ODQ
- CAS No.
- 41443-28-1
- Chemical Name:
- ODQ
- Synonyms
- ODQ;ODQ,98%;41443-28- 1;ODQ inhibitor;ODQ, 10 mM in DMSO;ODQ - CAS 41443-28-1 - Calbiochem;[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one;1H-[1,2,4]OXADIAZOLO[4,3-A]QUINOXALIN-1-ONE;1H-[1,2,4]OXADIAZOLE[4,3-A]QUINOXALIN-1-ONE;ODQ, NO-sensitive guanylyl cyclase inhibitor
- CBNumber:
- CB2730905
- Molecular Formula:
- C9H5N3O2
- Molecular Weight:
- 187.15
- MDL Number:
- MFCD00792620
- MOL File:
- 41443-28-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 160-170 °C |
|---|---|
| Boiling point | 321.89°C (rough estimate) |
| Density | 1.3753 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| RTECS | RO0913150 |
| storage temp. | 2-8°C |
| solubility | ethanol: 1.2 mg/mL |
| form | powder |
| pka | 0.94±0.20(Predicted) |
| color | pale yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| InChI | 1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H |
| InChIKey | LZMHWZHOZLVYDL-UHFFFAOYSA-N |
| SMILES | [n]21c(n[o][c]2=O)cnc3c1cccc3 |
| CAS DataBase Reference | 41443-28-1(CAS DataBase Reference) |
| FDA UNII | S57V2NMV38 |
| UNSPSC Code | 41106305 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
ODQ price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | O3636 | 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one powder | 41443-28-1 | 5mg | $129 | 2026-04-30 | Buy |
| Sigma-Aldrich | 495320 | ODQ | 41443-28-1 | 10mg | $253 | 2026-04-30 | Buy |
| TCI Chemical | O0400 | 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one >95.0%(GC) | 41443-28-1 | 25mg | $117 | 2026-04-30 | Buy |
| Cayman Chemical | 81410 | ODQ ≥98% | 41443-28-1 | 5mg | $40 | 2026-04-30 | Buy |
| Cayman Chemical | 81410 | ODQ ≥98% | 41443-28-1 | 10mg | $68 | 2026-04-30 | Buy |
ODQ Chemical Properties, Uses, Production
Description
ODQ (41443-28-1) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC),IC50= 20 nM).1 ODQ acts via competition with NO for the heme site of sGC where it binds irreversibly.2ODQ does not inhibit NO-mediated macrophage toxicity, an activity that is unrelated to cGMP nor does it inhibit particulate GC.1ODQ is an extremely useful tool to explore the involvement of the NO-cGMP pathway in cellular signaling and physiologic processes.3-5
Chemical Properties
ODQ is off-white to yellow powder
Uses
ODQ is a selective and potent sGC (soluble guanylyl cyclase) inhibitor.
Uses
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one inhibits neurite outgrowth and causes neurite retraction in PC12 cells independently of soluble guanylyl cyclase.
Definition
ChEBI: 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one is a member of the class of oxadiazoloquinoxalines that is 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline substituted at position 1 by an oxo group. It has a role as an EC 4.6.1.2 (guanylate cyclase) inhibitor.
Biological Activity
ODQ is a potent and selective inhibitor of NO-sensitive guanylyl cyclase.
Biochem/physiol Actions
H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) non competitively inhibits the action of nitric oxide-sensitive guanylyl cyclase and results in a supposedly irreversible oxidation of the prosthetic heme group. ODQ has been used to study the role of cyclic guanosine monophosphate (cGMP) pathway in nitric oxide (NO) signal transduction.
storage
+4°C
References
[1] J GARTHWAITE. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.[J]. Molecular Pharmacology, 1995, 48 2: 184-188.
[2] A SCHRAMMEL. Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase.[J]. Molecular Pharmacology, 1996, 50 1: 1-5.
[3] A G ESTÉVEZ. Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor.[J]. Journal of Neuroscience, 1998, 18 10: 3708-3714.
[4] G VANDECASTEELE R F T Eschenhagen. Role of the NO-cGMP pathway in the muscarinic regulation of the L-type Ca2+ current in human atrial myocytes.[J]. Journal of Physiology-London, 1998, 506 ( Pt 3): 653-663. DOI:10.1111/j.1469-7793.1998.653bv.x
[5] M C MARTINS-PINGE O U L G C Araújo. Nitric oxide-dependent guanylyl cyclase participates in the glutamatergic neurotransmission within the rostral ventrolateral medulla of awake rats.[J]. Hypertension, 1999, 34 4 Pt 2: 748-751. DOI:10.1161/01.hyp.34.4.748
ODQ Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
