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1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate

1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate structure

CAS No.: 138647-49-1

Chemical Name:: 1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate

Synonyms: 1(2H)-Pyridinecarboxylic ...;1-Boc-1,2,3,6-tetrahydropyridin-4-;N-Boc-4-trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine;Tert-butyl 4-(trifluoromethylsulfonyloxy)-3,6-dihydro-2h-pyr;1-Boc-4-(trifluoromethylsulfonyloxy)-5,6-dihydro-2H-pyridine;1-Boc-4-(trifluoromethanesulfonyloxy)-3,6-dihydro-2H-pyridine;1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluo...;4-[(trifluoromethyl)sulfonyloxy]-5,6-dihydropyridine-1(2H)-carboxylate;1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate;TERT-BUTYL 4-(TRIFLUOROMETHYLSULFONYLOXY)-5,6-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE

CBNumber:: CB2970879

Molecular Formula:: C11H16F3NO5S

Molecular Weight:: 331.31

MDL Number:: MFCD09997858

MOL File:: 138647-49-1.mol

MSDS File:: SDS

Last updated:2026-05-28 00:52:42

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1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate Properties

Boiling point	361.2±42.0 °C(Predicted)
Density	1.40±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
pka	-3.55±0.40(Predicted)
form	solid
color	Beige
InChI	InChI=1S/C11H16F3NO5S/c1-10(2,3)19-9(16)15-6-4-8(5-7-15)20-21(17,18)11(12,13)14/h4H,5-7H2,1-3H3
InChIKey	WUBVEMGCQRSBBT-UHFFFAOYSA-N
SMILES	C1N(C(OC(C)(C)C)=O)CC=C(OS(C(F)(F)F)(=O)=O)C1
CAS DataBase Reference	138647-49-1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332-H315-H319-H335
Precautionary statements	P260-P271-P280
HS Code	2933399990

1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	21066	N-BOC-4-TRIFLUOROMETHANESULFONYLOXY-3,6-DIHYDRO-2H-PYRIDINE 97%	138647-49-1	1G	$25	2026-04-30	Buy
AstaTech	21066	N-BOC-4-TRIFLUOROMETHANESULFONYLOXY-3,6-DIHYDRO-2H-PYRIDINE 97%	138647-49-1	5G	$85	2026-04-30	Buy
AstaTech	21066	N-BOC-4-TRIFLUOROMETHANESULFONYLOXY-3,6-DIHYDRO-2H-PYRIDINE 97%	138647-49-1	25G	$299	2026-04-30	Buy
Apolloscientific	PC200076	1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulphonate 97%	138647-49-1	1g	$21	2026-06-04	Buy
Apolloscientific	PC200076	1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulphonate 97%	138647-49-1	5g	$41	2026-06-04	Buy

Product number	Packaging	Price	Buy
21066	1G	$25	Buy
21066	5G	$85	Buy
21066	25G	$299	Buy
PC200076	1g	$21	Buy
PC200076	5g	$41	Buy

1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate Chemical Properties, Uses, Production

Synthesis

N-Phenyl-bis(trifluoromethanesulfonimide)

37595-74-7

1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate

138647-49-1

The general procedure for the synthesis of tert-butyl 4-(((trifluoromethyl)sulfonyl)oxy)-5,6-dihydropyridine-1(2H)-carboxylate from N-phenylbis(trifluoromethylsulfonyl)imide was as follows: diisopropylamine (22 ml) was dissolved in anhydrous THF (125 ml) and the solution was cooled down to -78 °C. Slowly add n-butyllithium (62.5 ml, 2.5 M hexane solution). After stirring for 15 min, a solution of tert-butyl 4-oxopiperidine-1-carboxylate (28.32 g) in THF (100 ml) was added dropwise. The reaction mixture was continued to be stirred at -78 °C for 1 h followed by dropwise addition of THF (150 ml) solution of N-phenyl trifluoromethanesulfonimide (53.8 g). The reaction mixture was stirred at -78 °C for 2 h. The mixture was slowly warmed to room temperature and stirred overnight. After completion of the reaction, the mixture was concentrated in vacuum and the residue was dissolved in ether (1000 ml). The organic layer was washed sequentially with water (500 ml), 2M sodium hydroxide solution (3 x 500 ml), water (500 ml) and brine (500 ml), then dried with magnesium sulfate, and concentrated to give tert-butyl 4-(((trifluoromethyl)sulfonyl)oxy)-5,6-dihydropyridine-1(2H)-carboxylate as a light brown oil (45.38 g, 96% yield). It could be used in the subsequent reaction without further purification. The product was confirmed by 1H NMR (CDCl3): δ1.48 (9H, s), 2.44 (2H, m), 3.63 (2H, t), 4.00 (2H, q), 5.70 (1H, br).

