ChemicalBook >> CAS DataBase List >>Ac-IEPD-PNA
Ac-IEPD-PNA
- CAS No.
- 216757-29-8
- Chemical Name:
- Ac-IEPD-PNA
- Synonyms
- Ac-IEPD-PNA;AC-ILE-GLU-PRO-ASP-PNA;AC-ILE-GLU-PRO-ASP-PARANITROANILIDE;N-ACETYL-ILE-GLU-PRO-ASP-P-NITROANILINE;N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide;GRANZYME B SUBSTRATE VIII, COLORIMETRIC;N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide;N-ACETYL-ILE-GLU-PRO-ASP-P-NITROANILIDE;AC-IETD-PNA;L-α-Asparagine, N-acetyl-L-isoleucyl-L-α-glutamyl-L-prolyl-N-(4-nitrophenyl)- (9CI)
- CBNumber:
- CB2762317
- Molecular Formula:
- C28H38N6O11
- Molecular Weight:
- 634.64
- MDL Number:
- MFCD02259221
- MOL File:
- 216757-29-8.mol
- MSDS File:
- SDS
Last updated:2026-09-12 18:51:26
| Boiling point | 1096.9±65.0 °C(Predicted) |
|---|---|
| Density | 1.386±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMSO: soluble |
| form | powder |
| pka | 4.06±0.10(Predicted) |
| color | White to off-white |
| Sequence | Ac-Ile-Glu-Pro-Asp-{pNA} |
| InChIKey | YXEIIOVAGGAMCZ-NYMCBPKFSA-N |
| SMILES | CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)Nc2ccc(cc2)[N+]([O-])=O |
| UNSPSC Code | 12352209 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
Ac-IEPD-PNA price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A6470 | N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide ≥97% (HPLC), powder | 216757-29-8 | 5MG | $488 | 2026-04-30 | Buy |
| Sigma-Aldrich | 368067-M | Granzyme B Substrate VIII, Colorimetric A colorimetric substrate for granzyme B (kcat/Km = 6.6 x 10⁴ M⁻¹s⁻¹). | 5 mg | $151 | 2026-04-30 | Buy | |
| Sigma-Aldrich | 368067-M | Granzyme B Substrate VIII, Colorimetric A colorimetric substrate for granzyme B (kcat/Km = 6.6 x 10⁴ M⁻¹s⁻¹). | 1 unit | $141 | 2025-07-31 | Buy | |
| Biosynth | FA110813 | Ac-Ile-Glu-Pro-Asp-pNA | 216757-29-8 | 5mg | $900 | 2026-06-04 | Buy |
| Biosynth | FA110813 | Ac-Ile-Glu-Pro-Asp-pNA | 216757-29-8 | 10mg | $900 | 2026-06-04 | Buy |
Ac-IEPD-PNA Chemical Properties, Uses, Production
Uses
N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide (Ac-IEPD-pNA) is a granzyme B substrate that allows accurate measurement of granzyme B activity[1].
Biological Activity
Primary Target
Colorimetric substrate for granzyme B', 'kcat/Km = 6.6 x 104 M-¹ sec-¹ as substrate for granzyme B
References
[1] Kristina Fritsch, et al. Suppression of granzyme B activity and caspase-3 activation in leukaemia cells constitutively expressing the protease inhibitor 9. Ann Hematol. 2013 Dec;92(12):1603-9. DOI:10.1007/s00277-013-1846-6
Ac-IEPD-PNA Preparation Products And Raw materials
Raw materials
Preparation Products
Ac-IEPD-PNA Suppliers
Global Suppliers ( 94)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 1010 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Shanghai Xilong Biochemical Technology Co., Ltd. | 021-52907766-8042 | China | 9928 | 58 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-20242659 18930833303 | sales@changyanchem.cn | China | 4998 | 55 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
216757-29-8 (Ac-IEPD-PNA) Related Search:
N-ACETYL-ILE-GLU-PRO-ASP-P-NITROANILINE
AC-ILE-GLU-PRO-ASP-PARANITROANILIDE
AC-ILE-GLU-PRO-ASP-PNA
N-ACETYL-ILE-GLU-PRO-ASP-P-NITROANILIDE;AC-IETD-PNA
GRANZYME B SUBSTRATE VIII, COLORIMETRIC
N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide
L-α-Asparagine, N-acetyl-L-isoleucyl-L-α-glutamyl-L-prolyl-N-(4-nitrophenyl)- (9CI)
N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide
Ac-IEPD-PNA
216757-29-8
C28H38N6O11
Pepetides
