3-TRIMETHYLSILYL-2-PROPYN-1-OL
- CAS No.
- 5272-36-6
- Chemical Name:
- 3-TRIMETHYLSILYL-2-PROPYN-1-OL
- Synonyms
- 3-(triMethylsilyl)prop-2-yn-1-ol;3-(TRIMETHYLSILYL)PROPARGYL ALCOHOL;3-TRIMETHYLSILANYL-PROP-2-YN-1-OL;3-Trimethylsilyl-2-propyn-1-ol,99%;2-Propyn-1-ol, 3-(trimethylsilyl)-;3-(Trimethylsilyl)propargyl alcohol 99%;DKSI027;TIMTEC-BB SBB009061;Trimethylsilylpropynol;3-Trimethylsilylpropargyl
- CBNumber:
- CB2482992
- Molecular Formula:
- C6H12OSi
- Molecular Weight:
- 128.24
- MDL Number:
- MFCD00002913
- MOL File:
- 5272-36-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-(Trimethylsilyl)propargyl alcohol 99% | 318558 | 5g | $71.2 |
| 3-Trimethylsilyl-2-propyn-1-ol >95.0%(GC) | T1500 | 5mL | $87 |
| TrimethylsilylpropargylAlcohol | T798175 | 5g | $180 |
| 3-TMSPROPARGYLALCOHOL | 83533 | 250g | $765.45 |
| 3-Trimethylsilyl-2-propyn-1-ol 95+% | AS26021 | 100g | $383 |
| More product size | |||
| Melting point | 63.5-65.0 °C |
|---|---|
| Boiling point | 76 °C11 mm Hg(lit.) |
| Density | 0.865 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 152 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Benzene (Sparingly) |
| pka | 13.71±0.10(Predicted) |
| form | Liquid |
| color | Clear yellow |
| Specific Gravity | 0.865 |
| Water Solubility | Not miscible with water. |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
| BRN | 1902505 |
| InChI | 1S/C6H12OSi/c1-8(2,3)6-4-5-7/h7H,5H2,1-3H3 |
| InChIKey | ZVGCJDPEKKEYES-UHFFFAOYSA-N |
| SMILES | C[Si](C)(C)C#CCO |
| CAS DataBase Reference | 5272-36-6(CAS DataBase Reference) |
| NIST Chemistry Reference | 3-Trimethylsilylpropargyl alcohol(5272-36-6) |
| EPA Substance Registry System | 2-Propyn-1-ol, 3-(trimethylsilyl)- (5272-36-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227-H301-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280h-P305+P351+P338-P309-P310 | |||||||||
| PPE | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 23-24/25-37/39-26 | |||||||||
| RIDADR | 2810 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8-10 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| NFPA 704 |
|
3-TRIMETHYLSILYL-2-PROPYN-1-OL price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 318558 | 3-(Trimethylsilyl)propargyl alcohol 99% | 5272-36-6 | 5g | $71.2 | 2026-03-19 | Buy |
| TCI Chemical | T1500 | 3-Trimethylsilyl-2-propyn-1-ol >95.0%(GC) | 5272-36-6 | 5mL | $87 | 2026-03-19 | Buy |
| TRC | T798175 | TrimethylsilylpropargylAlcohol | 5272-36-6 | 5g | $180 | 2021-12-16 | Buy |
| GFS CHEMICALS | 83533 | 3-TMSPROPARGYLALCOHOL | 5272-36-6 | 250g | $765.45 | 2021-12-16 | Buy |
| Activate Scientific | AS26021 | 3-Trimethylsilyl-2-propyn-1-ol 95+% | 5272-36-6 | 100g | $383 | 2021-12-16 | Buy |
3-TRIMETHYLSILYL-2-PROPYN-1-OL Chemical Properties,Uses,Production
Chemical Properties
clear yellow liquid
Uses
Trimethylsilylpropargyl alcohol is used as a reagent to synthesize Isbogrel, a Thromboxane A 2 (TXA 2) synthase inhibitor and also a TXA 2 receptor antagonist that has potential to treat asthma.
Application
3-Trimethylsilyl-2-propyn-1-ol is a colourless transparent liquid which is sensitive to light, air and moisture, and can be used as raw material for organic synthesis or reaction reagent. Alkyllithiums undergo trans addition to 3-(trimethylsilyl)-2-propyn-1-ols to yield (1-lithiovinyl)silanes. Due to unidentified side-reactions, yields do not exceed 20%.
Synthesis
![Tetrahydro-2-[[3-(trimethylsilyl)-2-propyn-1-yl]oxy]-2H-Pyran](/CAS/20180629/GIF/36551-06-1.gif)
36551-06-1
5272-36-6
Compound 5 (0.250 g, 1.17 mmol) was added dropwise to a flask containing methanol (4.0 mL) and Amberlyst-15 (0.025 g) under nitrogen protection at a reaction temperature of 0 °C. The reaction mixture was warmed to 40 °C and stirred for 8 hours. Upon completion of the reaction, the resin was removed by filtration and washed with ethyl acetate (10 mL). To the filtrate, 10% aqueous hydrochloric acid (10 mL) was added, followed by extraction of the organic layer with ethyl acetate (3 x 10 mL). The organic phases were combined and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the residue was purified by column chromatography (eluent: hexane/ethyl acetate = 9:1) to afford compound 6 in 96% yield (0.143 g, 1.12 mmol).
References
[1] Tetrahedron, 1996, vol. 52, # 21, p. 7487 - 7510
[2] Journal of the Brazilian Chemical Society, 2013, vol. 24, # 12, p. 1933 - 1941
[3] Chemistry - A European Journal, 2015, vol. 21, # 27, p. 9662 - 9665
[4] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1987, p. 1077 - 1082
[5] Journal of Organic Chemistry, 1995, vol. 60, # 14, p. 4650 - 4652
3-TRIMETHYLSILYL-2-PROPYN-1-OL Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13815 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29822 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
View Lastest Price from 3-TRIMETHYLSILYL-2-PROPYN-1-OL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 3-TRIMETHYLSILYL-2-PROPYN-1-OL
5272-36-6
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-11-18 | 3-TRIMETHYLSILYL-2-PROPYN-1-OL USP/EP/BP
5272-36-6
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2023-03-16 | 3-TRIMETHYLSILYL-2-PROPYN-1-OL
5272-36-6
|
US $0.00-0.00 / g | 10g | 98%Min | 1000kg | LY Global chemicals co.,ltd . |
-
- 3-TRIMETHYLSILYL-2-PROPYN-1-OL
5272-36-6
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-TRIMETHYLSILYL-2-PROPYN-1-OL USP/EP/BP
5272-36-6
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- 3-TRIMETHYLSILYL-2-PROPYN-1-OL
5272-36-6
- US $0.00-0.00 / g
- 98%Min
- LY Global chemicals co.,ltd .
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