References

[1] Patent: WO2007/60409, 2007, A1. Location in patent: Page/Page column 87-88
[2] Patent: WO2003/87057, 2003, A1. Location in patent: Page/Page column 77-78
[3] Patent: WO2006/4532, 2006, A1. Location in patent: Page/Page column 25
[4] Patent: WO2007/92435, 2007, A2. Location in patent: Page/Page column 143-143
[5] Patent: WO2004/35549, 2004, A1. Location in patent: Page 127

1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate Preparation Products And Raw materials

Raw materials

[bis[(trifluoromethyl)sulphonyl]methyl]benzene trifluoromethanesulfonanilide N-Phenyl-bis(trifluoromethanesulfonimide) N-(tert-Butoxycarbonyl)-4-piperidone 2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine

Diisopropylamine Tetrahydrofuran n-Butyllithium

1of2

Preparation Products

2-(1 Lamda{2}-piperidin-4-yl)pyridin-4-yl dihydrochloride 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-4-[2-methyl-5-(1-methylethoxy)-4-nitrophenyl]-, 1,1-dimethylethyl ester tert-butyl 5,6-dihydro-4-(4-nitrophenyl)pyridine-1(2H)-carboxylate tert-butyl 4-(4-fluorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate tert-butyl 4-(2-cyanophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate Suppliers

Global Suppliers ( 137)

Supplier	Tel	Email	Country	ProdList	Advantage
Tetranov Biopharm	13526569071	sales@leadmedpharm.com	China	7881	64
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Shanghai Sunway Pharmaceutical Technology Co., Ltd	13761987713	hxzheng@sunwaypharm.cn	China	8663	57
QINGDAO CARELONGPHARMATECH CO.,LTD	053288191853 13061484198	sales@carelongchem.com	China	455	57
Shanghai Holy Biohemdeviser Co., Ltd	021-61551100		China	443	57
Thermo Fisher Scientific	800-810-5118	cnchemical@thermofisher.com	China	17752	75
Shanghai Topbiochem Technology Co., Ltd	021-58170097	info@topbiochem.com	China	9513	58
Shanghai potentpharm CO.,Ltd	13524892556	sales-cn@potentpharm.com	China	1011	55
Shanghai potentpharm CO.,Ltd	(86) 21 51969655		China	486	22

Supplier	Advantage
Tetranov Biopharm	64
J & K SCIENTIFIC LTD.	76
Shanghai Hanhong Scientific Co.,Ltd.	64
Shanghai Sunway Pharmaceutical Technology Co., Ltd	57
QINGDAO CARELONGPHARMATECH CO.,LTD	57
Shanghai Holy Biohemdeviser Co., Ltd	57
Thermo Fisher Scientific	75
Shanghai Topbiochem Technology Co., Ltd	58
Shanghai potentpharm CO.,Ltd	55
Shanghai potentpharm CO.,Ltd	22

View Latest Price from 1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate 138647-49-1		1KG	98%	150KG	Career Henan Chemical Co

1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate
138647-49-1
$0.00
98%
Career Henan Chemical Co

1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate Spectrum

1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate(138647-49-1)¹HNMR

138647-49-1 (1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate) Related Search:

N-Boc-1,2,3,6-tetrahydropyridine Ethyl trifluoromethanesulfonate 1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate

1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate TERT-BUTYL 4-(TRIFLUOROMETHYLSULFONYLOXY)-5,6-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE 3,6-Dihydro-4-[[(trifluoromethyl)sulfonyl]oxy]-1(2H)-pyridinecarboxylic acid tert-butyl ester 1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydro-4-[[(trifluoromethyl)sulfonyl]oxy]pyridine tert-Butyl 4-(trifluoromethanesulfonyloxy)-1,2,3,6-tetrahydropyridine-1-carboxylate Tert-butyl 4-(trifluoromethylsulfonyloxy)-3,6-dihydro-2h-pyr 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-4-[[(trifluoromethyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester N-Boc-4-trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine 4-[(trifluoromethyl)sulfonyloxy]-5,6-dihydropyridine-1(2H)-carboxylate tert-Butyl-4{[(trifluoroMethyl)sulfonyl]oxy}-1,2,3,6-tetrahydro-1-pyridinecarboxylate 1(2H)-Pyridinecarboxylic ... tert-Butyl 4-[(trifluoromethane)sulphonyloxy]-1,2,3,6-tetrahydropyridine-1-carboxylate 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 1-Boc-4-(trifluoromethanesulfonyloxy)-3,6-dihydro-2H-pyridine 1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulphonate tert-butyl4-(((trifluoromethyl)sulfonyl)oxy)-3,6-dihydropyridine-1(2H)-carboxylate 1-(tert-Butoxycarbonyl)-4-(trifluoromethanesulfonyloxy)-3,6-dihydro-2H-pyridine 1-Boc-1,2,3,6-tetrahydropyridin-4- tert-butyl 4-(trifluoromethylsulfonyloxy)-3,6-dihydro-2H-pyridine-1-carboxylate 1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluo... 1-Boc-4-(trifluoromethylsulfonyloxy)-5,6-dihydro-2H-pyridine 138647-49-1 138647-49-4 C11H16F3NO5S