N-Boc-3-pyrrolidinone
- CAS No.
- 101385-93-7
- Chemical Name:
- N-Boc-3-pyrrolidinone
- Synonyms
- TERT-BUTYL 3-OXOPYRROLIDINE-1-CARBOXYLATE;tert-butyl 2-oxopyrrolidine-1-carboxylate;1-tert-Butoxycarbonyl-3-pyrrolidone;3-OXO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;N-Boc-3-pyrroL;BOC-3-PYRROLIDINONE;1-BOC-3-PYRROLIDONE;N-Boc-3-pyrolidinone;N-BOC-3-Pyrrolodinone;1-BOC-3-PYRROLIDINONE
- CBNumber:
- CB2740029
- Molecular Formula:
- C9H15NO3
- Molecular Weight:
- 185.22
- MDL Number:
- MFCD01631194
- MOL File:
- 101385-93-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 34-38 °C (lit.) |
|---|---|
| Boiling point | 270.9±33.0 °C(Predicted) |
| Density | 1.133±0.06 g/cm3(Predicted) |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | Dichloromethane, Ethyl Acetate, Methanol |
| pka | -1.79±0.20(Predicted) |
| form | Low Melting Solid |
| color | White to yellow to orange |
| Water Solubility | Insoluble in water. |
| InChI | InChI=1S/C9H15NO3/c1-9(2,3)13-8(12)10-5-4-7(11)6-10/h4-6H2,1-3H3 |
| InChIKey | JSOMVCDXPUXKIC-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC(=O)C1 |
| CAS DataBase Reference | 101385-93-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-37/38-41-36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36/37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
N-Boc-3-pyrrolidinone price More Price(96)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 637564 | N-Boc-3-pyrrolidinone 97% | 101385-93-7 | 1g | $41.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | 637564 | N-Boc-3-pyrrolidinone 97% | 101385-93-7 | 10g | $371 | 2026-04-30 | Buy |
| TCI Chemical | B3589 | 1-tert-Butoxycarbonyl-3-pyrrolidone >95.0%(GC) | 101385-93-7 | 1g | $19 | 2026-04-30 | Buy |
| TCI Chemical | B3589 | 1-tert-Butoxycarbonyl-3-pyrrolidone >95.0%(GC) | 101385-93-7 | 5g | $34 | 2026-04-30 | Buy |
| Usbiological | 261771 | N-Boc-3-pyrrolidinone ≥97%(GC) | 101385-93-7 | 10g | $319 | 2026-06-03 | Buy |
N-Boc-3-pyrrolidinone Chemical Properties, Uses, Production
Description
N-Boc-3-pyrrolidinone is an organic compound insoluble in water. It is a starting material for the synthesis of spirocyclic tetrahydrofuran and is also used in studies related to the preparation of 5-membered heterocyclic secondary alcohols with carrot as a biocatalyst[1].
Chemical Properties
Brown Oil
Uses
In the Synthesis and antibacterial evaluation of a novel series of rifabutin-like spirorifamycins 1-Boc-3-pyrrolidinone is used.
Uses
Used in a study of asymmetric hydrogen-transfer bioreduction of ketones with Leifsonia alcohol dehydrogenase.
Synthesis
83220-73-9
101385-93-7
General procedure for the synthesis of 1-tert-butoxycarbonyl-3-hydroxy-pyrrolidine from 1-tert-butoxycarbonyl-3-pyrrolidinone: To a dichloromethane (20 mL) solution of oxalyl chloride (2.8 mL, 32.4 mmol) a dichloromethane (40 mL) solution of dimethylsulfoxide (DMSO, 4.6 mL, 64.8 mmol) was slowly added at -78 °C, and subsequently the reaction mixture was stirred at -15 °C for 5 min. Next, a dichloromethane (60 mL) solution of N-Boc-3-pyrrolidinol (4.04 g, 21.6 mmol) was added at -78°C and stirring was continued for 2 hours at this temperature. Subsequently, triethylamine (15 mL, 108 mmol) was added to the reaction mixture and stirred at -78 °C for 1 hour. After that, the reaction mixture was slowly warmed to room temperature and stirring was continued for 2 hours at room temperature. After completion of the reaction, the mixture was cooled to 0 °C and the reaction was quenched with saturated sodium bicarbonate (NaHCO3) solution and diluted with ethyl acetate. The organic layer was washed sequentially with saturated sodium bicarbonate solution and saturated saline. The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the crude product 1-tert-butoxycarbonyl-3-pyrrolidinone (4 g, 100% yield), which could be used for subsequent reactions without further purification. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 3.79-3.75 (m, 4H), 2.58 (t, J = 8.0 Hz, 2H), 1.47 (s, 9H).
References
[1] NAIRA VIEIRA MACHADO á. O. Enantioselective reduction of heterocyclic ketones with low level of asymmetry using carrots[J]. Biocatalysis and Biotransformation, 2021. DOI:10.1080/10242422.2021.1879795.
N-Boc-3-pyrrolidinone Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ITIC MEDCHEM(SUZHOU) CO.,LTD. | 0512-68323967 18015559028 | sales@iticmedchem.com | China | 528 | 61 |
| Suzhou Highfine Biotech Co., Ltd | 0512-69209928 18796809688 | zhouyingxiang@highfine.com | China | 472 | 75 |
| Mashilabs (Shanghai) Co.,Ltd. | 19916721580 | mafarm@126.com | China | 4534 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Suzhou Uugene Biopharma Co., Ltd. | 0512-69561956 18015581618 | sales@uugene.com | China | 111 | 55 |
| BTC Pharmaceutical CO. Ltd | +86-15716293042 15716293042 | info@btcpharm.com | China | 822 | 55 |
| Jinan Dexinjia Bio&Tech Co., Ltd | 0531-82375880 15098789112 | 3845379039@qq.com | China | 1457 | 58 |
| Shanghai Hobor Chemical Co., Ltd | 13918007836 | sales@hoborchem.com | China | 423 | 60 |
| Shanghai Baoda Biotechnology Co., Ltd. | 15900974796 | gjzhu@blpharm.net | China | 197 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
View Latest Price from N-Boc-3-pyrrolidinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | N-Boc-3-pyrrolidinone
101385-93-7
|
$12.00 | 1KG | 99% | 200mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-09-17 | N-Boc-3-pyrrolidinone
101385-93-7
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-20 | N-Boc-3-pyrrolidinone
101385-93-7
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- N-Boc-3-pyrrolidinone
101385-93-7
- $12.00
- 99%
- Jinan Finer Chemical Co., Ltd
-
- N-Boc-3-pyrrolidinone
101385-93-7
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- N-Boc-3-pyrrolidinone
101385-93-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
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