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(S)-1-Boc-3-methylpiperazine

(S)-1-Boc-3-methylpiperazine structure

CAS No.: 147081-29-6

Chemical Name:: (S)-1-Boc-3-methylpiperazine

Synonyms: tert-butyl (S)-3-methylpiperazine-1-carboxylate;(S)-1-BOC-3-METHYLPIPERAZINE;(S)-TERT-BUTYL 3-METHYLPIPERAZINE-1-CARBOXYLATE;4-HYDROXY-7-METHOXYQUINOLINE-2-CARBOXYLIC ACID;(S)-3-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(3S)-3-MethyL;(S)-4-Boc-2-methylpiperazine;4-Hydroxy-7-methoxy-2-quinolinecarboxylic acid;CPD2809-SM;(S)-4-N-BOC-2-METHYL

CBNumber:: CB9458934

Molecular Formula:: C10H20N2O2

Molecular Weight:: 200.28

MDL Number:: MFCD02683204

MOL File:: 147081-29-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-08 07:26:47

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(S)-1-Boc-3-methylpiperazine Properties

Melting point	40-45 °C
Boiling point	268.7±15.0 °C(Predicted)
alpha	-16 º (c=1 in dioxane)
Density	0.997±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
pka	8.52±0.40(Predicted)
form	Crystalline Powder
color	White to yellow
optical activity	[α]/D -16±2°, c = 1 in dioxane
Sensitive	Air Sensitive
InChI	InChI=1S/C10H20N2O2/c1-8-7-12(6-5-11-8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3/t8-/m0/s1
InChIKey	FMLPQHJYUZTHQS-QMMMGPOBSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCN[C@@H](C)C1
CAS DataBase Reference	147081-29-6(CAS DataBase Reference)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H315-H318-H335

Precautionary statements

P280-P302+P352-P305+P351+P338+P310

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

37/38-41-34

Safety Statements

26-39-45-36/37/39

RIDADR

3259

WGK Germany

10-34

HS Code

29335990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Dam. 1
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
3		1

(S)-1-Boc-3-methylpiperazine price More Price(108)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	63207	(S)-1-Boc-3-methylpiperazine ≥98%	147081-29-6	5G	$120	2026-04-30	Buy
Sigma-Aldrich	63207	(S)-1-Boc-3-methylpiperazine ≥98%	147081-29-6	1g	$37.6	2025-07-31	Buy
TCI Chemical	D6010	(S)-1-Boc-3-methylpiperazine min. 98.0 %	147081-29-6	5G	$41	2026-04-30	Buy
TCI Chemical	D6010	(S)-1-Boc-3-methylpiperazine min. 98.0 %	147081-29-6	25G	$124	2026-04-30	Buy
Usbiological	263647	S-1-Boc-3-methylpiperazine Asreported	147081-29-6	2g	$305	2026-06-03	Buy

Product number	Packaging	Price	Buy
63207	5G	$120	Buy
63207	1g	$37.6	Buy
D6010	5G	$41	Buy
D6010	25G	$124	Buy
263647	2g	$305	Buy

(S)-1-Boc-3-methylpiperazine Chemical Properties, Uses, Production

Description

(S)-1-Boc-3-methylpiperazine is a hydrophobic compound that is structurally modified from the tetracyclic family of drugs. It has been shown to inhibit tumor cell growth by binding to the oncogene, KRASG12C, and downregulating its expression. This compound also inhibits cancer cell growth through the inhibition of the PI3K/AKT signaling pathway. The pharmacological effects of (S)-1-Boc-3-methylpiperazine are dependent on its ability to bind with high affinity to KRASG12C and inhibit its activity.

Chemical Properties

colorless to yellow liquid

Uses

Laboratory chemicals, Manufacture of substances.

Uses

(S)-4-Boc-2-methylpiperazine ((S)-1-Boc-3-methylpiperazine) is a reagent used in the synthesis of benzamide peptidomimetic as non-ATP competitive inihbitors.

