2-Fluoro-5-bromoanisole
- CAS No.
- 103291-07-2
- Chemical Name:
- 2-Fluoro-5-bromoanisole
- Synonyms
- 4-Bromo-1-fluoro-2-methoxybenzene;2-fluoro-bromoanisole;2-fluoro-5-bromoanisole;2-FLUORO-5-BROMO ANISOLE,=98%;Benzene,4-broMo-1-fluoro-2-Methoxy;4-Bromo-1-fluoro-2-methoxybenzene, 5-Bromo-2-fluorophenyl methyl ether
- CBNumber:
- CB2854827
- Molecular Formula:
- C7H6BrFO
- Molecular Weight:
- 205.02
- MDL Number:
- MFCD01861130
- MOL File:
- 103291-07-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335-H412 |
| Precautionary statements | P273-P301+P312+P330-P302+P352-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36-52 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 2909309090 |
2-Fluoro-5-bromoanisole price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC2913 | 5-Bromo-2-fluoroanisole 97% | 103291-07-2 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC2913 | 5-Bromo-2-fluoroanisole 97% | 103291-07-2 | 25g | $32 | 2026-06-04 | Buy |
| Activate Scientific | AS32773 | 2-Fluoro-5-bromoanisole 97% | 103291-07-2 | 5g | $20 | 2026-06-04 | Buy |
| Activate Scientific | AS32773 | 2-Fluoro-5-bromoanisole 97% | 103291-07-2 | 25g | $61 | 2026-06-04 | Buy |
| Activate Scientific | AS32773 | 2-Fluoro-5-bromoanisole 97% | 103291-07-2 | 100g | $129 | 2026-06-04 | Buy |
2-Fluoro-5-bromoanisole Chemical Properties, Uses, Production
Chemical Properties
Pale yellow liquid
Uses
5-Bromo-2-fluoroanisole is a reactant used in the preparation of bicyclic substituted hydroxyphenylmethanone derivatives as 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors for the treatment of osteoporosis.
Synthesis
112204-58-7
74-88-4
103291-07-2
5-Bromo-2-fluorophenol (13.0 g, 68.1 mmol) and iodomethane (19.3 g, 136 mmol) were dissolved in DMF (120 mL) and potassium carbonate (18.8 g, 136 mmol) was added. The reaction mixture was stirred at room temperature for 65 hours. After completion of the reaction, water (150 mL) was added to the reaction solution and extracted with ethyl acetate (100 mL x 1,50 mL x 2). The organic layers were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give a light yellow oily crude product (29.0 g). The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=10:1) to afford 5-bromo-2-fluoroanisole (14.2 g, yield: quantitative) in colorless oily form. The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3) and 19F-NMR (376 MHz, CDCl3): 1H-NMR δ 3.88 (s, 3H), 6.95 (dd, J = 8.6 and 10.8 Hz, 1H), 7.02 (ddd, J = 2.2,4.2 and 8.6 Hz, 1H), 7.08 (dd. J = 2.2 and 7.6 Hz, 1H); 19F-NMR δ -137 (s, 1F).
References
[1] Patent: US2016/24110, 2016, A1. Location in patent: Paragraph 0452; 0453
[2] Patent: WO2006/76246, 2006, A2. Location in patent: Page/Page column 87
[3] Patent: US2010/227894, 2010, A1. Location in patent: Page/Page column 28
[4] Patent: US2007/3539, 2007, A1. Location in patent: Page/Page column 71
2-Fluoro-5-bromoanisole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
View Latest Price from 2-Fluoro-5-bromoanisole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 2-Fluoro-5-bromoanisole
103291-07-2
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2019-12-26 | 2-Fluoro-5-bromoanisole
103291-07-2
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 2-Fluoro-5-bromoanisole
103291-07-2
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2-Fluoro-5-bromoanisole
103291-07-2
- $1.00
- 99%
- Career Henan Chemical Co
