4-Hydroxy-7-methoxyquinoline-3-carboxylic acid
- CAS No.
- 28027-17-0
- Chemical Name:
- 4-Hydroxy-7-methoxyquinoline-3-carboxylic acid
- Synonyms
- NSC 86135;AURORA 17949;ine-3-carboxyL;BUTTPARK 20\09-64;4-Hydroxy-7-methoxyquinoL;7-methoxy-4-oxo-1H-quinoline-3-carboxylicaci;7-Methoxy-4-hydroxyquinoline-3-carboxylic acid;4-Hydroxy-7-methoxy-3-quinolinecarboxylic acid;7-methoxy-4-oxo-1H-quinoline-3-carboxylic acid;4-Hydroxy-7-methoxyquinoline-3-carboxylic acid
- CBNumber:
- CB2672760
- Molecular Formula:
- C11H9NO4
- Molecular Weight:
- 219.19
- MDL Number:
- MFCD00024004
- MOL File:
- 28027-17-0.mol
- MSDS File:
- SDS
4-Hydroxy-7-methoxyquinoline-3-carboxylic acid price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR8293 | 4-Hydroxy-7-methoxyquinoline-3-carboxylic acid 97% | 28027-17-0 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR8293 | 4-Hydroxy-7-methoxyquinoline-3-carboxylic acid 97% | 28027-17-0 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR8293 | 4-Hydroxy-7-methoxyquinoline-3-carboxylic acid 97% | 28027-17-0 | 5g | $56 | 2026-06-04 | Buy |
| Apolloscientific | OR8293 | 4-Hydroxy-7-methoxyquinoline-3-carboxylic acid 97% | 28027-17-0 | 10g | $98 | 2026-06-04 | Buy |
| Apolloscientific | OR8293 | 4-Hydroxy-7-methoxyquinoline-3-carboxylic acid 97% | 28027-17-0 | 25g | $209 | 2026-06-04 | Buy |
4-Hydroxy-7-methoxyquinoline-3-carboxylic acid Chemical Properties, Uses, Production
Synthesis
63463-15-0
28027-17-0
General procedure for the synthesis of 4-hydroxy-7-methoxyquinoline-3-carboxylic acid from ethyl 4-hydroxy-7-methoxyquinoline-3-carboxylate: ethyl 4-hydroxy-7-methoxyquinoline-3-carboxylate (4.40 g, 17.80 mmol) was dissolved in 2 M NaOH solution and hydrolyzed by refluxing the reaction for 1 h at 110 °C. The mixture was cooled to room temperature and acidified with 2 M HCl solution. After completion of the reaction, the mixture was cooled to room temperature and acidified to pH 3-4 with 2 M HCl solution.After acidification, the precipitated white precipitate was collected by filtration, washed with water and dried to afford the target product 4-hydroxy-7-methoxyquinoline-3-carboxylic acid (2.50 g, 63% yield) with a melting point of 272 °C (literature value: Lauer et al., 1946, 257-260 °C). NMR hydrogen spectrum (400 MHz, DMSO-d6) δ: 3.90 (3H, s, OCH3), 7.17 (1H, dd, J = 2.4, 9.0 Hz, H-6), 7.29 (1H, d, J = 2.3 Hz, H-8), 8.16 (1H, d, J = 9.0 Hz, H-5), 8.72 (1H, s, H-2). 13.68 (1H, s, Ar-OH), 15.50 (1H, bs, -COOH). NMR carbon spectrum (100 MHz, DMSO-d6) δ: 56.3 (Ar-OCH3), 101.1 (C-3), 107.8 (C-8), 116.6 (C-4a), 118.9 (C-6), 127.3 (C-5), 142.0 (C-2), 145.0 (C-8a), 163.8 (C-4). 166.9 (C-7), 178.1 (COOH).
References
[1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 13, p. 3738 - 3748
[2] Journal of the American Chemical Society, 1946, vol. 68, p. 1268
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 25, p. 4918 - 4926
[4] Chemical and Pharmaceutical Bulletin, 2007, vol. 55, # 5, p. 821 - 824
[5] Patent: US6110929, 2000, A
4-Hydroxy-7-methoxyquinoline-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-Hydroxy-7-methoxyquinoline-3-carboxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| guoxinfu2006@163.com | 15822887609 | 15822887609@163.com | China | 58 | 58 |
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View Latest Price from 4-Hydroxy-7-methoxyquinoline-3-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID
28027-17-0
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2019-07-10 | 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID
28027-17-0
|
$1.00 | 1KG | 98% | 150KG | Career Henan Chemical Co |
-
- 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID
28027-17-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID
28027-17-0
- $1.00
- 98%
- Career Henan Chemical Co
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