Uses

Reactant involved in the synthesis of biologically activy molecules including:

CCR5 antagonists with anti-HIV-1 activity
Opioid receptor antagonists
Human growth hormone secretagogue receptor antagonists for treatment of obesity
Fatty acid oxidation inhibitors

Synthesis

24424-99-5

74879-18-8

147081-29-6

At 0 °C, (S)-2-methylpiperazine (400 mg) was dissolved in dichloromethane (20 mL) and di-tert-butyl dicarbonate (871 mg) was slowly added. The reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the reaction was quenched with deionized water (20 mL) followed by extraction with dichloromethane (2 x 40 mL). The organic phases were combined, washed with saturated sodium chloride solution (40 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford (S)-4-N-tert-butoxycarbonyl-2-methylpiperazine as a white solid (669 mg, 84% yield).

References

[1] Organic Process Research and Development, 2018, vol. 22, # 8, p. 978 - 990
[2] Patent: US2008/76758, 2008, A1. Location in patent: Page/Page column 88
[3] Patent: WO2008/70740, 2008, A1. Location in patent: Page/Page column 184
[4] Patent: US2005/261310, 2005, A1. Location in patent: Page/Page column 19
[5] Patent: WO2018/109050, 2018, A1. Location in patent: Paragraph 0226-0230; 0234-0236; 0240-0241

(S)-1-Boc-3-methylpiperazine synthesis

Synthesis of (S)-1-Boc-3-methylpiperazine from (S)-(+)-2-Methylpiperazine

(S)-1-Boc-3-methylpiperazine Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate (S)-(+)-2-Methylpiperazine

Preparation Products

UCB9608

(S)-1-Boc-3-methylpiperazine Suppliers

Global Suppliers ( 365)

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu Zhongde Jihua Pharmaceutical Technology Co., Ltd	15928014948; 15928014948	3438599507@qq.com	China	97	58
Chengdu Firster Pharmaceutical Co., Ltd.	028-87078428 028-87074958	chengzhenyong@cdfirster.com	China	2580	60
Shanghai Synteam Biochem CO.,ltd	+86-021-58380978 13482386415	info@systeambc.com	China	897	50
AstaTech(Chengdu) Biopharmaceutical Corp.	028-82666846 18080826311	sales@astatech.com.cn	China	499	58
SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD	0838-2809458 13350585791	pharm@biots.cn	China	774	58
Shanghai Fengluan Biotechnology Co., LTD	13357659136	jing.z@fengluanbiotech.com	China	497	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61

Supplier	Advantage
Chengdu Zhongde Jihua Pharmaceutical Technology Co., Ltd	58
Chengdu Firster Pharmaceutical Co., Ltd.	60
Shanghai Synteam Biochem CO.,ltd	50
AstaTech(Chengdu) Biopharmaceutical Corp.	58
SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD	58
Shanghai Fengluan Biotechnology Co., LTD	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chembest Research Laboratories Limited	61

View Latest Price from (S)-1-Boc-3-methylpiperazine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-15	(S)-4-N-Boc-2-methylpiperazine 147081-29-6	$37.00-788.00	10g	0.99	25kg	Shanghai UCHEM Inc.
2026-09-02	(S)-1-Boc-3-methylpiperazine 147081-29-6	$5.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-08-20	(S)-4-N-Boc-2-methylpiperazine 147081-29-6	$1.10	1g	99.00%	100 Tons	Dideu Industries Group Limited

(S)-4-N-Boc-2-methylpiperazine
147081-29-6
$37.00-788.00
0.99
Shanghai UCHEM Inc.

(S)-1-Boc-3-methylpiperazine
147081-29-6
$5.00
99%
Henan Fengda Chemical Co., Ltd

(S)-4-N-Boc-2-methylpiperazine
147081-29-6
$1.10
99.00%
Dideu Industries Group Limited

(S)-1-Boc-3-methylpiperazine Spectrum

(S)-4-N-Boc-2-methylpiperazine(147081-29-6)¹HNMR

147081-29-6 ((S)-1-Boc-3-methylpiperazine) Related Search:

