3-Trimethylsilyl-2-propyn-1-ol
- CAS No.
- 5272-36-6
- Chemical Name:
- 3-Trimethylsilyl-2-propyn-1-ol
- Synonyms
- 3-(triMethylsilyl)prop-2-yn-1-ol;3-(TRIMETHYLSILYL)PROPARGYL ALCOHOL;3-TRIMETHYLSILANYL-PROP-2-YN-1-OL;2-Propyn-1-ol, 3-(trimethylsilyl)-;3-Trimethylsilyl-2-propyn-1-ol,99%;3-(Trimethylsilyl)propargyl alcohol 99%;DKSI027;TIMTEC-BB SBB009061;Trimethylsilylpropynol;3-Trimethylsilylpropargyl
- CBNumber:
- CB2482992
- Molecular Formula:
- C6H12OSi
- Molecular Weight:
- 128.24
- MDL Number:
- MFCD00002913
- MOL File:
- 5272-36-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 63.5-65.0 °C |
|---|---|
| Boiling point | 76 °C11 mm Hg(lit.) |
| Density | 0.865 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 152 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Benzene (Sparingly) |
| pka | 13.71±0.10(Predicted) |
| form | Liquid |
| color | Clear yellow |
| Specific Gravity | 0.865 |
| Water Solubility | Not miscible with water. |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
| BRN | 1902505 |
| InChI | 1S/C6H12OSi/c1-8(2,3)6-4-5-7/h7H,5H2,1-3H3 |
| InChIKey | ZVGCJDPEKKEYES-UHFFFAOYSA-N |
| SMILES | C[Si](C)(C)C#CCO |
| CAS DataBase Reference | 5272-36-6(CAS DataBase Reference) |
| NIST Chemistry Reference | 3-Trimethylsilylpropargyl alcohol(5272-36-6) |
| EPA Substance Registry System | 2-Propyn-1-ol, 3-(trimethylsilyl)- (5272-36-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227-H301-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280h-P305+P351+P338-P309-P310 | |||||||||
| PPE | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 23-24/25-37/39-26 | |||||||||
| RIDADR | 2810 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8-10 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| NFPA 704 |
|
3-Trimethylsilyl-2-propyn-1-ol price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 318558 | 3-(Trimethylsilyl)propargyl alcohol 99% | 5272-36-6 | 5g | $71.2 | 2026-04-30 | Buy |
| TCI Chemical | T1500 | 3-Trimethylsilyl-2-propyn-1-ol >95.0%(GC) | 5272-36-6 | 5mL | $87 | 2026-04-30 | Buy |
| Usbiological | 468235 | Trimethylsilylpropargyl Alcohol | 5272-36-6 | 2.5g | $418 | 2026-06-03 | Buy |
| Usbiological | 468235 | Trimethylsilylpropargyl Alcohol | 5272-36-6 | 5g | $566 | 2026-06-03 | Buy |
| TRC | TRC-T798175-5G | Trimethylsilylpropargyl Alcohol | 5272-36-6 | 5g | $249 | 2026-06-03 | Buy |
3-Trimethylsilyl-2-propyn-1-ol Chemical Properties, Uses, Production
Chemical Properties
clear yellow liquid
Uses
Trimethylsilylpropargyl alcohol is used as a reagent to synthesize Isbogrel, a Thromboxane A 2 (TXA 2) synthase inhibitor and also a TXA 2 receptor antagonist that has potential to treat asthma.
Application
3-Trimethylsilyl-2-propyn-1-ol is a colourless transparent liquid which is sensitive to light, air and moisture, and can be used as raw material for organic synthesis or reaction reagent. Alkyllithiums undergo trans addition to 3-(trimethylsilyl)-2-propyn-1-ols to yield (1-lithiovinyl)silanes. Due to unidentified side-reactions, yields do not exceed 20%.
Synthesis
![Tetrahydro-2-[[3-(trimethylsilyl)-2-propyn-1-yl]oxy]-2H-Pyran](/CAS/20180629/GIF/36551-06-1.gif)
36551-06-1
5272-36-6
Compound 5 (0.250 g, 1.17 mmol) was added dropwise to a flask containing methanol (4.0 mL) and Amberlyst-15 (0.025 g) under nitrogen protection at a reaction temperature of 0 °C. The reaction mixture was warmed to 40 °C and stirred for 8 hours. Upon completion of the reaction, the resin was removed by filtration and washed with ethyl acetate (10 mL). To the filtrate, 10% aqueous hydrochloric acid (10 mL) was added, followed by extraction of the organic layer with ethyl acetate (3 x 10 mL). The organic phases were combined and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the residue was purified by column chromatography (eluent: hexane/ethyl acetate = 9:1) to afford compound 6 in 96% yield (0.143 g, 1.12 mmol).
References
[1] Tetrahedron, 1996, vol. 52, # 21, p. 7487 - 7510
[2] Journal of the Brazilian Chemical Society, 2013, vol. 24, # 12, p. 1933 - 1941
[3] Chemistry - A European Journal, 2015, vol. 21, # 27, p. 9662 - 9665
[4] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1987, p. 1077 - 1082
[5] Journal of Organic Chemistry, 1995, vol. 60, # 14, p. 4650 - 4652
3-Trimethylsilyl-2-propyn-1-ol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| New Energy Chemicals | 0515-82159099 13770142076 | info@njuchem.com | China | 251 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
View Latest Price from 3-Trimethylsilyl-2-propyn-1-ol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 3-TRIMETHYLSILYL-2-PROPYN-1-OL USP/EP/BP
5272-36-6
|
$1.10 | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2026-03-20 | 3-TRIMETHYLSILYL-2-PROPYN-1-OL
5272-36-6
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2023-03-16 | 3-TRIMETHYLSILYL-2-PROPYN-1-OL
5272-36-6
|
10g | 98%Min | 1000kg | LY Global chemicals co.,ltd . |
-
- 3-TRIMETHYLSILYL-2-PROPYN-1-OL USP/EP/BP
5272-36-6
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- 3-TRIMETHYLSILYL-2-PROPYN-1-OL
5272-36-6
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-TRIMETHYLSILYL-2-PROPYN-1-OL
5272-36-6
- 98%Min
- LY Global chemicals co.,ltd .
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