at 20℃
refractive index 1.4490 (estimate)
storage temp. Sealed in dry,2-8°C
solubility DMSO : ≥ 32 mg/mL (184.79 mM)
pka 3.48±0.40(Predicted)
form Crystalline Powder
color White
optical activity [α]20/D 119°, c = 4 in H2O
Merck 14,6903
BRN 84043
Major Application peptide synthesis
Cosmetics Ingredients Functions HUMECTANT
SKIN PROTECTING
SKIN CONDITIONING
SKIN CONDITIONING - EMOLLIENT
HAIR CONDITIONING
InChI 1S/C7H11NO4/c1-4(9)8-3-5(10)2-6(8)7(11)12/h5-6,10H,2-3H2,1H3,(H,11,12)/t5-,6+/m1/s1
InChIKey BAPRUDZDYCKSOQ-RITPCOANSA-N
SMILES CC(=O)N1C[C@H](O)C[C@H]1C(O)=O
LogP -1.51 at 20℃
CAS DataBase Reference 33996-33-7(CAS DataBase Reference)
FDA UNII Q0XV76B96L
ATC code D11AX09,M01AX24
EPA Substance Registry System L-Proline, 1-acetyl-4-hydroxy-, (4R)- (33996-33-7)
UNSPSC Code 12352209
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H318
Precautionary statements  P280-P305+P351+P338
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  41
Safety Statements  26-36
WGK Germany  3
F  10
TSCA  TSCA listed
HS Code  29339900
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Dam. 1
REACH Registrations Inactive
NFPA 704
1
2 0

Oxaceprol price More Price(58)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 441562 trans-1-Acetyl-4-hydroxy-L-proline ≥98% 33996-33-7 10g $187 2026-04-30 Buy
Usbiological 260538 Acetyl-L-4-hydroxyproline Asreported 33996-33-7 50g $326 2026-06-03 Buy
Usbiological 260538 Acetyl-L-4-hydroxyproline Asreported 33996-33-7 100g $432 2026-06-03 Buy
Usbiological 260538 Acetyl-L-4-hydroxyproline Asreported 33996-33-7 250g $602 2026-06-03 Buy
Usbiological 260538 Acetyl-L-4-hydroxyproline Asreported 33996-33-7 500g $785 2026-06-03 Buy
Product number Packaging Price Buy
441562 10g $187 Buy
260538 50g $326 Buy
260538 100g $432 Buy
260538 250g $602 Buy
260538 500g $785 Buy

Oxaceprol Chemical Properties, Uses, Production

Chemical Properties

White powder

Originator

Jonctum,Merrell,France,1970

Uses

trans-1-Acetyl-4-hydroxy-L-proline can be used:

  • In the stereospecific synthesis of 4-fluoroglutamic acid.
  • To synthesize molecular targets for von Hippel-Lindau (VHL) E3 ubiquitin ligase.
  • As a precursor to synthesize pseudopoly(amino acids) such as poly(trans-4-hydroxy-4-acyl-L-proline ester) and a biodegradable polymer, poly(lactic acid-glycolic acid-4-hydroxyproline).

Manufacturing Process

16.7 g (0.127 mol) of L-hydroxyproline are dissolved in 400 ml of pure boiling acetic acid. With vigorous boiling and agitation, a mixture of 13.7 ml (0.154 mol) of rectified acetic anhydride and 250 ml of pure acetic acid is added during 25 minutes. Without discontinuing the stirring, contents of the flask are cooled by simply causing fresh air to circulate externally round the flask until the temperature of the mixture is reduced to about 35°C. The acetic acid is removed by using a rotary evaporator without exceeding 35°C under a vacuum of about 15 mm Hg. After one hour, 20 ml of anhydrous toluene are added, then 10 ml of anhydrous acetone; the mixture is homogenized and concentrated again as above during 30 minutes. Then 25 ml of acetone are added again, and subsequently 20 ml of toluene, the product being concentrated again; gradually the solution is converted into an amber-colored crystallized paste. Finally, 30 ml of acetone are added to the residue, and stirring is carried out until the oily fraction surrounding the crystals is dissolved. The product is then cooled in an ice chamber, centrifuged, washed with anhydrous acetone and eventually dried, After recrystallization from acetone, crystals are obtained, melting point 132°C.

Therapeutic Function

Antirheumatic

Flammability and Explosibility

Not classified

reaction suitability

reaction type: solution phase peptide synthesis

Oxaceprol synthesis

108-24-7
51-35-4
33996-33-7
Synthesis of Oxaceprol from Acetic anhydride and L-Hydroxyproline

Oxaceprol Preparation Products And Raw materials

Raw materials

L-Hydroxyproline Acetic anhydride

Preparation Products

2-Oxa-5-azabicyclo[2.2.1]heptan-3-one, 5-acetyl-, (1R,4R)- (9CI)

Oxaceprol Suppliers

Global Suppliers ( 296)
Supplier Tel Email Country ProdList Advantage
Taizhou Ruishinuo Pharmaceutical Technology Co., Ltd. 0523-86848872 19952992164;18652727964; 725236090@qq.com China 98 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai Chiral Chemicals Inc. 021-37285021 13472570865 tym7xi@aliyun.com China 299 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
Supplier Advantage
Taizhou Ruishinuo Pharmaceutical Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
INTATRADE GmbH 66
Alfa Aesar 84
Energy Chemical 61
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Pure Chemistry Scientific Inc. 62
Shanghai Chiral Chemicals Inc. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky (shanghai) International Co.,Ltd 60