(3S)-3-AMinoazepane-1-carboxylic Acid tert-Butyl Ester (S)-tert-butyl 3-formylpiperidine-1-carboxylate (S)-1-Boc-3-benzylpiperazine (S)-1-N-Boc-3-ethylpiperazine (S)-1-Boc-3-propylpiperazine

1-Boc-2-Methylpiperazine 4-N-Boc-2-Methyl-piperazine (S)-1-N-Boc-2-methylpiperazine (S)-2-tert-Butylcarboxamide-4-tert-butoxycarbonyl piperazine (R)-1-BOC-3-(Hydroxymethyl)piperazine

R-N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid (S)-1-Boc-3-methylpiperazine t-Butyl(2R,5S)-2,5-dimethylpiperazine-1-carboxylate (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester N-4-Boc-2-piperazinecarboxylic acid

(R)-1-N-Boc-2-methylpiperazine (R)-1-Boc-3-methylpiperazine (1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane

1of4

TERT-BUTYL (S)-3-METHYL-1-PIPERAZINECARBOXYLATE (S)-N4-BOC-2-METHYLPIPERAZINE (S)-1-TERT-BUTOXYCARBONYL-3-METHYLPIPERAZINE (S)-1-N-BOC-3-METHYLPIPERAZINE (S)-1-BOC-3-METHYLPIPERAZINE (S)-4-N-BOC-2-METHYL PIPERAZINE 1-PIPERAZINECARBOXYLIC ACID, 3-METHYL-, 1,1-DIMETHYLETHYL ESTER, (3S)- (S)-1-Boc-3-methylpiperazine≥ 99% (HPLC, Chiral purity) 4-BOC-2-(S)-METHYL-PIPERAZINE (3S)-1-BOC-3-METHYLPIPERAZINE (S)-3-Methyl-1-Boc-piperazine (S)-4-N-Boc-2-MethylPiperazinee (S)-4-N-Boc-2-methylpiperazine (S)-4-N-Boc-2-methyl piperazine (S)-2-METHYL-1-BOC-PIPERAZINE (S)-4-Boc-2-methylpiperazine (S)-2-Methylpiperazine, N4-BOC protected (S)-3-Methylpiperazine, N1-BOC protected 4-Hydroxy-7-methoxy-2-quinolinecarboxylic acid (S)-4-N-BOC-2-METHYL (s)-3-methyl-piperazine-1-carboxylic acid tert-butyl (S)-4-N-BOC-2-Methylpiperazine-HCl (3S)-3-Methylpiperazine-1-carboxylic acid tert-butyl ester tert-Butyl (3S)-3-methylpiperazine-1-carboxylate, (3S)-1-(tert-Butoxycarbonyl)-3-methylpiperazine (S)-1-Boc-3-Methylpiperazine (S)-1-Boc-3-Methylpiperazine, 98%+ (3S)-3-Methylpiperazine, N1-BOC protected Chemdraw8(S)-3-Methyl-piperazine-1-carboxylic acid tert-butyl ester CPD2809-SM (S)-4-N-Boc-2-methylpiperazine ISO 9001：2015 REACH 1-Piperazinecarboxylic acid, 3-methyl-, 1,1-dimethylethyl ester, (3S)- (9CI, ACI) Sotorasib Impurity 2 3-methyl-1-Piperazinecarboxylic acid 1,1-dimethylethyl ester (3S)- (9CI ACI) 3-Methyl-1-piperazinecarboxylic acid tert-butyl ester (3S)- (S)-1-Boc-3-methylpiperazine (S)-4-N-tert-Butyloxycarbonyl-2-methylpiperazine (3S)-3-MethyL (S)-3-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (S)-TERT-BUTYL 3-METHYLPIPERAZINE-1-CARBOXYLATE 4-HYDROXY-7-METHOXYQUINOLINE-2-CARBOXYLIC ACID tert-butyl (S)-3-methylpiperazine-1-carboxylate (S)-4-N-tert-Butoxycarbonyl-2-methylpiperazine 147081-29-6 Asymmetric Synthesis Chiral Building Blocks Heterocyclic Building Blocks Piperazines Piperazines pharmacetical Piperazine series Quinoline series Piperaizine 147081-29-6