Brompheniramine hydrogen maleate
- CAS No.
- 980-71-2
- Chemical Name:
- Brompheniramine hydrogen maleate
- Synonyms
- BROMPHENIRAMINE MALEATE;dimegan;dimetane;dimotane;ilvinmaleate;Rolabromophen;dimetanemaleate;Brompheniramine MaL;BroMpheniraMine hydr;parabromdylaminemaleate
- CBNumber:
- CB2736194
- Molecular Formula:
- C20H23BrN2O4
- Molecular Weight:
- 435.31
- MDL Number:
- MFCD00057367
- MOL File:
- 980-71-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 134-135°C |
|---|---|
| Flash point | 9℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride. |
| form | Solid |
| color | White to Off-White |
| λmax | 261nm(lit.) |
| Merck | 14,1443 |
| Stability | Hygroscopic |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1S/C16H19BrN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChIKey | SRGKFVAASLQVBO-BTJKTKAUSA-N |
| SMILES | C(C1=CC=C(Br)C=C1)(C1=NC=CC=C1)CCN(C)C.C(O)(=O)/C=C\C(O)=O |
| LogP | 3.565 (est) |
| CAS DataBase Reference | 980-71-2(CAS DataBase Reference) |
| FDA 21 CFR | 341.12 |
| EWG's Food Scores | 1 |
| FDA UNII | IXA7C9ZN03 |
| EPA Substance Registry System | 2-Pyridinepropanamine, .gamma.-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) (980-71-2) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn,Xi,T,F | |||||||||
| Risk Statements | 22-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 36-45-36/37-16-7 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | US4025000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 38220090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
Brompheniramine hydrogen maleate price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B1153000 | (±)-Brompheniramine maleate salt European Pharmacopoeia (EP) Reference Standard | 980-71-2 | 50 mg | $170 | 2026-04-30 | Buy |
| Sigma-Aldrich | B-043 | Brompheniramine maleate solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 980-71-2 | 1mL | $53.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1078008 | (±)-Brompheniramine maleate salt | 980-71-2 | 125mg | $360 | 2026-04-30 | Buy |
| TCI Chemical | B5167 | Brompheniramine Maleate >98.0%(HPLC)(T) | 980-71-2 | 25g | $91 | 2026-04-30 | Buy |
| Cayman Chemical | 20996 | Brompheniramine (maleate) ≥95% | 980-71-2 | 10mg | $36 | 2026-04-30 | Buy |
Brompheniramine hydrogen maleate Chemical Properties, Uses, Production
Description
Brompheniramine is a first generation antihistamine of the propylamine class. It antagonizes histamine H1 receptors (Ki = 6.06 nM) and also inhibits the reuptake of serotonin and norepinephrine.
Chemical Properties
White Solid
Originator
Dimetane,Robins,US,1957
Uses
This drug is only available in combination with other medications: Bromfed, Dimetane, Dimetapp, Drixomed, Histatab, Nasahist. The only difference between this agent and chlorpheniramine is the substitution of a bromine for a chlorine atom in brompheniramine.
Uses
Antihistaminic;H1 Antagonist
Uses
An antihistamine and also an inhibitor of serotonin reuptake
Definition
ChEBI: The maleic acid salt of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.
Manufacturing Process
Initially, 4-bromobenzyl-cyanide is reacted with sodium amide and 2- chloropyridine to give bromophenyl-pyridyl acetonitrile. This is then reacted with sodium amide then dimethyl amino ethyl chloride to give 4-bromophenyldimethylaminoethyl- pyridyl acetonitrile. This intermediate is then hydrolyzed and decarboxylated to bromphenirame using 80% H2SO4 at 140°-150°C for 24 hours. The brompheniramine maleate may be made by reaction with maleic acid in ethanol followed by recrystallization from pentanol.
brand name
Dimetane (Wyeth).
Therapeutic Function
Antihistaminic
General Description
Brompheniraminemaleate, (+)2-[p-bromo-α-[2-(dimethylamino)ethyl]benzyl]pyridine bimaleate (Dimetane), differs fromchlorpheniramine by the substitution of a bromine atom forthe chlorine atom. Its actions and uses are like those of chlorpheniramine.It has a half-life of 25 hours, which is almosttwice that of chlorpheniramine.
Side effects
The side effects of this medication are similar to other classes of sedative antihistamines. Some medications include parabens. Patients sensitive to parabens may develop a sensitivity reaction.
References
[1] THOMAS HOEGBERG. Synthesis of pyridylallylamines related to zimelidine and their inhibition of neuronal monoamine uptake[J]. Journal of Medicinal Chemistry, 1981, 24 12: 1499-1507. DOI: 10.1021/jm00144a025
Brompheniramine hydrogen maleate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenyang Syndy Chemistry Institute | -- | China | 16 | 42 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 | China | 4484 | 50 |
View Latest Price from Brompheniramine hydrogen maleate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Brompheniramine maleate
980-71-2
|
$29.00-48.00 | 99.80% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-15 | Brompheniramine maleate
980-71-2
|
$29.00-48.00 | 99.80% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-15 | Brompheniramine maleate
980-71-2
|
$29.00-48.00 | 99.80% | 10g | TargetMol Chemicals Inc. |
-
- Brompheniramine maleate
980-71-2
- $29.00-48.00
- 99.80%
- TargetMol Chemicals Inc.
-
- Brompheniramine maleate
980-71-2
- $29.00-48.00
- 99.80%
- TargetMol Chemicals Inc.
-
- Brompheniramine maleate
980-71-2
- $29.00-48.00
- 99.80%
- TargetMol Chemicals Inc.