Related articles

View Latest Price from Oxaceprol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Acetyl-L-hydroxyproline pictures 2026-09-11 N-Acetyl-L-hydroxyproline
33996-33-7
 1KG 98%min 500kgs WUHAN FORTUNA CHEMICAL CO., LTD
Oxaceprol pictures 2026-07-03 Oxaceprol
33996-33-7
 1kg 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
Oxaceprol pictures 2026-06-16 Oxaceprol
33996-33-7
 $29.00 99.32% 10g TargetMol Chemicals Inc.
  • Oxaceprol pictures
  • Oxaceprol
    33996-33-7
  • $0.00
  • 98%
  • Shaanxi Dideu New Materials Co. Ltd
  • Oxaceprol pictures
  • Oxaceprol
    33996-33-7
  • $29.00
  • 99.32%
  • TargetMol Chemicals Inc.

Oxaceprol Spectrum

Oxaceprol(33996-33-7)MSOxaceprol(33996-33-7)1HNMROxaceprol(33996-33-7)IR1Oxaceprol(33996-33-7)IR2

33996-33-7 (Oxaceprol) Related Search:

N-Tetradecanoyl-4-hydroxy-L-proline Oxaceprol Dipalmitoyl hydroxyproline L-Proline L-Hydroxyproline
N-Acetyl-L-Hydroxyproline trans-1-Benzoyl-4-hydroxy-L-proline methyl ester trans-1-Benzoyl-4-hydroxy-L-proline H-Gly-Hyp-OH H-Pro-Hyp-OH
H-Gly-Pro-Hyp-OH Methyl 1-(4-fluorobenzoyl)-4-hydroxy-2-pyrrolidinecarboxylate Z-Pro-Hyp-OH Poly-O-acetyl-L-hydroxyproline) 1-(4-Fluorobenzoyl)-4-hydroxy-2-pyrrolidinecarboxylic acid
Gly-Pro-hydroxy-Pro acetate salt 1-(2-Furylcarbonyl)-4-hydroxy-2-pyrrolidinecarboxylic acid H-Gly-Ala-Hyp-OH

1of4

N-ACETYLHYDROXY-L-PROLINE N-ALPHA-ACETYL-TRANS-4-HYROXY-L-PYROLLIDINE N-ALPHA-ACETYL-L-4-TRANS-HYDROXYPROLINE N-ALPHA-ACETYL-L-HYROXYPROLINE (-)-1-Acetyl-4β-hydroxy-L-proline (4R)-1-Acetyl-4-hydroxy-L-proline trans-1-Acetyl-4-hydroxy-L-proline 99% trans-1-Acetyl-4-hydroxy-L-proline, >=98% Ac-Hyp-OH≥ 95% (TLC) Nα-Acetyl-L-4-trans-hydroxyproline trans-1-Acetyl-4-hydroxy-L-proline Ac-L-Hyp (4R,2S)-1-ACETYL-4-HYDROXY-PYRROLIDINE-2-CARBOXYLIC ACID ACETYL-L-4-HYDROXYPROLINE ACETYL-4-HYDROXY-L-PROLINE AC-HYDROXYPROLINE OXACEPROL N-ACETYL-4-HYDROXY-L-PROLINE N-AC-L-HYP trans-l-prolin (R)-N-Acetyl-4-hydroxy-L-proline N-Acetyl-4-hydroxyproline N-Acetylhydroxyproline N-Acetyl-trans-4-hydroxy-L-proline AHP-200 CO-61 Jonctum N-Acetyl-L-hydroxyproline;trans-1-Acetyl-4-hydroxy-L-proline;1-Acetyl-4-hydroxy-2-pyrrolidinecarboxylic acid;AHP-200;CO-61;Jonctum;Oxaceprol 1-Acetyl-4-hydroxy-2-pyrrolidinecarboxylic acid Oxaceprol (trans-1-Acetyl-4-hydroxy-L-proline,monhydrate) Acetyl-trans-4-hydroxy-L-proline Hyp4001Ac-Hyp-Oh L-Proline, 1-acetyl-4-hydroxy-, (4R)- (9CI) (2S,4R)-N-ACETYL-4-HYDROXY-L-PROLINE N-Acetyl-L- 4-Hydroxyproline Ac-L-Hyp-OH N-alpha-Acetyl-L-4-hydroxyproline N-Acetyl-L-Hydroproline L-Proline, 1-acetyl-4-hydroxy-, (4R)- Oxaceprol USP/EP/BP OxaceprolQ: What is Oxaceprol Q: What is the CAS Number of Oxaceprol Q: What is the storage condition of Oxaceprol Q: What are the applications of Oxaceprol trans< Oxaceprol (N-acetyl-L-hydroxyproline) Oxaceprol, 10 mM in DMSO TRANS-1-ACETYL-4-HYDROXY-L-PROLINE (2S,4R)-1-Acetyl-4-hydroxypyrrolidine-2-carboxylic acid (2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID AC-HYP-OH NAHP N-ACETYL-L-HYDROXYPROLINE 33996-33-7 33966-33-7 33996-33-8 C7H11NO4 Peptide Synthesis Proline Derivatives Specialty Synthesis Unnatural Amino Acid Derivatives